scholarly journals Thermosensitive star polymer pompons with a core–arm structure as thermo-responsive controlled release drug carriers

RSC Advances ◽  
2018 ◽  
Vol 8 (28) ◽  
pp. 15604-15612 ◽  
Author(s):  
Na Xu ◽  
Xiaobei Huang ◽  
Guangfu Yin ◽  
Meijiao Bu ◽  
Ximing Pu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Star Polymer ◽  
Release Drug

Herein, a thermosensitive star polymer pompon with a core–arm structure was synthesized using a grafting-on method as a thermo-responsive controlled release drug carrier.

scholarly journals Preparation and Sustained-Release Performance of PLGA Microcapsule Carrier System

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1758
Author(s):  
Shuaikai Ren ◽  
Chunxin Wang ◽  
Liang Guo ◽  
Congcong Xu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Encapsulation Efficiency ◽  
Drug Carriers ◽  
Optimum Conditions ◽  
Carrier System ◽  
Preparation Conditions ◽  
Encapsulation Rate ◽  
Release Drug ◽  
Release Curve

Microcapsules have been widely studied owing to their biocompatibility and potential for application in various areas, particularly drug delivery. However, the size of microcapsules is difficult to control, and the size distribution is very broad via various encapsulation techniques. Therefore, it is necessary to obtain microcapsules with uniform and tailored size for the construction of controlled-release drug carriers. In this study, emulsification and solvent evaporation methods were used to prepare a variety of ovalbumin-loaded poly (lactic-co-glycolic acid) (PLGA) microcapsules to determine the optimal preparation conditions. The particle size of the PLGA microcapsules prepared using the optimum conditions was approximately 200 nm, which showed good dispersibility with an ovalbumin encapsulation rate of more than 60%. In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase. The release curve showed that the rate of protein release from the microcapsules could be controlled by adjusting the pore size. These findings demonstrated that we could tailor the morphology and structure of microcapsules by regulating the preparation conditions, thus controlling the encapsulation efficiency and the release performance of the microcapsule carrier system. We envision that this controlled-release novel microcapsule carrier system shows great potential for biomedical applications.

Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

2020 ◽  
Vol 35 (3) ◽  
pp. 658-664
Author(s):  
Shouxia Wang ◽  
Zhiyi Hu ◽  
Jie Hu ◽  
Zhiming Qiu ◽  
Junli Li ◽  
...  
Keyword(s):  
Controlled Release ◽  
Shell Structure ◽  
Drug Carrier ◽  
Core Shell ◽  
The Core ◽  
Release Drug ◽  
Core Shell Structure

Controlled-release drug carriers based mesoporous silica spheres with hierarchical hollow/nano structure

2016 ◽  
Vol 24 (1) ◽  
pp. 241-248 ◽  
Author(s):  
Yifei Teng ◽  
Yanqiu Jiang ◽  
Yining Zhang ◽  
Xianzhu Xu ◽  
Kaifeng Lin
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Drug Carriers ◽  
Silica Spheres ◽  
Nano Structure ◽  
Release Drug ◽  
Mesoporous Silica Spheres

Nano-cellulose 3D-networks as controlled-release drug carriers

2013 ◽  
Vol 1 (23) ◽  
pp. 2976 ◽  
Author(s):  
Lin Huang ◽  
Xiuli Chen ◽  
Thanh Xuan Nguyen ◽  
Huiru Tang ◽  
Liming Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carriers ◽  
Release Drug ◽  
Nano Cellulose ◽  
3D Networks

scholarly journals Formulation and Evaluation of Controlled Release Maintenance Dose Loaded Niosomes of Anti-Hypertensive Drug

2019 ◽  
Vol 11 (06) ◽  
Author(s):  
Chandani Makvana ◽  
Satyajit Sahoo
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Zeta Potential ◽  
Drug Carrier ◽  
Entrapment Efficiency ◽  
Drug Carriers ◽  
Vesicle Size ◽  
Drug Content ◽  
Span 60

The present study was aimed to formulate, comparatively evaluate and optimize multiple lipid drug carriers of valsartan for oral controlled release to overcome the problems associated with the drug such as bioavailability, to reduce the dosage regimen, half life and to determine the appropriateness of niosomal formulation as a drug carrier. Ether injection method was chosen for the formulation of physically and chemically stable niosomes of valsartan. The formulation and process parameters were optimized by manufacturing placebo niosomes. Than drug loaded niosome was prepared by varying the concentration of span 60. The prepared nine formulations were evaluated for various parameters. Placebo niosomes were evaluated for appearance, odour, texture, creaming volume, pH and changes after 15 days. The medicated nine formulations were evaluated for organoleptic properties (appearance/color, odour), pH, total drug content, entrapment efficiency, mean particle size and polydispersibility index, zeta potential and In-vitro drug release. All formulations were off-white in color, odourless, and fluid in nature. It was stable and did not show sedimentation. The pH was found to be in the range of 4.6-5.4. Drug content was found in the range of 89.13 to 99.52. The Entrapment efficiency was found in range of 79.05 to 98.24. The mean vesicle size of drug loaded niosomes of the different batches ranged between 2.52-3.42μm. The polydispersvity index was in the range of 0.325 to 0.420 which indicates a narrow vesicle size distribution. The values of zeta potential were in the range of -20.29 mV to -30.55 mV which indicates that niosome had sufficient charge and mobility to inhibit aggregation of vesicles. All the nine formulations shows constant drug release in controlled manner up to 24 h. Formulation V7 was considered to be the best formulation as the % drug content (99.52 ± 0.97), % entrapment efficiency (98.24 ± 1.50) and % drug release at the end of 24th h (98.55) were high for V7. The optimized formulation V7 showed higher degree of correlation coefficient (r2) 0.9805 which indicates process of constant drug release from dosage form. The present study concludes that the prepared niosome is a convenient and efficiency carrier for the delivery of antihypertensive drug. Besides this, it provided controlled delivery of drug.

Improved pH-Controlled Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide

2021 ◽  
Author(s):  
Abdelnour Alhourani ◽  
Jan-Lukas Førde ◽  
Lutz Eichacker ◽  
Lars Herfindal ◽  
Hanne Hagland
Keyword(s):  
Graphene Oxide ◽  
Controlled Release ◽  
Graphene Nanosheets ◽  
Drug Carrier ◽  
Chemical Vapor ◽  
Drug Carriers ◽  
Covalent Attachment ◽  
Cancer Drug ◽  
Delivery Options ◽  
Ph Controlled

Graphene-based drug carriers provide a promising addition to current cancer drug 8 delivery options. Increased accessibility of high-quality graphene made by plasma- enhanced chemical vapor deposition (PE-CVD) makes it an attractive material to re-visit in comparison to the widely studied graphene oxide (GO) in drug delivery. Here we show the potential of re-purposing the metabolic drug phenformin for cancer treatment in terms of stability, binding, and pH-controlled release. Using covalent attachment of polyethylene glycol (PEG) onto pristine (PE-CVD) graphene, we show that the PEG stabilized graphene nanosheets (PGNS) drug carrier is stable in aqueous solutions, exhibit a higher binding affinity towards phenformin than conventional GO. Moreover, we experimentally demonstrate an improved drug release in PGNS than GO in pH levels lower than physiological conditions comparable to an acidic tumor microenvironment.

Controlled-release drug carriers based hierarchical silica microtubes templated from cellulose acetate nanofibers

2015 ◽  
Vol 132 (38) ◽  
pp. n/a-n/a ◽  
Author(s):  
Chengying Jia ◽  
Junlong Song ◽  
Yongcan Jin ◽  
Orlando J. Rojas
Keyword(s):  
Controlled Release ◽  
Cellulose Acetate ◽  
Drug Carriers ◽  
Release Drug

Recent Advances in Nanocapsule: Types, Preparation Methods and Characterizatio

2019 ◽  
Vol 12 (4) ◽  
pp. 4573-4579
Author(s):  
Raja Sekharan Thenrajan
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Pharmacokinetic Profile ◽  
Polymeric Membrane ◽  
Solid Core ◽  
Preparation Methods ◽  
Other Substances ◽  
Colloidal Drug Carrier

Nanocapsules are submicroscopic colloidal drug carrier systems consist of a liquid/solid core in which the drug, gene, protein, and other substances are incorporated into the interior cavity that is surrounded by a distinctive polymeric membrane. Polymers like collagen, albumin, and gelatin are mainly using polymers in nanocapsule formulations. Nanocapsules can serve as nano-sized drug carriers to achieve controlled release as well as efficient drug targeting. The process is used to improve the poor aqueous drug solubility, taste, stabilizing drugs by protecting the molecule from the environment, providing the desired pharmacokinetic profile, allowing controlled release, as well as facilitating oral administration. Capsules are generally prepared between the range of 100 and 1000 nm. Their release and degradation properties largely depend on the composition and the structure of the capsule walls. The dispersion stability of nanocapsules determined by the surfactant, nature of the outer coating. This review describes various facts of nanocapsule drug delivery systems in relation to the method of formulation, characterization, potential benefits and risks, and pharmaceutical applications in drug delivery.

Composite of Functional Mesoporous Silica and DNA: An Enzyme-Responsive Controlled Release Drug Carrier System

2014 ◽  
Vol 6 (11) ◽  
pp. 8042-8047 ◽  
Author(s):  
Guilong Zhang ◽  
Minglei Yang ◽  
Dongqing Cai ◽  
Kang Zheng ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Drug Carrier ◽  
Carrier System ◽  
Release Drug ◽  
Drug Carrier System
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