Biocompatibility matters: reducing the toxicity of nonviral vectors

2015 ◽  
pp. 116-128
Author(s):  
Yvette Pötzinger ◽  
Hannes Ahrem ◽  
Dagmar Fischer
Keyword(s):  
Nonviral Vectors

scholarly journals Biopolymeric Materials Used as Nonviral Vectors: A Review

2021 ◽  
Vol 2 (1) ◽  
pp. 100-109
Author(s):  
Jailson de Araújo Santos ◽  
Daniel Barbosa Liarte ◽  
Alessandra Braga Ribeiro ◽  
Marcia dos Santos Rizzo ◽  
Marcília Pinheiro da Costa ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Web Of Science ◽  
Gene Transfection ◽  
Genetic Material ◽  
Nonviral Vectors ◽  
Cationic Polymers ◽  
Genetic Trait ◽  
Low Diversity ◽  
Different Types ◽  
Materials Used

Bacterial transformation and gene transfection can be understood as being the results of introducing specific genetic material into cells, resulting in gene expression, and adding a new genetic trait to the host cell. Many studies have been carried out to investigate different types of lipids and cationic polymers as promising nonviral vectors for DNA transfer. The present study aimed to carry out a systematic review on the use of biopolymeric materials as nonviral vectors. The methodology was carried out based on searches of scientific articles and applications for patents published or deposited from 2006 to 2020 in different databases for patents (EPO, USPTO, and INPI) and articles (Scopus, Web of Science, and Scielo). The results showed that there are some deposits of patents regarding the use of chitosan as a gene carrier. The 16 analyzed articles allowed us to infer that the use of biopolymers as nonviral vectors is limited due to the low diversity of biopolymers used for these purposes. It was also observed that the use of different materials as nonviral vectors is based on chemical structure modifications of the material, mainly by the addition of cationic groups. Thus, the use of biopolymers as nonviral vectors is still limited to only a few polysaccharide types, emphasizing the need for further studies involving the use of different biopolymers in processes of gene transfer.

scholarly journals Complete tumor prevention by engineered tumor cell vaccines employing nonviral vectors

2003 ◽  
Vol 10 (12) ◽  
pp. 887-897 ◽  
Author(s):  
Inés Moret-Tatay ◽  
Joaquín Díaz ◽  
Francisco M Marco ◽  
Antonio Crespo ◽  
Salvador F Aliño
Keyword(s):  
Tumor Cell ◽  
Nonviral Vectors ◽  
Tumor Prevention ◽  
Tumor Cell Vaccines ◽  
Complete Tumor

Chitosan-Based Nonviral Vectors for Gene Delivery

2005 ◽  
pp. 817-836
Author(s):  
Wen Guang Liu ◽  
William Lu ◽  
Kang De Yao
Keyword(s):  
Gene Delivery ◽  
Nonviral Vectors

scholarly journals Poly(β-amino ester)-co -poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo

2018 ◽  
Vol 7 (14) ◽  
pp. 1800249 ◽  
Author(s):  
Umberto Capasso Palmiero ◽  
James C. Kaczmarek ◽  
Owen S. Fenton ◽  
Daniel G. Anderson
Keyword(s):  
Nonviral Vectors ◽  
Amino Ester ◽  
Poly Caprolactone

Viral and Nonviral Vectors for In Vivo and Ex Vivo Gene Therapies

2016 ◽  
pp. 155-177 ◽  
Author(s):  
A. Crespo-Barreda ◽  
M.M. Encabo-Berzosa ◽  
R. González-Pastor ◽  
P. Ortíz-Teba ◽  
M. Iglesias ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Nonviral Vectors ◽  
Gene Therapies

Dramatic influence of the hydroxy functionality of azasugar moiety in the head group region of tocopherol-based cationic lipids on in vitro gene transfection efficacies

2021 ◽  
Author(s):  
Venkanna Muripiti ◽  
Brijesh Lohchania ◽  
Venkatesh Ravula ◽  
Shireesha Manturthi ◽  
Srujan Marepally ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Cationic Lipids ◽  
Head Group ◽  
Nonviral Vectors

Cationic lipids have been effectively used as nonviral vectors for the delivery of polynucleic acids into the cytosol.

scholarly journals Gene Therapy Delivery Systems for Enhancing Viral and Nonviral Vectors for Cardiac Diseases: Current Concepts and Future Applications

2013 ◽  
Vol 24 (11) ◽  
pp. 914-927 ◽  
Author(s):  
Michael G. Katz ◽  
Anthony S. Fargnoli ◽  
Richard D. Williams ◽  
Charles R. Bridges
Keyword(s):  
Gene Therapy ◽  
Delivery Systems ◽  
Cardiac Diseases ◽  
Nonviral Vectors ◽  
Therapy Delivery

Nonviral Vectors for Gene Delivery

2009 ◽  
Vol 109 (2) ◽  
pp. 259-302 ◽  
Author(s):  
Meredith A. Mintzer ◽  
Eric E. Simanek
Keyword(s):  
Gene Delivery ◽  
Nonviral Vectors
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