scholarly journals A CASE OF PULMONARY NODULES OF BENIGN METASTASIZING LEIOMYOMA OF THE UTERUS RESECTED UNDER THORACOSCOPIC SURGERY

1995 ◽  
Vol 56 (4) ◽  
pp. 820-823
Author(s):  
Mineo ASAOKA ◽  
Michio SASAKI ◽  
Hiroshi MASUMOTO ◽  
Akira SEKI
Keyword(s):  
Thoracoscopic Surgery ◽  
Pulmonary Nodules ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma ◽  
Leiomyoma Of The Uterus

scholarly journals An Unusual Cause of Pulmonary Nodules in the Emergency Department

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Ryan Yu ◽  
Melanie Ferri
Keyword(s):  
Emergency Department ◽  
Smooth Muscle ◽  
Clinical Presentation ◽  
Pulmonary Nodules ◽  
Pleuritic Chest Pain ◽  
Benign Metastasizing Leiomyoma ◽  
Spindle Cells ◽  
Smooth Muscle Tumors ◽  
Metastasizing Leiomyoma ◽  
Tomography Scan

We report a 51-year-old woman who presented to the emergency department with left-sided pleuritic chest pain 2 weeks after subtotal hysterectomy and bilateral salpingo-oophorectomy for a leiomyomatous uterus. Computed tomography scan of the chest revealed bilateral pulmonary nodules. Biopsy showed cytologically bland spindle cells without overt malignant features. Immunohistochemistry confirmed smooth muscle phenotype, in keeping with a clinicopathologic diagnosis of benign metastasizing leiomyoma (BML). BML does not frequently come to the attention of the emergency physician because it is rare and usually asymptomatic. When symptomatic, its clinical presentation depends on the site(s) of metastasis, number, and size of the smooth muscle tumors. Emergent presentations of BML are reviewed.

scholarly journals Benign Metastatic Leiomyoma Presenting as a Hemothorax

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Anna M. Ponea ◽  
Creticus P. Marak ◽  
Harmeen Goraya ◽  
Achuta K. Guddati
Keyword(s):  
Bone Marrow ◽  
Respiratory Failure ◽  
Hormonal Therapy ◽  
Skeletal Muscles ◽  
Pulmonary Nodules ◽  
Immunohistochemical Analysis ◽  
Lung Parenchyma ◽  
Molecular Profiling ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

Uterine leiomyomas have been reported to metastasize to various organs including the lungs, skeletal muscles, bone marrow, peritoneum, and heart. They may present with symptoms related to the metastases several years after hysterectomy. These tumors regress after menopause, and it is rare to detect active tumors in postmenopausal women. Despite their ability to metastasize, they are considered to be benign due to the lack of anaplasia. Pulmonary benign metastasizing leiomyoma is usually detected in the form of pulmonary nodules incidentally on imaging. Tissue biopsy of these nodules is required to identify them as benign metastasizing leiomyomas. Immunohistochemical analysis and molecular profiling may further help detect any malignant transformation in it. Untreated pulmonary benign metastasizing leiomyoma may result in the formation of cystic structures, destruction of lung parenchyma, and hemothorax and may cause respiratory failure. Surgical resection and hormonal therapy help prevent progression of this disease and provide an avenue for a cure.

Benign Metastasizing Leiomyoma of the Uterus

1999 ◽  
Vol 123 (10) ◽  
pp. 960-962 ◽  
Author(s):  
Jose M. Esteban ◽  
Warren M. Allen ◽  
Raymond H. Schaerf
Keyword(s):  
Low Grade ◽  
Benign Metastasizing Leiomyoma ◽  
Nuclear Pleomorphism ◽  
Benign Leiomyoma ◽  
Histopathologic Evaluation ◽  
Primary Neoplasm ◽  
Metastasizing Leiomyoma ◽  
Immunohistochemical Studies ◽  
Leiomyoma Of The Uterus ◽  
Rule Out

Abstract Benign uterine leiomyoma metastasizing to the lung is a recognized entity that has been reported infrequently in the medical literature. There is persisting controversy regarding the pathogenesis and biology of these lesions. We report a well-studied and well-characterized case of benign leiomyoma metastasizing to the lung. The patient was a 72-year-old woman with an enlarged uterus that contained several leiomyomas with usual histology. Areas of fibrosis, hyalinization, edema, and focal infarction together with small foci with mildly increased cellularity and minimal nuclear pleomorphism were seen. Careful and repeated mitotic counts ranged from 0 to 2 mitoses per 10 high-power fields. In summary, based on histopathologic criteria, the neoplasm was determined to be a focally cellular benign leiomyoma. Four years later, the patient underwent surgical resection of a single nodule in the lung, which had been detected on routine radiographs. Histopathologic evaluation showed a low-grade leiomyosarcoma with moderate nuclear pleomorphism, necrosis, and brisk mitotic activity. Immunohistochemical studies performed on both neoplasms showed them to be of mesenchymal derivation with smooth muscle differentiation. Both neoplasms expressed estrogen receptors with moderate to strong intensity. The patient received no further treatment and, to date, shows no evidence of recurrent disease. The diagnosis of benign metastasizing leiomyoma can only be made with certainty after careful and extensive sampling of the primary tumor to exclude small foci of sarcoma and of the pulmonary tumor to rule out a primary neoplasm. Although it is biologically peculiar, benign metastasizing leiomyoma should continue to be recognized as a distinct entity because current morphologic criteria do not allow primary myometrial tumors to be reclassified as leiomyomas of uncertain malignant potential even if they have metastasized to the lung.

Pulmonary Benign Metastasizing Leiomyoma, a Rare Cause of Pulmonary Nodules

2016 ◽  
Vol 52 (4) ◽  
pp. 226-227
Author(s):  
Patricia Pérez-Ferrer ◽  
Eusebi Chiner ◽  
José Norberto Sancho-Chust ◽  
Mar Arlandis
Keyword(s):  
Pulmonary Nodules ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

scholarly journals Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Maria Inês Raposo ◽  
Catarina Meireles ◽  
Mariana Cardoso ◽  
Mariana Ormonde ◽  
Cristina Ramalho ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Rare Condition ◽  
Gynecological Surgery ◽  
Benign Metastasizing Leiomyoma ◽  
Radiological Features ◽  
Genetic Patterns ◽  
Rare Manifestation ◽  
Metastasizing Leiomyoma ◽  
Work Up ◽  
Leiomyoma Of The Uterus

Benign Metastasizing Leiomyoma (BML) is a rare condition with few cases reported in the literature. It is usually incidentally diagnosed several years after a primary gynecological surgery for uterine leiomyoma. Differential diagnosis of BML is complex requiring an extensive work-up and exclusion of malignancy. Here, we report two cases of BML based on similarity of histopathological, immunohistochemical, and genetic patterns between lung nodules and uterine leiomyoma previously resected, evidencing the variability of clinical and radiological features of BML. We highlight the importance of 19q and 22q deletions as highly suggestive of BML. These findings are particularly relevant when there is no uterine sample for review.

scholarly journals Benign Metastasizing Leiomyoma: A Rare Type of Lung Metastases—Two Case Reports and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Rokana Taftaf ◽  
Sandra Starnes ◽  
Jiang Wang ◽  
Ralph Shipley ◽  
Tariq Namad ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Progesterone Receptors ◽  
Pulmonary Nodules ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Benign Metastasizing Leiomyoma ◽  
Ct Guided ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rare disease that usually occurs in women of reproductive age. They typically have history of uterine leiomyoma treated with hysterectomy. BML can metastasize to distant organs, with the lung being the most common organ. We report two patients who presented with benign metastasizing leiomyoma to the lung. Our first case was a fifty-two-year-old female who presented with multiple lung masses, with a past medical history of uterine leiomyoma who underwent hysterectomy 17 years ago. A CT-guided biopsy showed benign appearing spindle cells and pathology confirmed her diagnosis with additional positive estrogen/progesterone receptor stains. Our second case was a fifty-six-year-old female who presented with multiple cavitary pulmonary nodules. She subsequently underwent a video-assisted thoracoscopic surgery (VATS) with wedge resection of one of the nodules. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining strongly positive for estrogen/progesterone receptors. Benign metastasizing leiomyoma is a rare condition which may affect women of reproductive age. This should be considered in the differential in patients who present with multiple pulmonary nodules, especially with a history of uterine leiomyoma. Additional stains, such as estrogen/progesterone receptors, may need to be done to confirm the diagnosis.

scholarly journals Disseminated peritoneal leiomyomatosis – a rare complication of laparoscopic myomectomy with intraperitoneal morcellation

Oncoreview ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 113-116
Author(s):  
Grzegorz Kade ◽  
Sebastian Spaleniak ◽  
Emilia Frankowska ◽  
Szczepan Cierniak ◽  
Agnieszka Gąsowska-Bodnar ◽  
...  
Keyword(s):  
Female Patient ◽  
Rare Complication ◽  
Laparoscopic Myomectomy ◽  
Benign Metastasizing Leiomyoma ◽  
Disseminated Peritoneal Leiomyomatosis ◽  
Metastasizing Leiomyoma ◽  
Leiomyoma Of The Uterus

The present study reports the case of a 43-year-old female patient who presented with pulmonary benign metastasizing leiomyoma after a hysterectomy due to for leiomyoma of the uterus.

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