Rhodiola-Water Extract Induces β-endorphin Secretion to Lower Blood Pressure in Spontaneously Hypertensive Rats

2012 ◽  
pp. n/a-n/a
Author(s):  
Wei-Jing Lee ◽  
Hsien-Hui Chung ◽  
Yung-Ze Cheng ◽  
Hung Jung Lin ◽  
Juei-Tang Cheng
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Water Extract ◽  
Lower Blood Pressure ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Lower Blood

Activation of Peripheral Opioid µ-Receptors in Blood Vessel May Lower Blood Pressure in Spontaneously Hypertensive Rats

Pharmacology ◽  
2011 ◽  
Vol 87 (5-6) ◽  
pp. 257-264 ◽  
Author(s):  
Zhih-Cherng Chen ◽  
Ja-Ping Shieh ◽  
Hsien-Hui Chung ◽  
Ching-Hsia Hung ◽  
Hung Jung Lin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Vessel ◽  
Spontaneously Hypertensive Rats ◽  
Lower Blood Pressure ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Lower Blood

scholarly journals Central DuP 753 does not lower blood pressure in spontaneously hypertensive rats.

Hypertension ◽  
1992 ◽  
Vol 19 (6_pt_2) ◽  
pp. 668-671 ◽  
Author(s):  
M J DePasquale ◽  
A A Fossa ◽  
W F Holt ◽  
M L Mangiapane
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Lower Blood Pressure ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Lower Blood

Standardized ethanol-water extract of Ficus deltoidea Angustifolia reduces blood pressure in spontaneously hypertensive rats

2019 ◽  
Vol 41 (5) ◽  
pp. 444-451
Author(s):  
Mohd Saleh Ahmad Kamal ◽  
Nor Hadiani Ismail ◽  
Nuraliza Abdul Satar ◽  
Norasikin Abdul Azis ◽  
Zurain Radjeni ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Water Extract ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Ficus Deltoidea

scholarly journals Auricular Acupuncture to Lower Blood Pressure Involves the Adrenal Gland in Spontaneously Hypertensive Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Huong Thi Mai Nguyen ◽  
Der-Yen Lee ◽  
Hung-Ming Wu ◽  
Ching-Liang Hsieh
Keyword(s):  
Blood Pressure ◽  
Adrenal Gland ◽  
Spontaneously Hypertensive Rats ◽  
Vagal Afferents ◽  
Auricular Acupuncture ◽  
Control Group ◽  
Hypertensive Rats ◽  
Gaba A ◽  
Spontaneously Hypertensive ◽  
Lower Blood

Auricular acupuncture is used to treat cardiac-related diseases such as hypertension. Therefore, the purpose of the present study was to investigate the effects of auricular acupuncture on blood pressure (BP) in spontaneously hypertensive rats (SHRs). The treatment group (TG) received auricular electroacupuncture (EA) at the auricle heart (CO15) and auricle shenmen (TEF3) points. Heart rate (HR) and BP, GABA-A expression, catecholamine, and neurotransmitter levels were measured. The HR was reduced after 7 auricular EA treatments compared with controls (all p < 0.05 ). Systolic BP and diastolic BP also decreased immediately and throughout the treatments compared with controls (all p < 0.05 ). The reduction of BP and HR was reversed by bicuculline injection 30 min before auricular EA treatment (all p < 0.05 ). GABA levels in the adrenal gland were higher with auricular EA treatment compared with the control group at 4 h ( p < 0.05 ). Levels of serum noradrenaline and adrenaline were reduced at 15 min after final auricular EA treatment compared with the normal control group (both p < 0.05 ). The lowering of BP and HR by auricular EA is possibly mediated via vagal afferents from the concha to the nucleus of the solitary tract. After signal integration in the medulla oblongata, it may be transmitted through sympathetic efferent or vagal efferent or through multiple signaling pathways simultaneously to the atrionector of heart and the adrenal medulla. Further study is warranted.

Heme oxygenase substrates acutely lower blood pressure in hypertensive rats

1996 ◽  
Vol 271 (3) ◽  
pp. H1132-H1138 ◽  
Author(s):  
R. A. Johnson ◽  
M. Lavesa ◽  
K. DeSeyn ◽  
M. J. Scholer ◽  
A. Nasjletti
Keyword(s):  
Blood Pressure ◽  
Carbon Monoxide ◽  
Heme Oxygenase ◽  
Lower Blood Pressure ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Free Iron ◽  
Spontaneously Hypertensive ◽  
Lower Blood ◽  
Wistar Kyoto

Heme oxygenase catalyzes the metabolism of heme to biliverdine, free iron, and carbon monoxide. The current study was designed to determine if treatment with the heme oxygenase substrates heme-L-arginate or heme-L-lysinate, to stimulate formation of heme oxygenase products, can lower blood pressure in the rat. Heme-L-arginate (45 mumol/kg ip) and heme-L-lysinate (45 mumol/kg ip) acutely lowered blood pressure in awake spontaneously hypertensive rats (SHR) by approximately 35 mmHg. For both heme oxygenase substrates, this effect was blunted by pretreatment with an inhibitor of heme oxygenase, zinc deuteroporphyrin 2,4-bis glycol. Heme-L-lysinate also lowered arterial pressure in deoxycorticosterone acetate-salt hypertensive rats and in rats with phenylephrine-induced hypertension, indicating that the vasodepressive actions of heme may be extended to other hypertensive models. However, neither heme-L-arginate nor heme-L-lysinate decreased blood pressure in normotensive controls. The heme oxygenase product biliverdine did not lower blood pressure in SHR, and the vasodepressive actions of heme-L-lysinate were unaffected by pretreatment with deferoxamine to chelate free iron. Carbon monoxide (12 ml/kg ip) lowered blood pressure in SHR and in rats made hypertensive by phenylephrine infusion, had no effect on blood pressure in Wistar-Kyoto rats, and elicited only a modest vasodepressive response in normotensive Sprague-Dawley rats. We conclude that heme-bearing preparations can lower blood pressure in hypertensive rats, presumably via heme oxygenase-mediated formation of carbon monoxide.

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