scholarly journals The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

2007 ◽  
Vol 21 (1) ◽  
pp. 43-48 ◽  
Author(s):  
F. A. Mallette ◽  
M.-F. Gaumont-Leclerc ◽  
G. Ferbeyre
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells

2012 ◽  
Vol 52 (6) ◽  
pp. 311-317 ◽  
Author(s):  
Kaisar A. Talukder ◽  
Ishrat J. Azmi ◽  
K. Ahtesham Ahmed ◽  
M. Sabir Hossain ◽  
Yearul Kabir ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Shiga Toxin ◽  
Mammalian Cells ◽  
Dna Damage Signaling

Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA–PKcs and PARP-1

2012 ◽  
Vol 83 (6) ◽  
pp. 747-757 ◽  
Author(s):  
Jung-Hoon Yoon ◽  
Sang-Gun Ahn ◽  
Byung-Hoon Lee ◽  
Sung-Hoo Jung ◽  
Seon-Hee Oh
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling ◽  
Parp 1

scholarly journals Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells

2014 ◽  
Vol 70 (6) ◽  
pp. 701-713 ◽  
Author(s):  
Ran Gao ◽  
Rumani Singh ◽  
Zeenia Kaul ◽  
Sunil C. Kaul ◽  
Renu Wadhwa
Keyword(s):  
Dna Damage ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals Alteration of DNA damage signaling pathway profile in radiation-treated glioblastoma stem-like cells

2015 ◽  
Vol 10 (3) ◽  
pp. 1769-1774 ◽  
Author(s):  
CHAO SUN ◽  
ZHONGYONG WANG ◽  
WUCHAO SONG ◽  
BAOMIN CHEN ◽  
JINSHI ZHANG ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells

2007 ◽  
Vol 83 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Huda H. Al-Khalaf ◽  
Boleslaw Lach ◽  
Ayman Allam ◽  
Ahmed AlKhani ◽  
Salman A. Alrokayan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence

Cell Cycle ◽  
2007 ◽  
Vol 6 (15) ◽  
pp. 1831-1836 ◽  
Author(s):  
Frédérick A. Mallette ◽  
Gerardo Ferbeyre
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Cellular Senescence ◽  
Dna Damage Signaling ◽  
Oncogenic Stress

scholarly journals DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation

2006 ◽  
Vol 17 (4) ◽  
pp. 1583-1592 ◽  
Author(s):  
Olga Moiseeva ◽  
Frédérick A. Mallette ◽  
Utpal K. Mukhopadhyay ◽  
Adrian Moores ◽  
Gerardo Ferbeyre
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Transcriptional Activity ◽  
Oxygen Species ◽  
Interferon Β ◽  
Dna Damage Signaling ◽  
Cycle Arrest ◽  
Senescence Program ◽  
Serine 392 ◽  
Antiproliferative Activities

Interferons are cytokines with potent antiviral and antiproliferative activities. We report that although a transient exposure to β-interferon induces a reversible cell cycle arrest, a sustained treatment triggers a p53-dependent senescence program. β-Interferon switched on p53 in two steps. First, it induced the acetylation of p53 at lysine 320 and its dephosphorylation at serine 392 but not p53 activity. Later on, it triggered a DNA signaling pathway, the phosphorylation of p53 at serine 15 and its transcriptional activity. In agreement, β-interferon–treated cells accumulated γ-H2AX foci and phosphorylated forms of ATM and CHK2. The DNA damage signaling pathway was activated by an increase in reactive oxygen species (ROS) induced by interferon and was inhibited by the antioxidant N-acetyl cysteine. More important, RNA interference against ATM inhibited p53 phosphorylation at serine 15, p53 activity and senescence in response to β-interferon. β-Interferon–induced senescence was more efficient in cells expressing either, p53, or constitutive allele of ERK2 or RasV12. Hence, β-interferon–induced senescence targets preferentially cells with premalignant changes.

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