Cutting-edge techniques for molecular imaging with relevance to therapeutic delivery methods

2013 ◽  
pp. 126-144
Author(s):  
Viness Pillay ◽  
Pradeep Kumar ◽  
Yahya E Choonara
Keyword(s):  
Molecular Imaging ◽  
Cutting Edge ◽  
Delivery Methods ◽  
Therapeutic Delivery

scholarly journals BH3-mimetics: recent developments in cancer therapy

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Paul A. Townsend ◽  
Maria V. Kozhevnikova ◽  
Olivier N. F. Cexus ◽  
Andrey A. Zamyatnin ◽  
Surinder M. Soond
Keyword(s):  
Protein Interactions ◽  
Tissue Homeostasis ◽  
Protein Protein Interactions ◽  
Delivery Methods ◽  
Apoptosis Pathway ◽  
Bh3 Mimetics ◽  
Treatment Regimens ◽  
Therapeutic Delivery ◽  
Pathological Conditions ◽  
Recent Developments

AbstractThe hopeful outcomes from 30 years of research in BH3-mimetics have indeed served a number of solid paradigms for targeting intermediates from the apoptosis pathway in a variety of diseased states. Not only have such rational approaches in drug design yielded several key therapeutics, such outputs have also offered insights into the integrated mechanistic aspects of basic and clinical research at the genetics level for the future. In no other area of medical research have the effects of such work been felt, than in cancer research, through targeting the BAX-Bcl-2 protein-protein interactions. With these promising outputs in mind, several mimetics, and their potential therapeutic applications, have also been developed for several other pathological conditions, such as cardiovascular disease and tissue fibrosis, thus highlighting the universal importance of the intrinsic arm of the apoptosis pathway and its input to general tissue homeostasis. Considering such recent developments, and in a field that has generated so much scientific interest, we take stock of how the broadening area of BH3-mimetics has developed and diversified, with a focus on their uses in single and combined cancer treatment regimens and recently explored therapeutic delivery methods that may aid the development of future therapeutics of this nature.

Therapeutic delivery using gene-delivery methods

2011 ◽  
Vol 2 (4) ◽  
pp. 423-426 ◽  
Author(s):  
Seppo Ylä-Herttuala ◽  
Thomas Wirth
Keyword(s):  
Gene Delivery ◽  
Delivery Methods ◽  
Therapeutic Delivery

scholarly journals A Review of the Applications of Biochemicals Interference in Medical Imaging with the Synthesis of Contrast Nanoparticles and Marker Design (PROBE)

2021 ◽  
Vol 12 (2) ◽  
pp. 2251-2261
Keyword(s):  
Quantum Dots ◽  
Content Analysis ◽  
Molecular Imaging ◽  
Contrast Agents ◽  
High Volume ◽  
High Contrast ◽  
Delivery Methods ◽  
Cellular Processes ◽  
Content Analysis Method ◽  
Marker Design

One of the main focuses in diagnostic medicine is molecular imaging. Nanoparticles allow us to image different components of a high-contrast molecule efficiently. In this study, various factors that should be considered when synthesizing contrast nanoparticles are discussed. Some of the most important examples are highlighted. This research has been done theoretically and in terms of content analysis method (Content Analysis) by searching for keywords nanotechnology, molecular imaging, drug delivery methods, gene therapy, and contrast nanoparticles in google, PubMed, Science direct, scholar, and Scopus websites. After the search, ten articles were selected from the obtained articles, and this article was written based on them. Most of the report’s nanoparticles produce new contrast agents, especially molecular imaging and cellular processes detection. Have been taken. The advantages of using these nanoparticles are the ability to produce high contrast, ease of integration of multiple properties, long circulation time in the blood, and the ability to carry high-volume materials (such as drugs). The basics and nanoparticle production methods have grown and expanded over the years, so more complex examples of nanoscale contrast agents such as paramagnetic particles, macrophages with quantum dots, quantum dots, machines that can make matter Atomic and molecular parts have been reported. MRI of microemulsions has also been used to examine blood vessels and deliver medication. The use of contrast nanoparticles provides more details about the processes of a disease and its effects. The fabrication of these materials has improved dramatically over the past decade by creating various functions in them. However, there are many areas for biocompatibility, efficacy, specificity, and diagnosis of further diseases. In general, contrast nanoparticles can be synthesized for a specific function, with specific properties to perform a specific program.

Plastic Deformation in Microtomed Sections

1971 ◽  
Vol 29 ◽  
pp. 458-459
Author(s):  
J. Temple Black
Keyword(s):  
Plastic Deformation ◽  
Plastic Strain ◽  
Applied Stress ◽  
Elastic Strain ◽  
High Strain ◽  
Tool Material ◽  
Cutting Edge ◽  
Material Structure ◽  
Geometrical Constraints

The output of the ultramicrotomy process with its high strain levels is dependent upon the input, ie., the nature of the material being machined. Apart from the geometrical constraints offered by the rake and clearance faces of the tool, each material is free to deform in whatever manner necessary to satisfy its material structure and interatomic constraints. Noncrystalline materials appear to survive the process undamaged when observed in the TEM. As has been demonstrated however microtomed plastics do in fact suffer damage to the top and bottom surfaces of the section regardless of the sharpness of the cutting edge or the tool material. The energy required to seperate the section from the block is not easily propogated through the section because the material is amorphous in nature and has no preferred crystalline planes upon which defects can move large distances to relieve the applied stress. Thus, the cutting stresses are supported elastically in the internal or bulk and plastically in the surfaces. The elastic strain can be recovered while the plastic strain is not reversible and will remain in the section after cutting is complete.

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