Nonviral Vectors for Gene Therapy

2001 ◽  
Author(s):  
Mark A. Findeis
Keyword(s):  
Gene Therapy ◽  
Nonviral Vectors

scholarly journals Gene Therapy Delivery Systems for Enhancing Viral and Nonviral Vectors for Cardiac Diseases: Current Concepts and Future Applications

2013 ◽  
Vol 24 (11) ◽  
pp. 914-927 ◽  
Author(s):  
Michael G. Katz ◽  
Anthony S. Fargnoli ◽  
Richard D. Williams ◽  
Charles R. Bridges
Keyword(s):  
Gene Therapy ◽  
Delivery Systems ◽  
Cardiac Diseases ◽  
Nonviral Vectors ◽  
Therapy Delivery

scholarly journals Multicomponent nanoparticles as nonviral vectors for the treatment of Fabry disease by gene therapy

2012 ◽  
pp. 303 ◽  
Author(s):  
Aritz Perez Ruiz de Garibay ◽  
Delgado ◽  
Ana del Pozo ◽  
Mª Angeles Solinís ◽  
Alicia Rodriguez Gascón
Keyword(s):  
Gene Therapy ◽  
Fabry Disease ◽  
Nonviral Vectors

Current Status of Nonviral Vectors for Gene Therapy in China

2018 ◽  
Vol 29 (2) ◽  
pp. 110-120 ◽  
Author(s):  
Li Liu ◽  
Jingyun Yang ◽  
Ke Men ◽  
Zhiyao He ◽  
Min Luo ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Current Status ◽  
Nonviral Vectors

scholarly journals Nonviral Gene Therapy for Cancer: A Review

Diseases ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 57 ◽  
Author(s):  
Chiaki Hidai ◽  
Hisataka Kitano
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
Viral Vectors ◽  
Viral Vector ◽  
Transfer Efficiency ◽  
Nonviral Vectors ◽  
Apparent Lack ◽  
Gene Transfer Efficiency ◽  
Relative Safety

Although the development of effective viral vectors put gene therapy on the road to commercialization, nonviral vectors show promise for practical use because of their relative safety and lower cost. A significant barrier to the use of nonviral vectors, however, is that they have not yet proven effective. This apparent lack of interest can be attributed to the problem of the low gene transfer efficiency associated with nonviral vectors. The efficiency of gene transfer via nonviral vectors has been reported to be 1/10th to 1/1000th that of viral vectors. Despite the fact that new gene transfer methods and nonviral vectors have been developed, no significant improvements in gene transfer efficiency have been achieved. Nevertheless, some notable progress has been made. In this review, we discuss studies that report good results using nonviral vectors in vivo in animal models, with a particular focus on studies aimed at in vivo gene therapy to treat cancer, as this disease has attracted the interest of researchers developing nonviral vectors. We describe the conditions in which nonviral vectors work more efficiently for gene therapy and discuss how the goals might differ for nonviral versus viral vector development and use.

Gene Transfer Using Nonviral Delivery Systems

2006 ◽  
Vol 26 (6) ◽  
pp. 633-640 ◽  
Author(s):  
Masanobu Miyazaki ◽  
Yoko Obata ◽  
Katsushige Abe ◽  
Akira Furusu ◽  
Takehiko Koji ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Peritoneal Dialysis ◽  
Gene Transfer ◽  
Gene Delivery ◽  
Delivery System ◽  
Viral Vectors ◽  
Nonviral Vectors ◽  
Gene Delivery System ◽  
Peritoneal Membrane ◽  
Peritoneal Function

In peritoneal dialysis, loss of peritoneal function is a major factor in treatment failure. The alterations in peritoneal function are related to structural changes in the peritoneal membrane, including peritoneal sclerosis with increased extracellular matrix. Although peritoneal sclerosis is considered reversible to some extent through peritoneal rest, which improves peritoneal function and facilitates morphological changes, there has been no therapeutic intervention and no drug against the development and progression of peritoneal sclerosis. Using recent biotechnological advances in genetic engineering, a strategy based on genetic modification of the peritoneal membrane could be a potential therapeutic maneuver against peritoneal sclerosis and peritoneal membrane failure. Before this gene therapy may be applied clinically, a safe and effective gene delivery system as well as the selection of a gene therapy method must be established. There are presently two kinds of gene transfer vectors: viral and nonviral. Viral vectors are used mainly as a gene delivery system in the field of continuous ambulatory peritoneal dialysis research; however, they have several problems such as immunogenicity and toxicity. On the other hand, nonviral vectors have several advantages over viral vectors. We review here gene transfer using nonviral vector systems in the peritoneum: electroporation, liposomes, and cationized gelatin microspheres. In the field of peritoneal dialysis, gene therapy research using nonviral vectors is presently limited. Improvement in delivery methods together with an intelligent design of targeted genes has brought about large degrees of enhancement in the efficiency, specificity, and temporal control of nonviral vectors.

Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy in vivo

2010 ◽  
Vol 10 (2) ◽  
pp. 126-137 ◽  
Author(s):  
Jinfeng Xing ◽  
Liandong Deng ◽  
Shutao Guo ◽  
Anjie Dong ◽  
Xing-Jie Liang
Keyword(s):  
Gene Therapy ◽  
Nonviral Vectors

scholarly journals Dendrons with Spermine Surface Groups as Potential Building Blocks for Nonviral Vectors in Gene Therapy

2006 ◽  
Vol 17 (1) ◽  
pp. 172-178 ◽  
Author(s):  
John G. Hardy ◽  
Mauri A. Kostiainen ◽  
David K. Smith ◽  
Nathan P. Gabrielson ◽  
Daniel W. Pack
Keyword(s):  
Gene Therapy ◽  
Building Blocks ◽  
Surface Groups ◽  
Nonviral Vectors
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