scholarly journals An Overview of Chitosan-Xanthan Gum Matrices as Controlled Release Drug Carriers

2018 ◽  
Author(s):  
Suha M. Dadou ◽  
Milan D. Antonijevic ◽  
Babur Z. Chowdhry ◽  
Adnan A. Badwan
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
Drug Carriers ◽  
Release Drug

scholarly journals Preparation and Sustained-Release Performance of PLGA Microcapsule Carrier System

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1758
Author(s):  
Shuaikai Ren ◽  
Chunxin Wang ◽  
Liang Guo ◽  
Congcong Xu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Encapsulation Efficiency ◽  
Drug Carriers ◽  
Optimum Conditions ◽  
Carrier System ◽  
Preparation Conditions ◽  
Encapsulation Rate ◽  
Release Drug ◽  
Release Curve

Microcapsules have been widely studied owing to their biocompatibility and potential for application in various areas, particularly drug delivery. However, the size of microcapsules is difficult to control, and the size distribution is very broad via various encapsulation techniques. Therefore, it is necessary to obtain microcapsules with uniform and tailored size for the construction of controlled-release drug carriers. In this study, emulsification and solvent evaporation methods were used to prepare a variety of ovalbumin-loaded poly (lactic-co-glycolic acid) (PLGA) microcapsules to determine the optimal preparation conditions. The particle size of the PLGA microcapsules prepared using the optimum conditions was approximately 200 nm, which showed good dispersibility with an ovalbumin encapsulation rate of more than 60%. In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase. The release curve showed that the rate of protein release from the microcapsules could be controlled by adjusting the pore size. These findings demonstrated that we could tailor the morphology and structure of microcapsules by regulating the preparation conditions, thus controlling the encapsulation efficiency and the release performance of the microcapsule carrier system. We envision that this controlled-release novel microcapsule carrier system shows great potential for biomedical applications.

Controlled-release drug carriers based mesoporous silica spheres with hierarchical hollow/nano structure

2016 ◽  
Vol 24 (1) ◽  
pp. 241-248 ◽  
Author(s):  
Yifei Teng ◽  
Yanqiu Jiang ◽  
Yining Zhang ◽  
Xianzhu Xu ◽  
Kaifeng Lin
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Drug Carriers ◽  
Silica Spheres ◽  
Nano Structure ◽  
Release Drug ◽  
Mesoporous Silica Spheres

Nano-cellulose 3D-networks as controlled-release drug carriers

2013 ◽  
Vol 1 (23) ◽  
pp. 2976 ◽  
Author(s):  
Lin Huang ◽  
Xiuli Chen ◽  
Thanh Xuan Nguyen ◽  
Huiru Tang ◽  
Liming Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carriers ◽  
Release Drug ◽  
Nano Cellulose ◽  
3D Networks

Controlled-release drug carriers based hierarchical silica microtubes templated from cellulose acetate nanofibers

2015 ◽  
Vol 132 (38) ◽  
pp. n/a-n/a ◽  
Author(s):  
Chengying Jia ◽  
Junlong Song ◽  
Yongcan Jin ◽  
Orlando J. Rojas
Keyword(s):  
Controlled Release ◽  
Cellulose Acetate ◽  
Drug Carriers ◽  
Release Drug

scholarly journals Thermosensitive star polymer pompons with a core–arm structure as thermo-responsive controlled release drug carriers

RSC Advances ◽  
2018 ◽  
Vol 8 (28) ◽  
pp. 15604-15612 ◽  
Author(s):  
Na Xu ◽  
Xiaobei Huang ◽  
Guangfu Yin ◽  
Meijiao Bu ◽  
Ximing Pu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Star Polymer ◽  
Release Drug

Herein, a thermosensitive star polymer pompon with a core–arm structure was synthesized using a grafting-on method as a thermo-responsive controlled release drug carrier.

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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