Crowning, rotating, and emanating hierophanies with elevatio aspect in wayside shrines

My aim in this paper is to investigate the variants of directionality implied in visual hieratic texts as religious markers in the sacrosphere, which are substantially expressed in the form of a wayside shrine/cross. The methodological underpinnings for this project rely on the proposed semiotactics (cf. Haładewicz-Grzelak, Małgorzata. 2012. Dynamic modeling of visual texts: A relational model. Semiotica 190(1/4). 211–251): the investigative perspective modeled after phonotactics – a branch of phonology investigating the restrictions on and the possibilities of phoneme combinations in languages (cf. Dziubalska-Kołaczyk, Katarzyna & Daria Zielińska. 2011. Universal phonotactic and morphonotactic preferences in second language acquisition. In Katarzyna Dziubalska-Kołaczyk, Magdalena Wrembel & Małgorzata Kul (eds.), Achievements and perspectives in SLA of speech: New sounds 2010, 53–64. Frankfurt am Main: Peter Lang). The study draws on digital documentation of wayside shrines, crosses, and sacrality markers on houses collected by the author in various European countries (2009–2021), focusing in particular on the material collected in the area of present Slovakia, Ukraine, Austria, Slovenia, and the region of the Beskid Mountains in Poland. It shows how bodily hexis is inscribed into the phenomenology of a wayside shrine through particular types of hierophanic dynamics. The study also focuses on the aspect of headedness and markedness in the nano-structure of a sign, surfacing as directionality in the conceptualization of the religious sphere by particular communities.

Photodetectors Based on Micro-nano Structure Material

Photodetectors converting optical signals into electrical signals have been widely utilized and have received more and more attention in scientific research and industrial fields including optical interconnection, optical communication, and environmental monitoring. Herein, we summarize the latest development of photodetectors with different micro-nano structures and different materials and the performance indicators of photodetectors. Several photodetectors, such as flexible, ultraviolet two-dimensional (2D) microscale, and dual-band photodetectors, are listed in this minireview. Meanwhile, the current bottleneck and future development prospects of the photodetector are discussed.

Advances in Laser Drilling of Structural Ceramics

The high-quality, high-efficiency micro-hole drilling of structural ceramics to improve the thermal conductivity of hot-end parts or achieve high-density electronic packaging is still a technical challenge for conventional processing techniques. Recently, the laser drilling method (LDM) has become the preferred processing tool for structural ceramics, and it plays an irreplaceable role in the industrialized processing of group holes on structural ceramic surfaces. A variety of LDMs such as long pulsed laser drilling, short pulsed laser drilling, ultrafast pulsed laser drilling, liquid-assisted laser drilling, combined pulse laser drilling have been developed to achieved high-quality and high-efficiency micro-hole drilling through controlling the laser–matter interaction. This article reviews the characteristics of different LDMs and systematically compares the morphology, diameter, circularity, taper angle, cross-section, heat affect zone, recast layer, cracks, roughness, micro–nano structure, photothermal effect and photochemical reaction of the drilling. Additionally, exactly what processing parameters and ambient environments are optimal for precise and efficient laser drilling and their recent advancements were analyzed. Finally, a summary and outlook of the LDM technology are also highlighted.

A Polyhydroxyalkanoates-Based Carrier Platform of Bioactive Substances for Therapeutic Applications

Bioactive substances (BAS), such as small molecule drugs, proteins, RNA, cells, etc., play a vital role in many therapeutic applications, especially in tissue repair and regeneration. However, the therapeutic effect is still a challenge due to the uncontrollable release and instable physico-chemical properties of bioactive components. To address this, many biodegradable carrier systems of micro-nano structures have been rapidly developed based on different biocompatible polymers including polyhydroxyalkanoates (PHA), the microbial synthesized polyesters, to provide load protection and controlled-release of BAS. We herein highlight the developments of PHA-based carrier systems in recent therapeutic studies, and give an overview of its prospective applications in various disease treatments. Specifically, the biosynthesis and material properties of diverse PHA polymers, designs and fabrication of micro- and nano-structure PHA particles, as well as therapeutic studies based on PHA particles, are summarized to give a comprehensive landscape of PHA-based BAS carriers and applications thereof. Moreover, recent efforts focusing on novel-type BAS nano-carriers, the functionalized self-assembled PHA granules in vivo, was discussed in this review, proposing the underlying innovations of designs and fabrications of PHA-based BAS carriers powered by synthetic biology. This review outlines a promising and applicable BAS carrier platform of novelty based on PHA particles for different medical uses.

Hierarchical Hydrogels with Ordered Micro-Nano Structures for Cancer-on-a-Chip Construction

In the drug therapy of tumor, efficient and stable drug screening platforms are required since the drug efficacy varies individually. Here, inspired by the microstructures of hepatic lobules, in which hepatocytes obtain nutrients from both capillary vessel and the central vein, we present a novel hierarchical hydrogel system with ordered micro-nano structure for liver cancer-on-a-chip construction and drug screening. The hierarchical hydrogel system was fabricated by using pregel to fill and replicate self-assembled colloidal crystal arrays and microcolumn array template. Due to the synergistic effect of its interconnected micro-nano structures, the resultant system could not only precisely control the size of cell spheroids but also realize adequate nutrient supply of cell spheroids. We have demonstrated that by integrating the hierarchical hydrogel system into a multichannel concentration gradients microfluidic chip, a functional liver cancer-on-a-chip could be constructed for high-throughput drug screening with good repeatability and high accuracy. These results indicated that the hierarchical hydrogel system and its derived liver cancer-on-a-chip are ideal platforms for drug screening and have great application potential in the field of personalized medicine.

Improving the Specific Surface Area of Etched Aluminum Foil by Fabricating the Micro/Nano Structure

Aluminum foil with micro/nano structure has been prepared by electrochemical DC etching and a subsequent anodization treatment followed by removal of the alumina film. When the micron-sized tunnels were generated on the etched aluminum foil, the size and distribution of the nano-concave formed on the sidewall of the etched tunnels varied with the anodized time in H2SO4 and C4H6O6 electrolyte. The optimal value of the specific surface area for the aluminum foil with micro/nano structure is approximately four times larger than that of the only etched aluminum foil. It is indicated from the chronoamperometry and BET measurements that the specific capacitance of aluminum foil with micro/nano structure can be significantly improved by suitable anodization in H2SO4 electrolyte, in comparison with a comparatively small increasement in C4H6O6 electrolyte. This can be attributed to the fact that the tardy anodization process will consume a considerable amount of aluminum substrate, resulting in the aggravation of the merged tunnels.