Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells

2012 ◽  
Vol 52 (6) ◽  
pp. 311-317 ◽  
Author(s):  
Kaisar A. Talukder ◽  
Ishrat J. Azmi ◽  
K. Ahtesham Ahmed ◽  
M. Sabir Hossain ◽  
Yearul Kabir ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Shiga Toxin ◽  
Mammalian Cells ◽  
Dna Damage Signaling

Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA–PKcs and PARP-1

2012 ◽  
Vol 83 (6) ◽  
pp. 747-757 ◽  
Author(s):  
Jung-Hoon Yoon ◽  
Sang-Gun Ahn ◽  
Byung-Hoon Lee ◽  
Sung-Hoo Jung ◽  
Seon-Hee Oh
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling ◽  
Parp 1

scholarly journals Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells

2014 ◽  
Vol 70 (6) ◽  
pp. 701-713 ◽  
Author(s):  
Ran Gao ◽  
Rumani Singh ◽  
Zeenia Kaul ◽  
Sunil C. Kaul ◽  
Renu Wadhwa
Keyword(s):  
Dna Damage ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

2007 ◽  
Vol 21 (1) ◽  
pp. 43-48 ◽  
Author(s):  
F. A. Mallette ◽  
M.-F. Gaumont-Leclerc ◽  
G. Ferbeyre
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals Alteration of DNA damage signaling pathway profile in radiation-treated glioblastoma stem-like cells

2015 ◽  
Vol 10 (3) ◽  
pp. 1769-1774 ◽  
Author(s):  
CHAO SUN ◽  
ZHONGYONG WANG ◽  
WUCHAO SONG ◽  
BAOMIN CHEN ◽  
JINSHI ZHANG ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells

2007 ◽  
Vol 83 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Huda H. Al-Khalaf ◽  
Boleslaw Lach ◽  
Ayman Allam ◽  
Ahmed AlKhani ◽  
Salman A. Alrokayan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Signaling

scholarly journals The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence

Cell Cycle ◽  
2007 ◽  
Vol 6 (15) ◽  
pp. 1831-1836 ◽  
Author(s):  
Frédérick A. Mallette ◽  
Gerardo Ferbeyre
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Cellular Senescence ◽  
Dna Damage Signaling ◽  
Oncogenic Stress

scholarly journals Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways

2001 ◽  
Vol 153 (3) ◽  
pp. 613-620 ◽  
Author(s):  
Irene Rappold ◽  
Kuniyoshi Iwabuchi ◽  
Takayasu Date ◽  
Junjie Chen
Keyword(s):  
Dna Damage ◽  
Tumor Suppressor ◽  
Signaling Pathways ◽  
Mammalian Cells ◽  
Binding Protein ◽  
Susceptibility Gene ◽  
Breast Cancer Susceptibility Gene ◽  
Tumor Suppressor P53 ◽  
Γ Radiation ◽  
Dna Damage Signaling

The tumor suppressor p53 binding protein 1 (53BP1) binds to the DNA-binding domain of p53 and enhances p53-mediated transcriptional activation. 53BP1 contains two breast cancer susceptibility gene 1 COOH terminus (BRCT) motifs, which are present in several proteins involved in DNA repair and/or DNA damage–signaling pathways. Thus, we investigated the potential role of 53BP1 in DNA damage–signaling pathways. Here, we report that 53BP1 becomes hyperphosphorylated and forms discrete nuclear foci in response to DNA damage. These foci colocalize at all time points with phosphorylated H2AX (γ-H2AX), which has been previously demonstrated to localize at sites of DNA strand breaks. 53BP1 foci formation is not restricted to γ-radiation but is also detected in response to UV radiation as well as hydroxyurea, camptothecin, etoposide, and methylmethanesulfonate treatment. Several observations suggest that 53BP1 is regulated by ataxia telangiectasia mutated (ATM) after DNA damage. First, ATM-deficient cells show no 53BP1 hyperphosphorylation and reduced 53BP1 foci formation in response to γ-radiation compared with cells expressing wild-type ATM. Second, wortmannin treatment strongly inhibits γ-radiation–induced hyperphosphorylation and foci formation of 53BP1. Third, 53BP1 is readily phosphorylated by ATM in vitro. Taken together, these results suggest that 53BP1 is an ATM substrate that is involved early in the DNA damage–signaling pathways in mammalian cells.

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