NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity

2011 ◽  
Vol 30 (3) ◽  
pp. 233-242 ◽  
Author(s):  
Yan Yan Hou ◽  
Meng Tiak Toh ◽  
Xueying Wang
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Genome Instability ◽  
Dna Damage Signaling

Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells

2012 ◽  
Vol 52 (6) ◽  
pp. 311-317 ◽  
Author(s):  
Kaisar A. Talukder ◽  
Ishrat J. Azmi ◽  
K. Ahtesham Ahmed ◽  
M. Sabir Hossain ◽  
Yearul Kabir ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Shiga Toxin ◽  
Mammalian Cells ◽  
Dna Damage Signaling

Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA–PKcs and PARP-1

2012 ◽  
Vol 83 (6) ◽  
pp. 747-757 ◽  
Author(s):  
Jung-Hoon Yoon ◽  
Sang-Gun Ahn ◽  
Byung-Hoon Lee ◽  
Sung-Hoo Jung ◽  
Seon-Hee Oh
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling ◽  
Parp 1

scholarly journals Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells

2014 ◽  
Vol 70 (6) ◽  
pp. 701-713 ◽  
Author(s):  
Ran Gao ◽  
Rumani Singh ◽  
Zeenia Kaul ◽  
Sunil C. Kaul ◽  
Renu Wadhwa
Keyword(s):  
Dna Damage ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

2007 ◽  
Vol 21 (1) ◽  
pp. 43-48 ◽  
Author(s):  
F. A. Mallette ◽  
M.-F. Gaumont-Leclerc ◽  
G. Ferbeyre
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals Alteration of DNA damage signaling pathway profile in radiation-treated glioblastoma stem-like cells

2015 ◽  
Vol 10 (3) ◽  
pp. 1769-1774 ◽  
Author(s):  
CHAO SUN ◽  
ZHONGYONG WANG ◽  
WUCHAO SONG ◽  
BAOMIN CHEN ◽  
JINSHI ZHANG ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells

2007 ◽  
Vol 83 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Huda H. Al-Khalaf ◽  
Boleslaw Lach ◽  
Ayman Allam ◽  
Ahmed AlKhani ◽  
Salman A. Alrokayan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation

2021 ◽  
Vol 220 (12) ◽  
Author(s):  
Delisa E. Clay ◽  
Heidi S. Bretscher ◽  
Erin A. Jezuit ◽  
Korie B. Bush ◽  
Donald T. Fox
Keyword(s):  
Dna Damage ◽  
Dna Polymerase ◽  
Chromosome Segregation ◽  
Genome Instability ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
End Joining ◽  
Strand Breaks ◽  
Dna Damage Signaling ◽  
Alternative End Joining

Cycling cells must respond to DNA double-strand breaks (DSBs) to avoid genome instability. Missegregation of chromosomes with DSBs during mitosis results in micronuclei, aberrant structures linked to disease. How cells respond to DSBs during mitosis is incompletely understood. We previously showed that Drosophilamelanogaster papillar cells lack DSB checkpoints (as observed in many cancer cells). Here, we show that papillar cells still recruit early acting repair machinery (Mre11 and RPA3) and the Fanconi anemia (FA) protein Fancd2 to DSBs. These proteins persist as foci on DSBs as cells enter mitosis. Repair foci are resolved in a stepwise manner during mitosis. DSB repair kinetics depends on both monoubiquitination of Fancd2 and the alternative end-joining protein DNA polymerase θ. Disruption of either or both of these factors causes micronuclei after DNA damage, which disrupts intestinal organogenesis. This study reveals a mechanism for how cells with inactive DSB checkpoints can respond to DNA damage that persists into mitosis.

scholarly journals The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence

Cell Cycle ◽  
2007 ◽  
Vol 6 (15) ◽  
pp. 1831-1836 ◽  
Author(s):  
Frédérick A. Mallette ◽  
Gerardo Ferbeyre
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Cellular Senescence ◽  
Dna Damage Signaling ◽  
Oncogenic Stress
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