ACTIVATION OF ENDOGENOUS INTOXICATION UNDER THE INFLUENCE OF ANESTHETICS IN EXPERIMENTAL HYPERTHYROIDISM

The aim: To determine the features of endogenous intoxication in the blood of experimental animals in the setting of simulated hyperthyroidism under the influence of various anesthetics. Materials and methods: Rats were injected L-thyroxine to simulate hyperthyroidism, and sodium thiopental and dexmedetomidine in the setting of euthyroidism and hyperthyroidism. Results: An increase in the activity of endogenous intoxication, the content of medium-molecular peptides (MMW1, MMW2) and their coefficient (K = MSM2 / MSM1) were observed in the erythrocytes of experimental animals with hyperthyroidism. A significant difference in the rates of endogenous intoxication with the use of sodium thiopental and dexmedetomidine hydrochloride in the setting of euthyroidism and hyperthyroidism has been determined. Conclusions: In experimental hyperthyroidism in rats, an increase in the level of endogenous intoxication has been determined, which is indicated by an increase in the permeability of erythrocyte membranes and an increase in the level of macromolecular fractions of medium-weight molecules in the blood.The use of sodium thiopental and dexmedetomidine in the setting of euthyroidism and hyperthyroidism is accompanied by pronounced changes in the body of experimental animals, namely: increased endogenous intoxication, which deepens the destructive changes in the organs and systems of experimental animals.