scholarly journals Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease

2020 ◽  
Author(s):  
Charles Elias Assmann ◽  
Naiara Stefanello ◽  
Nathieli Bianchin Bottari ◽  
Jucimara Baldissarelli ◽  
Maria Rosa Chitolina Schetinger ◽  
...  
Keyword(s):  
Antioxidant System ◽  
Glutathione Antioxidant System ◽  
Immune Systems ◽  
Health And Disease

scholarly journals The Effect of Combination Therapy with Melatonin on the Enzymes of Glutathione System and the Level of Transforming Growth Factor- β1 in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease

2021 ◽  
Vol 11 (5) ◽  
pp. 359-369
Author(s):  
S. S. Popov ◽  
E. I. Anufrieva ◽  
E. D. Kryl’skii ◽  
A. N. Verevkin ◽  
K. K. Shulgin
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Growth Factor ◽  
Kidney Disease ◽  
Lipid Profile ◽  
Antioxidant System ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Glutathione Antioxidant System

Aim. The aim of the work was to assess the effect of combination therapy with melatonin on the clinical and biochemical parameters of chronic kidney disease (CKD) and type 2 diabetes mellitus (DM), the level of transforming growth factor-β1, lipid profile, activity of the glutathione antioxidant system enzymes and the activity of NADPH-generating enzymes in patients.Materials and methods. The study involved 60 people (19 men and 41 women, average age 65.6 ± 9.3 years) with chronic kidney disease associated with type 2 diabetes. The patients were divided into 2 groups. The first group of patients received basic treatment (n = 30, 8 men and 22 women, mean age 64.1 ± 7.9 years); the second group of participants (n = 30, 11 men and 19 women, mean age 69.0 ± 10.5 years) received 2 mg of melatonin in addition to the basic therapy. The control group consisted of 65 apparently healthy individuals (30 men and 35 women, average age 42.3±17.7 years) with normal indicators of general and biochemical blood tests. In the course of the work, the analysis of clinical and biochemical indicators and lipid profile in blood serum, the level of transforming growth factor-β1 by enzyme immunoassay, the activity of enzymes of the glutathione antioxidant system and NADPH-generating enzymes by the spectrophotometric method were carried out.Results. The use of melatonin additionally with basic treatment compared with standard therapy led to a decrease in proteinuria (p=0.010), hyperglycemia (p=0.019), urea concentration (p=0.043), glycated hemoglobin (p=0.045) and transforming growth factor-β1 levels (p=0.020) in patients with CKD. In addition, the use of this drug led to a changing of the lipid profile, and the activity of glutathione antioxidant system enzymes and NADPH-generating enzymes.Conclusion. The differences observed during the study were apparently caused by the action of melatonin, which has nephroprotective and hypoglycemic properties, the ability to neutralize reactive oxygen species and activate the antioxidant system functioning. 

Control of Oxidative Reactions of Hemoglobin in the Design of Blood Substitutes: Role of the Ascorbate-Glutathione Antioxidant System

2009 ◽  
Vol 33 (2) ◽  
pp. 115-126 ◽  
Author(s):  
Jan Simoni ◽  
Javier Villanueva-Meyer ◽  
Grace Simoni ◽  
John F. Moeller ◽  
Donald E. Wesson
Keyword(s):  
Antioxidant System ◽  
Blood Substitutes ◽  
Glutathione Antioxidant System ◽  
Oxidative Reactions

scholarly journals Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain

2008 ◽  
Vol 227 (1) ◽  
pp. 147-154 ◽  
Author(s):  
James Stringari ◽  
Adriana K.C. Nunes ◽  
Jeferson L. Franco ◽  
Denise Bohrer ◽  
Solange C. Garcia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Antioxidant System ◽  
Glutathione Antioxidant System ◽  
Methylmercury Exposure

scholarly journals Activity of glutathione-dependent enzymes in spermatozoa in patients with pathospermia

2017 ◽  
Author(s):  
O. K. Onufrovych ◽  
R. V. Fafula ◽  
Io. A. Nakonechnyi ◽  
D. Z. Vorobets ◽  
U. P. Iefremova ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Glutathione Reductase ◽  
Antioxidant System ◽  
Reductase Activity ◽  
Sperm Cells ◽  
Compensatory Mechanisms ◽  
Glutathione Antioxidant System ◽  
Healthy Men ◽  
Infertile Men ◽  
Glutathione Reductase Activity

The results of glutathione peroxidase and glutathione reductase activity in spermatozoa of patients with different forms pathospermia are presented in the paper. It was shown that glutathione peroxidase and glutathione reductase activity in sperm cells of patients is reduced in comparison with healthy men with preserved fertility. However, the most expressed changes in the activity of glutathione peroxidase and glutathione reductase are in spermatozoa of infertile men with associated forms patospermia and leucospermia. These changes indicate exhaustion of compensatory mechanisms of glutathione antioxidant system in the sperm cells of infertile men with pahospermia.

The Functional Significance of Endocrine-immune Interactions in Health and Disease

2020 ◽  
Vol 21 (1) ◽  
pp. 52-65
Author(s):  
Sridhar Muthusami ◽  
Balasubramanian Vidya ◽  
Esaki M Shankar ◽  
Jamuna Vadivelu ◽  
Ilangovan Ramachandran ◽  
...  
Keyword(s):  
Immune System ◽  
Cell Differentiation ◽  
Amino Acid ◽  
Functional Role ◽  
Immune Cell ◽  
Amino Acid Derivatives ◽  
Endocrine Glands ◽  
Immune Systems ◽  
Health And Disease

Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids and inflammation is widely known. However, the role of peptide hormones and amino acid derivatives such as growth and thyroid hormones, prolactin, dopamine, and thymopoietin in regulating the functioning of the immune system remains unclear. Here, we reviewed the findings pertinent to the functional role of hormone-immune interactions in health and disease and proposed perspective directions for translational research in the field.

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