Therapeutic Delivery Methods: A Concise Overview of Emerging Areas

2013 ◽  
Author(s):  
Beom-Jin Lee
Keyword(s):  
Delivery Methods ◽  
Therapeutic Delivery ◽  
Concise Overview

scholarly journals BH3-mimetics: recent developments in cancer therapy

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Paul A. Townsend ◽  
Maria V. Kozhevnikova ◽  
Olivier N. F. Cexus ◽  
Andrey A. Zamyatnin ◽  
Surinder M. Soond
Keyword(s):  
Protein Interactions ◽  
Tissue Homeostasis ◽  
Protein Protein Interactions ◽  
Delivery Methods ◽  
Apoptosis Pathway ◽  
Bh3 Mimetics ◽  
Treatment Regimens ◽  
Therapeutic Delivery ◽  
Pathological Conditions ◽  
Recent Developments

AbstractThe hopeful outcomes from 30 years of research in BH3-mimetics have indeed served a number of solid paradigms for targeting intermediates from the apoptosis pathway in a variety of diseased states. Not only have such rational approaches in drug design yielded several key therapeutics, such outputs have also offered insights into the integrated mechanistic aspects of basic and clinical research at the genetics level for the future. In no other area of medical research have the effects of such work been felt, than in cancer research, through targeting the BAX-Bcl-2 protein-protein interactions. With these promising outputs in mind, several mimetics, and their potential therapeutic applications, have also been developed for several other pathological conditions, such as cardiovascular disease and tissue fibrosis, thus highlighting the universal importance of the intrinsic arm of the apoptosis pathway and its input to general tissue homeostasis. Considering such recent developments, and in a field that has generated so much scientific interest, we take stock of how the broadening area of BH3-mimetics has developed and diversified, with a focus on their uses in single and combined cancer treatment regimens and recently explored therapeutic delivery methods that may aid the development of future therapeutics of this nature.

Therapeutic delivery using gene-delivery methods

2011 ◽  
Vol 2 (4) ◽  
pp. 423-426 ◽  
Author(s):  
Seppo Ylä-Herttuala ◽  
Thomas Wirth
Keyword(s):  
Gene Delivery ◽  
Delivery Methods ◽  
Therapeutic Delivery

Effectiveness of Three Training Delivery Methods in a Voluntary Program

2009 ◽  
Author(s):  
Arash Salehi ◽  
Lesley Strawderman ◽  
Yunchen Huang ◽  
Shaheen Ahmed ◽  
Kari Babski-Reeves
Keyword(s):  
Delivery Methods ◽  
Voluntary Program ◽  
Training Delivery

Integration of Alternative Technical Concepts with Innovative Delivery Methods

2020 ◽  
Author(s):  
Yifeng Tian ◽  
R. Edward Minchin ◽  
Yuanxin Zhang ◽  
Congwen Kan
Keyword(s):  
Delivery Methods

Nonlinear dynamics of a shell encapsulated microbubble near solid boundary in an ultrasonic field

2020 ◽  
Vol 14 (3) ◽  
pp. 7235-7243
Author(s):  
N.M. Ali ◽  
F. Dzaharudin ◽  
E.A. Alias
Keyword(s):  
Oscillation Amplitude ◽  
Ultrasonic Field ◽  
Dynamical Behaviour ◽  
Ultrasound Contrast Agents ◽  
Chaotic Behaviour ◽  
Solid Boundary ◽  
Driving Frequency ◽  
Pressure Amplitude ◽  
Radial Expansion ◽  
Therapeutic Delivery

Microbubbles have the potential to be used for diagnostic imaging and therapeutic delivery. However, the transition from microbubbles currently being used as ultrasound contrast agents to achieve its’ potentials in the biomedical field requires more in depth understanding. Of particular importance is the influence of microbubble encapsulation of a microbubble near a vessel wall on the dynamical behaviour as it stabilizes the bubble. However, many bubble studies do not consider shell encapsulation in their studies. In this work, the dynamics of an encapsulated microbubble near a boundary was studied by numerically solving the governing equations for microbubble oscillation. In order to elucidate the effects of a boundary to the non-linear microbubble oscillation the separation distances between microbubble will be varied along with the acoustic driving. The complex nonlinear vibration response was studied in terms of bifurcation diagrams and the maximum radial expansion. It was found that the increase in distance between the boundary and the encapsulated bubble will increase the oscillation amplitude. When the value of pressure amplitude increased the single bubble is more likely to exhibit the chaotic behaviour and maximum radius also increase as the inter wall-bubble distance is gradually increased. While, with higher driving frequency the maximum radial expansion decreases and suppress the chaotic behaviour.

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