scholarly journals The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence

Cell Cycle ◽  
2007 ◽  
Vol 6 (15) ◽  
pp. 1831-1836 ◽  
Author(s):  
Frédérick A. Mallette ◽  
Gerardo Ferbeyre
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Cellular Senescence ◽  
Dna Damage Signaling ◽  
Oncogenic Stress

Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells

2012 ◽  
Vol 52 (6) ◽  
pp. 311-317 ◽  
Author(s):  
Kaisar A. Talukder ◽  
Ishrat J. Azmi ◽  
K. Ahtesham Ahmed ◽  
M. Sabir Hossain ◽  
Yearul Kabir ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Shiga Toxin ◽  
Mammalian Cells ◽  
Dna Damage Signaling

Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA–PKcs and PARP-1

2012 ◽  
Vol 83 (6) ◽  
pp. 747-757 ◽  
Author(s):  
Jung-Hoon Yoon ◽  
Sang-Gun Ahn ◽  
Byung-Hoon Lee ◽  
Sung-Hoo Jung ◽  
Seon-Hee Oh
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling ◽  
Parp 1

scholarly journals Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells

2014 ◽  
Vol 70 (6) ◽  
pp. 701-713 ◽  
Author(s):  
Ran Gao ◽  
Rumani Singh ◽  
Zeenia Kaul ◽  
Sunil C. Kaul ◽  
Renu Wadhwa
Keyword(s):  
Dna Damage ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

2007 ◽  
Vol 21 (1) ◽  
pp. 43-48 ◽  
Author(s):  
F. A. Mallette ◽  
M.-F. Gaumont-Leclerc ◽  
G. Ferbeyre
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals Alteration of DNA damage signaling pathway profile in radiation-treated glioblastoma stem-like cells

2015 ◽  
Vol 10 (3) ◽  
pp. 1769-1774 ◽  
Author(s):  
CHAO SUN ◽  
ZHONGYONG WANG ◽  
WUCHAO SONG ◽  
BAOMIN CHEN ◽  
JINSHI ZHANG ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells

2007 ◽  
Vol 83 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Huda H. Al-Khalaf ◽  
Boleslaw Lach ◽  
Ayman Allam ◽  
Ahmed AlKhani ◽  
Salman A. Alrokayan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals Evidence of cellular senescence during the development of estrogen-induced pituitary tumors

2015 ◽  
Vol 22 (3) ◽  
pp. 299-317 ◽  
Author(s):  
Maria Eugenia Sabatino ◽  
Juan Pablo Petiti ◽  
Liliana del Valle Sosa ◽  
Pablo Anibal Pérez ◽  
Silvina Gutiérrez ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cellular Senescence ◽  
Pituitary Adenomas ◽  
Pituitary Tumors ◽  
Male Rats ◽  
Pituitary Cells ◽  
Dna Damage Signaling ◽  
Estrogen Exposure ◽  
Benign Nature

Although pituitary adenomas represent 25% of intracranial tumors, they are usually benign, with the mechanisms by which these tumors usually avoid an invasive profile and metastatic growth development still remaining unclear. In this context, cellular senescence might constitute a plausible explanation for the benign nature of pituitary adenomas. In this study, we investigated the emergence of cellular senescence as a growth control mechanism during the progression of estrogen-induced pituitary tumors. The quantification of Ki67-immunopositive cells in the pituitaries of estrogenized male rats after 10, 20, 40, and 60 days revealed that the mitogenic potential rate was not sustained for the whole period analyzed and successively decreased after 10 days of estrogen exposure. In addition, the expression of cellular senescence features, such as the progressive rise in the enzymatic senescence-associated b-galactosidase (SA-b-gal) activity, IL6, IL1b, and TGFb expression, was observed throughout pituitary tumor development. Furthermore, tumoral pituitary cells also displayed nuclear pATM expression, indicating activated DNA damage signaling, with a significant increase in p21 expression also being detected. The associations among DNA damage signaling activation, SA-b-gal expression, and p21 may provide a reliable combination of senescence-associated markers for in vivo pituitary senescence detection. These results suggest a role for this cellular process in the regulation of pituitary cell growth. Thus, cellular senescence should be conceived as a contributing component to the benign nature of pituitary adenomas, thereby influencing the capability of the pituitary gland to avoid unregulated cell proliferation.

Sign in / Sign up

Export Citation Format

Share Document