An experimental study in reducing blood pressure in spontaneously hypertensive rats through extracellular signal-regulated kinase inhibition

2010 ◽  
Vol 34 (8) ◽  
pp. S31-S31
Author(s):  
Li Jing ◽  
Jian‑zhong Zhang ◽  
Jin‑ping Sun ◽  
Xin An ◽  
Feng‑ying Guo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Experimental Study ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Kinase Inhibition ◽  
Spontaneously Hypertensive ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

Resveratrol prevents the development of high blood pressure in spontaneously hypertensive rats through the inhibition of enhanced expression of Giα proteins

2019 ◽  
Vol 97 (9) ◽  
pp. 872-879 ◽  
Author(s):  
Oli Sarkar ◽  
Yuan Li ◽  
Madhu B. Anand-Srivastava
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Cardiovascular Complications ◽  
Signaling Molecules ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Enhanced Expression

Resveratrol (RV), a polyphenolic component of red wine, has been shown to attenuate high blood pressure (BP) in spontaneously hypertensive rats (SHRs). We previously found that the enhanced expression of Giα proteins plays a role in the pathogenesis of hypertension in SHRs. In the present study, we investigated whether this RV-induced decrease in BP in SHRs can be attributed to the ability of RV to inhibit the enhanced expression of Giα proteins and the upstream signaling molecules implicated in the overexpression of Giα proteins. Administration of RV (50 mg/kg per day) to prehypertensive 2-week-old SHRs for 6 weeks prevented the development of high BP and inhibited the enhanced expression of Giα proteins, the enhanced levels of superoxide anion (O2−) and NADPH oxidase activity, the enhanced activation (phosphorylation) of c-Src and growth factor receptors, as well as the enhanced levels of extracellular signal-regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) exhibited by vascular smooth muscle cells isolated from SHRs. In conclusion, these results indicate that RV attenuates the development of high BP in SHRs through the inhibition of enhanced levels of Giα proteins, oxidative stress, and the upstream signaling molecules that contribute to the overexpression of Giα proteins. These findings suggest that RV could potentially be used as a therapeutic agent in the treatment of cardiovascular complications including hypertension.

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