Graft copolymers with tunable amphiphilicity tailored for efficient dual drug delivery via encapsulation and pH-sensitive drug conjugation

2020 ◽  
Vol 11 (27) ◽  
pp. 4438-4453
Author(s):  
Markéta Bláhová ◽  
Eva Randárová ◽  
Rafal Konefał ◽  
Benjamin Nottelet ◽  
Tomáš Etrych
Keyword(s):  
Drug Delivery ◽  
Graft Copolymers ◽  
Ph Sensitive ◽  
Solution Properties ◽  
High Drug ◽  
Drug Conjugation ◽  
Hydroxypropyl Methacrylamide ◽  
Dual Drug

Amphiphilic poly(ε-caprolactone)-graft-(poly-N-(2-hydroxypropyl) methacrylamide) copolymers with tunable solution properties form stable micelles with high drug payload via simultaneous encapsulation and pH-sensitive covalent conjugation.

A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery

2017 ◽  
Vol 533 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Jie Hou ◽  
Chunlei Guo ◽  
Yuzhi Shi ◽  
Ergang Liu ◽  
Weibing Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
Hybrid Nanoparticle ◽  
High Drug Loading

pH sensitive surfactant-stabilized Fe3O4 magnetic nanocarriers for dual drug delivery

2018 ◽  
Vol 162 ◽  
pp. 163-171 ◽  
Author(s):  
Bijaideep Dutta ◽  
Neena G. Shetake ◽  
B.K. Barick ◽  
K.C. Barick ◽  
B.N. Pandey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Magnetic Nanocarriers ◽  
Dual Drug

Microfluidic conceived pH sensitive core–shell particles for dual drug delivery

2015 ◽  
Vol 478 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Ikram Ullah Khan ◽  
Lukas Stolch ◽  
Christophe A. Serra ◽  
Nicolas Anton ◽  
Roman Akasov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Core Shell ◽  
Shell Particles ◽  
Dual Drug

Dual drug delivery system based on pH-sensitive silk fibroin/alginate nanoparticles entrapped in PNIPAM hydrogel for treating severe infected burn wound

2020 ◽  
Vol 13 (1) ◽  
pp. 015005
Author(s):  
Fatemeh Rezaei ◽  
Sheyda Damoogh ◽  
Rui L Reis ◽  
Subhas C Kundu ◽  
Fatemeh Mottaghitalab ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Ph Sensitive ◽  
Burn Wound ◽  
Dual Drug

Combinatorial Drug Conjugation Enables Nanoparticle Dual-Drug Delivery

Small ◽  
2010 ◽  
Vol 6 (13) ◽  
pp. 1442-1448 ◽  
Author(s):  
Santosh Aryal ◽  
Che-Ming Jack Hu ◽  
Liangfang Zhang
Keyword(s):  
Drug Delivery ◽  
Drug Conjugation ◽  
Dual Drug

Association of Graft Copolymers of Alkyl Methacrylates with α-Methyl-ω-hydroxy-poly(oxyethylene) ethacrylates

1995 ◽  
Vol 60 (11) ◽  
pp. 1971-1985 ◽  
Author(s):  
Čestmír Koňák ◽  
Zdeněk Tuzar ◽  
Pavla Kopečková ◽  
Joseph D. Andrade ◽  
Jindřich Kopeček
Keyword(s):  
Light Scattering ◽  
Graft Copolymers ◽  
Water Solution ◽  
Pure Water ◽  
Solution Properties ◽  
Monomer Composition ◽  
Special Procedure ◽  
Methyl Cellosolve ◽  
Hexyl Methacrylate ◽  
Alkyl Methacrylates

Solution properties of the statistical copolymers of alkyl methacrylates (AMA) with α-methyl-ω-hydroxy-poly(oxyethylene) methacrylates (MPOEMA) (nonionic polysoaps) were studied using static and dynamic ligh scattering as a function of monomer composition and concentration in aqueous and methyl cellosolve solutions. The solubility of the copolymers in water was found to be dependent on molar contant of AMA. While copolymers with low content of hexyl methacrylate (HMA) (0 and 20 mole %) were directly soluble in water, forming true solutions with a low content of large swollen aggregates, copolymers with a higher content of HMA or lauryl methacrylate (LMA) were not directly dispersable in water. A special procedure, the stepwise dialysis from methyl cellosolve solutions against water, had to be used to prepare them in the pseudomicellar form. The copolymers were directly soluble in methyl cellosolve and its water solution containing up to 60 vol.% of water. Nevertheless, the light scattering experiments were dominated by light scattering of swollen particles of aggregated copolymer molecules. The copolymers were not soluble in the mixtures containing 70-100 vol.% of water. Paramaters of aggregates in the mixture with 60 vol.% of water and in pure water were found to be very similar.

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