scholarly journals Disturbances of function of the glutathione antioxidant system in gastric mucosa, liver and erythrocytes of rats with experimental gastric lesions

2015 ◽  
Vol 2015 (1) ◽  
pp. 26-31 ◽  
Author(s):  
O. KHAVRONA ◽  
Keyword(s):  
Gastric Mucosa ◽  
Antioxidant System ◽  
Gastric Lesions ◽  
Glutathione Antioxidant System

scholarly journals The Effect of Combination Therapy with Melatonin on the Enzymes of Glutathione System and the Level of Transforming Growth Factor- β1 in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease

2021 ◽  
Vol 11 (5) ◽  
pp. 359-369
Author(s):  
S. S. Popov ◽  
E. I. Anufrieva ◽  
E. D. Kryl’skii ◽  
A. N. Verevkin ◽  
K. K. Shulgin
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Growth Factor ◽  
Kidney Disease ◽  
Lipid Profile ◽  
Antioxidant System ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Glutathione Antioxidant System

Aim. The aim of the work was to assess the effect of combination therapy with melatonin on the clinical and biochemical parameters of chronic kidney disease (CKD) and type 2 diabetes mellitus (DM), the level of transforming growth factor-β1, lipid profile, activity of the glutathione antioxidant system enzymes and the activity of NADPH-generating enzymes in patients.Materials and methods. The study involved 60 people (19 men and 41 women, average age 65.6 ± 9.3 years) with chronic kidney disease associated with type 2 diabetes. The patients were divided into 2 groups. The first group of patients received basic treatment (n = 30, 8 men and 22 women, mean age 64.1 ± 7.9 years); the second group of participants (n = 30, 11 men and 19 women, mean age 69.0 ± 10.5 years) received 2 mg of melatonin in addition to the basic therapy. The control group consisted of 65 apparently healthy individuals (30 men and 35 women, average age 42.3±17.7 years) with normal indicators of general and biochemical blood tests. In the course of the work, the analysis of clinical and biochemical indicators and lipid profile in blood serum, the level of transforming growth factor-β1 by enzyme immunoassay, the activity of enzymes of the glutathione antioxidant system and NADPH-generating enzymes by the spectrophotometric method were carried out.Results. The use of melatonin additionally with basic treatment compared with standard therapy led to a decrease in proteinuria (p=0.010), hyperglycemia (p=0.019), urea concentration (p=0.043), glycated hemoglobin (p=0.045) and transforming growth factor-β1 levels (p=0.020) in patients with CKD. In addition, the use of this drug led to a changing of the lipid profile, and the activity of glutathione antioxidant system enzymes and NADPH-generating enzymes.Conclusion. The differences observed during the study were apparently caused by the action of melatonin, which has nephroprotective and hypoglycemic properties, the ability to neutralize reactive oxygen species and activate the antioxidant system functioning. 

scholarly journals Gastroprotective Activity of Epitaondiol and Sargaol

2011 ◽  
Vol 6 (8) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Carlos Areche ◽  
Aurelio San-Martín ◽  
Juana Rovinosa ◽  
Beatriz Sepúlveda
Keyword(s):  
Gastric Mucosa ◽  
Brown Alga ◽  
Gastric Lesions ◽  
Gastroprotective Activity

The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice.

scholarly journals THE COMPARISON OF THE EFFECT BETWEEN ALGINATE-BASED RAFT-FORMING LIQUID AND ALGINATE LIQUID ON GASTROESOPHAGEAL REFLUX DISEASE AND GASTRIC ULCER IN RATS

2017 ◽  
Vol 10 (12) ◽  
pp. 105
Author(s):  
Hakim Bangun ◽  
Anayanti Arianto ◽  
Ririn Astya ◽  
Gontar A Siregar
Keyword(s):  
Gastric Ulcer ◽  
Gastroesophageal Reflux Disease ◽  
Gastric Mucosa ◽  
Gastroesophageal Reflux ◽  
Negative Control ◽  
Gastric Lesions ◽  
Esophageal Erosion ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective: The objective of the study was to compare the effect between alginate (Alg)-based raft-forming and Alg liquid on healing gastroesophageal reflux disease (GERD) and gastric ulcer in rats.Methods: Each of the 18 fasted rats was given 1 ml acidified pepsin. Then, rats were divided into three groups. Each group consisted of six rats. Group 1 (negative control) was orally given 1 ml distilled water, Group 2 was given 1 ml Alg-based raft-forming liquid, and Group 3 was given 1 ml Alg liquid. Then, the abdomen of rats was incised under anesthesia with ketamine, and then both their pylorus and the forestomach were ligated to form gastric reflux. After 4 hrs, all rats were killed with chloroform and their esophagus and stomach were examined macroscopically and microscopically (histopathology).Results: On macroscopic observation, all of the Group 1 rats (negative control) showed esophageal lesions and gastric lesions. Four rats of Group 2 (given Alg-based raft-forming) showed no esophageal lesion and two more rats showed a slight lesion, but all of the tested rats showed gastric lesions. All of the rats of the Group 3 (given Alg liquid) showed esophageal lesions, but no gastric lesion on four rats and slight lesion on two rats. Microscopic observations showed that all of the Group 1 rats (negative control) showed esophageal erosion and gastric mucosa lesions. Rats of the Group 2 (given Alg-based raft-forming) showed almost no esophageal erosion, but all of them showed erosion of gastric mucosa. Rats of the Group 3 (given Alg liquid) showed esophageal erosion in all tested rats, but almost no gastric mucosa lesion.Conclusion: Alg-base raft-forming liquid is more effective in healing of GERD than Alg liquid. However, Alg-liquid is more effective in healing of gastric ulcer than Alg-based raft-forming liquid.

Control of Oxidative Reactions of Hemoglobin in the Design of Blood Substitutes: Role of the Ascorbate-Glutathione Antioxidant System

2009 ◽  
Vol 33 (2) ◽  
pp. 115-126 ◽  
Author(s):  
Jan Simoni ◽  
Javier Villanueva-Meyer ◽  
Grace Simoni ◽  
John F. Moeller ◽  
Donald E. Wesson
Keyword(s):  
Antioxidant System ◽  
Blood Substitutes ◽  
Glutathione Antioxidant System ◽  
Oxidative Reactions

scholarly journals Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain

2008 ◽  
Vol 227 (1) ◽  
pp. 147-154 ◽  
Author(s):  
James Stringari ◽  
Adriana K.C. Nunes ◽  
Jeferson L. Franco ◽  
Denise Bohrer ◽  
Solange C. Garcia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Antioxidant System ◽  
Glutathione Antioxidant System ◽  
Methylmercury Exposure

scholarly journals THE OCCURRENCE OF GASTRIC LESIONS IN SLAUGHTERED PIGS AT THE KUMASI ABATTOIR, GHANA

2016 ◽  
Vol 14 (1) ◽  
pp. 85-91 ◽  
Author(s):  
M. A. Laryea ◽  
B. O. Emikpe ◽  
V. Attoh-Kotoku ◽  
O. O. Omotosho ◽  
D. A. Asare ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Mucosa ◽  
Preliminary Investigation ◽  
Content Volume ◽  
Stomach Contents ◽  
Standard Technique ◽  
Glandular Stomach ◽  
Gastric Lesions ◽  
Chi Square ◽  
On Farm

Information on the occurrence of gastric lesions in pigs in Ghana is lacking in literature. This study was designed as a preliminary investigation to determine the occurrence and pattern of gastric lesion in pigs in Ghana. Ante-mortem animal assessment and post-slaughter stomach evaluation were conducted on 75 pigs out of a total of 694 slaughtered between October, 2014 and March, 2015 at the Kumasi abattoir. The gross lesions observed on the gastric mucosa were graded using standard technique. Stomach contents were assessed and tissue sections were used for histopathology evaluation. The data obtained were cross tabulated and analyzed using Chi-square and One-way ANOVA. Significance was determined at p < 0.05.The prevalence of gastric lesions in the sampled population was 25.3% while the non-glandular stomach (pars oesophagea) and glandular had a prevalence of 17.3% and 21.3% respectively. The predominant lesions observed were epithelial changes in the pars oesophagea and ulcers in glandular region of the stomach. Epithelial changes were restricted to the non-glandular region and it affected 8 (42.1%) of the stomachs with lesions. Erosions and ulceration were observed in the pars oesophagea and glandular stomach while mucosa damage was restricted to the glandular stomach. Lesions were observed in the two breeds studied and the stomach contents of the pigs were mostly finely grounded compounded feed, millet/maize chaff or cassava based feed. Histopathological evaluation of gastric mucosa tissues revealed erosion, multifocal ulcerations with occasional presence of silver staining micro-organisms. There was no significant association between breed, age, sex and occurrence of gastric lesions in pigs. Stomach content volume and feed type were identified as risk factors. Evidence of stomach infection with spirochetes was also observed. Our findings reveal the occurrence of gastric lesions in pigs in Ghana and its associated risk factors. It is therefore recommended that stake-holders should adopt on-farm and abattoir periodic monitoring of the condition as well as improved animal welfare and hygiene practices both on farm and in transit.

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