Pediatric glioblastoma target-specific efficient delivery of gemcitabine across the blood–brain barrier via carbon nitride dots

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7927-7938 ◽  
Author(s):  
Piumi Y. Liyanage ◽  
Yiqun Zhou ◽  
Abdulrahman O. Al-Youbi ◽  
Abdulaziz S. Bashammakh ◽  
Mohammad S. El-Shahawi ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Carbon Nitride ◽  
Drug Efficacy ◽  
Effective Drug ◽  
Brain Barrier ◽  
Drug Conjugation ◽  
Blood Brain ◽  
Efficient Delivery ◽  
Pediatric Glioblastoma ◽  
Selective Target

A carbon nitride dot nanocarrier system with effective drug conjugation and selective target delivering to achieve enhanced drug efficacy on pediatric glioblastomas, while proving capability to penetrate blood–brain barrier.

scholarly journals Blood–Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies

2017 ◽  
Vol 19 (6) ◽  
pp. 1600-1614 ◽  
Author(s):  
Loqman A. Mohamed ◽  
Shashirekha Markandaiah ◽  
Silvia Bonanno ◽  
Piera Pasinelli ◽  
Davide Trotti
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Blood Brain Barrier ◽  
Effective Drug ◽  
Brain Barrier ◽  
Blood Brain ◽  
Lateral Sclerosis

Solving the challenge of the blood–brain barrier to treat infections caused by Trypanosoma evansi: evaluation of nerolidol-loaded nanospheres in mice

Parasitology ◽  
2017 ◽  
Vol 144 (11) ◽  
pp. 1543-1550 ◽  
Author(s):  
MATHEUS D. BALDISSERA ◽  
CARINE F. SOUZA ◽  
ALINE A. BOLIGON ◽  
THIRSSA H. GRANDO ◽  
MARIÂNGELA F. DE SÁ ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Blood Brain Barrier ◽  
High Performance ◽  
Drug Efficacy ◽  
Trypanosoma Evansi ◽  
Brain Barrier ◽  
Active Principle ◽  
Diminazene Aceturate ◽  
Blood Brain ◽  
The Brain

SUMMARYDespite significant advances in therapies against Trypanosoma evansi, its effective elimination from the central nervous system (CNS) remains a difficult task. The incapacity of trypanocidal drugs to cross the blood–brain barrier (BBB) after systemic administrations makes the brain the main refuge area for T. evansi. Nanotechnology is showing great potential to improve drug efficacy, such as nerolidol-loaded nanospheres (N-NS). Thus, the aim of this study was to investigate whether the treatment with N-NS was able to cross the BBB and to eliminate T. evansi from the CNS. High-performance liquid chromatography revealed that N-NS can cross the BBB of T. evansi-infected mice, while free nerolidol (F-N) neither the trypanocidal drug diminazene aceturate (D.A.) were not detected in the brain tissue. Polymerase chain reaction revealed that 100% of the animals treated with N-NS were negatives for T. evansi in the brain tissue, while all infected animals treated with F-N or D.A. were positives. Thus, we concluded that nanotechnology improves the therapeutic efficacy of nerolidol, and enables the transport of its active principle through the BBB. In summary, N-NS treatment can eliminate the parasite from the CNS, and possesses potential to treat infected animals.

Grabody B, a Novel IGF-1 Receptor-Based Shuttle, Mediates Efficient Delivery of Biologics Across the Blood-Brain Barrier

2020 ◽  
Author(s):  
Jung-Won Shin ◽  
Sungwon An ◽  
Dongin Kim ◽  
Jinhyung Ahn ◽  
Jaehyun Eom ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Efficient Delivery

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood–Brain Barrier

2018 ◽  
Vol 29 (5) ◽  
pp. 1677-1689 ◽  
Author(s):  
Carlos Fernandes ◽  
Miguel Pinto ◽  
Cláudia Martins ◽  
Maria João Gomes ◽  
Bruno Sarmento ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Dietary Antioxidants ◽  
Blood Brain ◽  
Efficient Delivery

scholarly journals Disease-Induced Modulation of Drug Transporters at the Blood–Brain Barrier Level

2021 ◽  
Vol 22 (7) ◽  
pp. 3742
Author(s):  
Sweilem B. Al Rihani ◽  
Lucy I. Darakjian ◽  
Malavika Deodhar ◽  
Pamela Dow ◽  
Jacques Turgeon ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Drug Transporters ◽  
Neurovascular Unit ◽  
Drug Distribution ◽  
Drug Efficacy ◽  
Brain Barrier ◽  
Protective Function ◽  
Transporter Protein ◽  
Blood Brain ◽  
The Brain

The blood–brain barrier (BBB) is a highly selective and restrictive semipermeable network of cells and blood vessel constituents. All components of the neurovascular unit give to the BBB its crucial and protective function, i.e., to regulate homeostasis in the central nervous system (CNS) by removing substances from the endothelial compartment and supplying the brain with nutrients and other endogenous compounds. Many transporters have been identified that play a role in maintaining BBB integrity and homeostasis. As such, the restrictive nature of the BBB provides an obstacle for drug delivery to the CNS. Nevertheless, according to their physicochemical or pharmacological properties, drugs may reach the CNS by passive diffusion or be subjected to putative influx and/or efflux through BBB membrane transporters, allowing or limiting their distribution to the CNS. Drug transporters functionally expressed on various compartments of the BBB involve numerous proteins from either the ATP-binding cassette (ABC) or the solute carrier (SLC) superfamilies. Pathophysiological stressors, age, and age-associated disorders may alter the expression level and functionality of transporter protein elements that modulate drug distribution and accumulation into the brain, namely, drug efficacy and toxicity. This review focuses and sheds light on the influence of inflammatory conditions and diseases such as Alzheimer’s disease, epilepsy, and stroke on the expression and functionality of the BBB drug transporters, the consequential modulation of drug distribution to the brain, and their impact on drug efficacy and toxicity.

scholarly journals Ultrasound-sensitizing nanoparticle complex for overcoming the blood-brain barrier: an effective drug delivery system

2019 ◽  
Vol Volume 14 ◽  
pp. 3743-3752 ◽  
Author(s):  
Shin-Woo Ha ◽  
Kihwan Hwang ◽  
Jun Jin ◽  
Ae-Sin Cho ◽  
Tae Yoon Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Blood Brain Barrier ◽  
Delivery System ◽  
Effective Drug ◽  
Brain Barrier ◽  
Blood Brain ◽  
System P ◽  
Nanoparticle Complex

Mustard-inspired delivery shuttle for enhanced blood–brain barrier penetration and effective drug delivery in glioma therapy

2017 ◽  
Vol 5 (5) ◽  
pp. 1041-1050 ◽  
Author(s):  
Nan Wang ◽  
Pei Sun ◽  
Mingming Lv ◽  
Gangsheng Tong ◽  
Xin Jin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Effective Drug ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Penetration

A mustard-inspired delivery shuttle was constructed for enhanced blood–brain barrier penetration and effective drug delivery in glioma therapy.

Neuropsychological Disorders and their Nanocarriers

2020 ◽  
Vol 26 (19) ◽  
pp. 2247-2256 ◽  
Author(s):  
Surbhi Sharma ◽  
Shweta Dang
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Targeted Delivery ◽  
Antipsychotic Drugs ◽  
Effective Drug ◽  
Brain Barrier ◽  
Neuropsychological Disorders ◽  
Blood Brain ◽  
The People ◽  
The Brain

Neuropsychological disorders are now growing rapidly worldwide among the people of diverse backgrounds irrespective of age, gender, and geographical region. Such disorders not only disturb the normal life and functionality of an individual but also impact the social relationships of the patient and the people associated with them, and if not treated in time, it may also result in mortality in severe conditions. Various antipsychotic drugs have been developed but their use is often limited by issues related to effective drug delivery at the site of action i.e. brain, mainly because of the blood-brain barrier. To resolve these issues, researchers and scientists have been working to develop a more effective drug delivery system where drugs can cross the blood-brain barrier and reach the brain in more effective concentrations. Drugs have been modified and formulated into nano-carriers and experimental studies for efficient and targeted delivery of drugs have been conducted. This review focuses on certain common neuropsychological diseases and their nanocarriers developed for drug delivery in the brain and are discussed with a brief description of various experimental in vitro and in vivo studies. This review also focuses on the intranasal route for the delivery of antipsychotic drugs and constraints faced due to the blood-brain barrier by the drugs.

scholarly journals Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging

Small ◽  
2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Yu Cheng ◽  
Qing Dai ◽  
Ramin A. Morshed ◽  
Xiaobing Fan ◽  
Michelle L. Wegscheid ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Malignant Glioma ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Efficient Delivery ◽  
Delivery Platform
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