scholarly journals Effects of hot-water extract of <i>Paecilomyces hepiali</i> on hypertension parameters in Spontaneously Hypertensive Rats

2014 ◽  
Vol 04 (08) ◽  
pp. 436-443 ◽  
Author(s):  
Alfred Chioza ◽  
Shoji Ohga
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Water Extract ◽  
Hot Water ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Hot Water Extract ◽  
Paecilomyces Hepiali

Standardized ethanol-water extract of Ficus deltoidea Angustifolia reduces blood pressure in spontaneously hypertensive rats

2019 ◽  
Vol 41 (5) ◽  
pp. 444-451
Author(s):  
Mohd Saleh Ahmad Kamal ◽  
Nor Hadiani Ismail ◽  
Nuraliza Abdul Satar ◽  
Norasikin Abdul Azis ◽  
Zurain Radjeni ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Water Extract ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Ficus Deltoidea

Effects of Gegen (Puerariae lobatae Radix) water extract on improving detrusor overactivity in spontaneously hypertensive rats

Phytomedicine ◽  
2016 ◽  
Vol 23 (6) ◽  
pp. 672-678 ◽  
Author(s):  
Xuelin Zhou ◽  
Wai Ping Lam ◽  
Hong Chai Tang ◽  
Chi-Man Koon ◽  
Ling Cheng ◽  
...  
Keyword(s):  
Detrusor Overactivity ◽  
Spontaneously Hypertensive Rats ◽  
Water Extract ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Effect of Angelica acutiloba Extract on Blood flow Regulation in Stroke-prone Spontaneously Hypertensive Rats

2016 ◽  
Vol 11 (10) ◽  
pp. 1934578X1601101
Author(s):  
Hiroko Negishi ◽  
Sari Sugahama ◽  
Ayaka Kawakami ◽  
Junna Kondo ◽  
Yuriko Nishigaki ◽  
...  
Keyword(s):  
Blood Flow ◽  
Spontaneously Hypertensive Rats ◽  
Water Extract ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Flow Response ◽  
Angelica Acutiloba

Angelica acutiloba Kitagawa (Yamato Toki) is a herbal medicine known to exhibit various health effects. In this study, we used a rat model to examine the effects of two different Yamato Toki extracts on the blood flow response of the instep of the hind paw. Twelve-week- old male stroke-prone spontaneously hypertensive rats (SHRSP) were orally given 200 mg of a water extract of Yamato Toki (n=6), 200 mg of an ethanol extract of Yamato Toki (n = 6), 30 mg/kg of nicardipine (n = 6) as a positive control and saline (n = 6) as a negative control. Blood flow was monitored continuously for 0, 1, 3, 6 and 24 hours after treatment. Rats given 200 mg of the ethanol extract of Yamato Toki demonstrated significantly greater blood flow compared with control rats at 1 hour after treatment. An ethanol extract of Yamato Toki from Nara administrated orally can increase blood flow in SHRSP.

scholarly journals Vascular Reactivity ConcerningOrthosiphon stamineusBenth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Nurul Maizan Manshor ◽  
Aidiahmad Dewa ◽  
Mohd Zaini Asmawi ◽  
Zhari Ismail ◽  
Nadiah Razali ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Spontaneously Hypertensive Rats ◽  
Vascular Reactivity ◽  
Water Extract ◽  
Hypertensive Rats ◽  
Contractile Responses ◽  
Spontaneously Hypertensive ◽  
Orthosiphon Stamineus ◽  
Continuous Release

Orthosiphon stamineusBenth has been traditionally used to treat hypertension. The study aimed to investigate the vascular reactivity of water extract (WOS) and water : methanolic (1 : 1) extract (WMOS) ofOrthosiphon stamineusBenth and AT1receptors blocker in the mechanisms of antihypertensive mediated byα1-adrenergic receptor and EDNO and PGI2releases in the SHR aortic rings. SHR (230–280 g) were divided into four groups: control, WOS, WMOS, and losartan. After being fed orally for 14 days, the aorta was harvested and subjected to PE (10−9to 10−5 M) and ACh (10−9to 10−5 M) with and without L-NAME (100 µM) and indomethacin (10 µM), respectively. WOS, WMOS, and losartan significantly reduced the contractile responses to PE intact suggesting the importance of endothelium in vasorelaxation. Losartan significantly enhanced the ACh-induced vasorelaxation. L-NAME significantly inhibited the ACh-induced relaxation in all groups. Indomethacin enhanced ACh-induced vasorelaxation in WMOS. Collectively,Orthosiphon stamineusleaves extract reduced vasoconstriction responses by the alteration ofα1-adrenergic and AT1receptors activities. The involvement of EDNO releases was clearly observed in this plant. In WOS, PGI2releases might not participate in the ACh-induced vasorelaxation. However, in WMOS, enhancement of vasorelaxation possibly due to continuous release of PGI2.

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