scholarly journals Molecular Profiling of Benign Metastasizing Leiomyoma of the Uterus Revealing Unique Novel Therapeutic Targets

Cureus ◽  
2020 ◽  
Author(s):  
Dawood Findakly ◽  
Jue Wang
Keyword(s):  
Therapeutic Targets ◽  
Molecular Profiling ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma ◽  
Leiomyoma Of The Uterus ◽  
Novel Therapeutic

scholarly journals Benign Metastatic Leiomyoma Presenting as a Hemothorax

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Anna M. Ponea ◽  
Creticus P. Marak ◽  
Harmeen Goraya ◽  
Achuta K. Guddati
Keyword(s):  
Bone Marrow ◽  
Respiratory Failure ◽  
Hormonal Therapy ◽  
Skeletal Muscles ◽  
Pulmonary Nodules ◽  
Immunohistochemical Analysis ◽  
Lung Parenchyma ◽  
Molecular Profiling ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

Uterine leiomyomas have been reported to metastasize to various organs including the lungs, skeletal muscles, bone marrow, peritoneum, and heart. They may present with symptoms related to the metastases several years after hysterectomy. These tumors regress after menopause, and it is rare to detect active tumors in postmenopausal women. Despite their ability to metastasize, they are considered to be benign due to the lack of anaplasia. Pulmonary benign metastasizing leiomyoma is usually detected in the form of pulmonary nodules incidentally on imaging. Tissue biopsy of these nodules is required to identify them as benign metastasizing leiomyomas. Immunohistochemical analysis and molecular profiling may further help detect any malignant transformation in it. Untreated pulmonary benign metastasizing leiomyoma may result in the formation of cystic structures, destruction of lung parenchyma, and hemothorax and may cause respiratory failure. Surgical resection and hormonal therapy help prevent progression of this disease and provide an avenue for a cure.

Benign Metastasizing Leiomyoma of the Uterus

1999 ◽  
Vol 123 (10) ◽  
pp. 960-962 ◽  
Author(s):  
Jose M. Esteban ◽  
Warren M. Allen ◽  
Raymond H. Schaerf
Keyword(s):  
Low Grade ◽  
Benign Metastasizing Leiomyoma ◽  
Nuclear Pleomorphism ◽  
Benign Leiomyoma ◽  
Histopathologic Evaluation ◽  
Primary Neoplasm ◽  
Metastasizing Leiomyoma ◽  
Immunohistochemical Studies ◽  
Leiomyoma Of The Uterus ◽  
Rule Out

Abstract Benign uterine leiomyoma metastasizing to the lung is a recognized entity that has been reported infrequently in the medical literature. There is persisting controversy regarding the pathogenesis and biology of these lesions. We report a well-studied and well-characterized case of benign leiomyoma metastasizing to the lung. The patient was a 72-year-old woman with an enlarged uterus that contained several leiomyomas with usual histology. Areas of fibrosis, hyalinization, edema, and focal infarction together with small foci with mildly increased cellularity and minimal nuclear pleomorphism were seen. Careful and repeated mitotic counts ranged from 0 to 2 mitoses per 10 high-power fields. In summary, based on histopathologic criteria, the neoplasm was determined to be a focally cellular benign leiomyoma. Four years later, the patient underwent surgical resection of a single nodule in the lung, which had been detected on routine radiographs. Histopathologic evaluation showed a low-grade leiomyosarcoma with moderate nuclear pleomorphism, necrosis, and brisk mitotic activity. Immunohistochemical studies performed on both neoplasms showed them to be of mesenchymal derivation with smooth muscle differentiation. Both neoplasms expressed estrogen receptors with moderate to strong intensity. The patient received no further treatment and, to date, shows no evidence of recurrent disease. The diagnosis of benign metastasizing leiomyoma can only be made with certainty after careful and extensive sampling of the primary tumor to exclude small foci of sarcoma and of the pulmonary tumor to rule out a primary neoplasm. Although it is biologically peculiar, benign metastasizing leiomyoma should continue to be recognized as a distinct entity because current morphologic criteria do not allow primary myometrial tumors to be reclassified as leiomyomas of uncertain malignant potential even if they have metastasized to the lung.

scholarly journals Molecular Profiling of Thymoma and Thymic Carcinoma: Genetic Differences and Potential Novel Therapeutic Targets

2016 ◽  
Vol 23 (3) ◽  
pp. 551-564 ◽  
Author(s):  
Franz Enkner ◽  
Bettina Pichlhöfer ◽  
Alexandru Teodor Zaharie ◽  
Milica Krunic ◽  
Tina Maria Holper ◽  
...  
Keyword(s):  
Thymic Carcinoma ◽  
Therapeutic Targets ◽  
Molecular Profiling ◽  
Genetic Differences ◽  
Novel Therapeutic

scholarly journals Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Maria Inês Raposo ◽  
Catarina Meireles ◽  
Mariana Cardoso ◽  
Mariana Ormonde ◽  
Cristina Ramalho ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Rare Condition ◽  
Gynecological Surgery ◽  
Benign Metastasizing Leiomyoma ◽  
Radiological Features ◽  
Genetic Patterns ◽  
Rare Manifestation ◽  
Metastasizing Leiomyoma ◽  
Work Up ◽  
Leiomyoma Of The Uterus

Benign Metastasizing Leiomyoma (BML) is a rare condition with few cases reported in the literature. It is usually incidentally diagnosed several years after a primary gynecological surgery for uterine leiomyoma. Differential diagnosis of BML is complex requiring an extensive work-up and exclusion of malignancy. Here, we report two cases of BML based on similarity of histopathological, immunohistochemical, and genetic patterns between lung nodules and uterine leiomyoma previously resected, evidencing the variability of clinical and radiological features of BML. We highlight the importance of 19q and 22q deletions as highly suggestive of BML. These findings are particularly relevant when there is no uterine sample for review.

scholarly journals Disseminated peritoneal leiomyomatosis – a rare complication of laparoscopic myomectomy with intraperitoneal morcellation

Oncoreview ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 113-116
Author(s):  
Grzegorz Kade ◽  
Sebastian Spaleniak ◽  
Emilia Frankowska ◽  
Szczepan Cierniak ◽  
Agnieszka Gąsowska-Bodnar ◽  
...  
Keyword(s):  
Female Patient ◽  
Rare Complication ◽  
Laparoscopic Myomectomy ◽  
Benign Metastasizing Leiomyoma ◽  
Disseminated Peritoneal Leiomyomatosis ◽  
Metastasizing Leiomyoma ◽  
Leiomyoma Of The Uterus

The present study reports the case of a 43-year-old female patient who presented with pulmonary benign metastasizing leiomyoma after a hysterectomy due to for leiomyoma of the uterus.

scholarly journals Benign Metastasizing Leiomyoma of the Uterus with Pulmonary and Bone Metastases

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Parikshit Padhi ◽  
Margarita Topalovski
Keyword(s):  
Motor Vehicle ◽  
Motor Vehicle Accident ◽  
Rare Condition ◽  
Middle Aged ◽  
Benign Metastasizing Leiomyoma ◽  
Spindle Cell Neoplasm ◽  
Aged Woman ◽  
History Of ◽  
Metastasizing Leiomyoma ◽  
Leiomyoma Of The Uterus

Benign metastasizing leiomyoma (BML) is a rare spindle cell neoplasm seen in middle-aged women who have a history of leiomyoma of the uterus. The most common sites of metastases are the lungs; however, other sites of spread have been documented. These tumors by definition have no malignant features on histology and tend to be estrogen and progesterone positive. We present a middle-aged woman who was incidentally found to have multiple pulmonary nodules and a mass on her sternum after she was involved in a motor vehicle accident. She had a history of uterine leiomyoma and had undergone a hysterectomy ten years prior to the accident. Biopsies were performed of the lung nodules and sternum mass and compared to her hysterectomy specimen, and they were identical, and hence, she was diagnosed with BML. Due to the growing tumor of her sternum, she was started on tamoxifen with stability of her tumors. These tumors, since they are benign, tend to have an indolent course. However, in the instances that treatment is warranted, options include surgery or antiestrogen therapy. We will be discussing the pathogenesis, histological findings, and treatment options of this rare condition. Our case is unique because BML in general do not tend to spread to multiple organs and tend to be limited to one site of disease.

scholarly journals Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling

2019 ◽  
Vol 8 (17) ◽  
pp. 7322-7329 ◽  
Author(s):  
Stacey M. Gargano ◽  
Wijendra Senarathne ◽  
Rebecca Feldman ◽  
Elena Florento ◽  
Phillip Stafford ◽  
...  
Keyword(s):  
Therapeutic Targets ◽  
Molecular Profiling ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Novel Therapeutic

Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases

2000 ◽  
Vol 437 (3) ◽  
pp. 284-292 ◽  
Author(s):  
K. Kayser ◽  
Stefan Zink ◽  
Thomas Schneider ◽  
Hendrik Dienemann ◽  
Sabine André ◽  
...  
Keyword(s):  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma ◽  
Leiomyoma Of The Uterus
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