scholarly journals An Unusual Cause of Pulmonary Nodules in the Emergency Department

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Ryan Yu ◽  
Melanie Ferri
Keyword(s):  
Emergency Department ◽  
Smooth Muscle ◽  
Clinical Presentation ◽  
Pulmonary Nodules ◽  
Pleuritic Chest Pain ◽  
Benign Metastasizing Leiomyoma ◽  
Spindle Cells ◽  
Smooth Muscle Tumors ◽  
Metastasizing Leiomyoma ◽  
Tomography Scan

We report a 51-year-old woman who presented to the emergency department with left-sided pleuritic chest pain 2 weeks after subtotal hysterectomy and bilateral salpingo-oophorectomy for a leiomyomatous uterus. Computed tomography scan of the chest revealed bilateral pulmonary nodules. Biopsy showed cytologically bland spindle cells without overt malignant features. Immunohistochemistry confirmed smooth muscle phenotype, in keeping with a clinicopathologic diagnosis of benign metastasizing leiomyoma (BML). BML does not frequently come to the attention of the emergency physician because it is rare and usually asymptomatic. When symptomatic, its clinical presentation depends on the site(s) of metastasis, number, and size of the smooth muscle tumors. Emergent presentations of BML are reviewed.

After All, It was Not Lung Cancer: When The Evidence is Misleading

2021 ◽  
Author(s):  
Joana Braga ◽  
Francesca Pereira ◽  
Cristiana Fernandes ◽  
Marinha Silva ◽  
Cristina Marques ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Presentation ◽  
Pulmonary Nodules ◽  
Rapid Diagnosis ◽  
Emission Tomography ◽  
Pleuritic Chest Pain ◽  
Surgical Specimen ◽  
Positron Emission ◽  
Malignant Lesions ◽  
Serious Disease

The aetiology of pulmonary nodules is varied, with malignant lesions being the most important and requiring rapid diagnosis and treatment. However, although clinical presentation and imaging may suggest a specific diagnosis, it should be kept in mind that some benign pathologies mimic more serious disease. A 50-year-old man presented with left pleuritic chest pain. A CT scan showed an ipsilateral pulmonary spiculated nodule. Pneumonia was assumed and the patient was started on antibiotic therapy. In the absence of improvement, positron emission tomography and a transthoracic aspiration biopsy were performed. Lung cancer was diagnosed and the patient underwent an upper lobectomy. However, examination of the surgical specimen showed no malignancy.

scholarly journals Benign Metastatic Leiomyoma Presenting as a Hemothorax

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Anna M. Ponea ◽  
Creticus P. Marak ◽  
Harmeen Goraya ◽  
Achuta K. Guddati
Keyword(s):  
Bone Marrow ◽  
Respiratory Failure ◽  
Hormonal Therapy ◽  
Skeletal Muscles ◽  
Pulmonary Nodules ◽  
Immunohistochemical Analysis ◽  
Lung Parenchyma ◽  
Molecular Profiling ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

Uterine leiomyomas have been reported to metastasize to various organs including the lungs, skeletal muscles, bone marrow, peritoneum, and heart. They may present with symptoms related to the metastases several years after hysterectomy. These tumors regress after menopause, and it is rare to detect active tumors in postmenopausal women. Despite their ability to metastasize, they are considered to be benign due to the lack of anaplasia. Pulmonary benign metastasizing leiomyoma is usually detected in the form of pulmonary nodules incidentally on imaging. Tissue biopsy of these nodules is required to identify them as benign metastasizing leiomyomas. Immunohistochemical analysis and molecular profiling may further help detect any malignant transformation in it. Untreated pulmonary benign metastasizing leiomyoma may result in the formation of cystic structures, destruction of lung parenchyma, and hemothorax and may cause respiratory failure. Surgical resection and hormonal therapy help prevent progression of this disease and provide an avenue for a cure.

scholarly journals After All, It was Not Lung Cancer: When The Evidence is Misleading

2021 ◽  
Author(s):  
Joana Braga ◽  
Francesca Pereira ◽  
Cristiana Fernandes ◽  
Marinha Silva ◽  
Cristina Marques ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Presentation ◽  
Pulmonary Nodules ◽  
Rapid Diagnosis ◽  
Emission Tomography ◽  
Pleuritic Chest Pain ◽  
Surgical Specimen ◽  
Positron Emission ◽  
Malignant Lesions ◽  
Serious Disease

The aetiology of pulmonary nodules is varied, with malignant lesions being the most important and requiring rapid diagnosis and treatment. However, although clinical presentation and imaging may suggest a specific diagnosis, it should be kept in mind that some benign pathologies mimic more serious disease. A 50-year-old man presented with left pleuritic chest pain. A CT scan showed an ipsilateral pulmonary spiculated nodule. Pneumonia was assumed and the patient was started on antibiotic therapy. In the absence of improvement, positron emission tomography and a transthoracic aspiration biopsy were performed. Lung cancer was diagnosed and the patient underwent an upper lobectomy. However, examination of the surgical specimen showed no malignancy.

Perivascular Leiomyomatosis: A Unique Case Report

2018 ◽  
Vol 26 (7) ◽  
pp. 676-679 ◽  
Author(s):  
Scott Wolfe ◽  
James Sullivan ◽  
Leonard Kahn
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Outer Surface ◽  
Muscle Layer ◽  
Growth Patterns ◽  
Unique Case ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma ◽  
Multiple Nodules

There are 3 histologically benign smooth muscle neoplasms that have unusual growth patterns. These include intravascular leiomyomatosis, benign metastasizing leiomyoma, and leiomyomatosis peritonealis desseminata. We report a unique case of perivascular leiomyomatosis. The tumor showed multiple nodules of benign smooth muscle with some of the nodules closely associated with the periphery of the medial muscle layer of venous channels. All the neoplastic nodules were located on the outer surface of venous channels, thus precluding a diagnosis of intravascular leiomyomatosis. To the best of our knowledge, this is the first documentation of such an entity.

Pulmonary Benign Metastasizing Leiomyoma, a Rare Cause of Pulmonary Nodules

2016 ◽  
Vol 52 (4) ◽  
pp. 226-227
Author(s):  
Patricia Pérez-Ferrer ◽  
Eusebi Chiner ◽  
José Norberto Sancho-Chust ◽  
Mar Arlandis
Keyword(s):  
Pulmonary Nodules ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

scholarly journals Benign Metastatic Leiomyoma: Unusual Heart Location

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Elaouni S ◽  
◽  
Jebli S ◽  
Sassi S ◽  
Bernoussi Z ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Progesterone Receptors ◽  
Smooth Muscle Tumor ◽  
Cardiac Metastasis ◽  
Cardiac Tumors ◽  
Clinical Settings ◽  
Benign Metastasizing Leiomyoma ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Cardiac smooth muscle tumors are rare; three different clinical settings for these tumors have been reported, including benign metastasizing leiomyoma from the uterus, primary cardiac leiomyoma and leiomyosarcoma, and intravenous cardiac extension of pelvic leiomyoma, which is the most common. We present a case of a 56-year-old woman with a benign metastasizing leiomyoma to the heart without associated pulmonary localization 15 years after endoscopic vaginal myomectomy of polymyomatous uterus. Immunohistochemical stains for H-Caldesmon, Desmin, and estrogen, progesterone receptors were positive, indicating a smooth muscle tumor of uterine origin. To our knowledge, this is only the fifth reported case of benign metastasizing leiomyoma to the heart with histological proof and the first case of earlier onset cardiac metastasis without pulmonary metastasis localization. It illustrates that benign metastasizing leiomyoma should be included in the differential diagnosis of cardiac tumors in patients with a history of surgery uterine leiomyoma perfectly benign.

scholarly journals Benign Metastasizing Leiomyoma to the Lung and Spine: A Case Report and Literature Review

2019 ◽  
Vol 12 (1) ◽  
pp. 218-223 ◽  
Author(s):  
Emily Barber ◽  
Ann Eapen ◽  
Rita Mehta ◽  
Erin Lin ◽  
Karen Lane ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Postmenopausal Woman ◽  
Hormonal Treatment ◽  
Current Management ◽  
Benign Metastasizing Leiomyoma ◽  
Clinical Challenge ◽  
Management Plans ◽  
Metastasizing Leiomyoma ◽  
Molecular Patterns

Benign metastasizing leiomyomas (BML) represent a rare phenomenon consisting of the extra-uterine spread of smooth muscle cells with similar histological, immunological, and molecular patterns to those of benign uterine leiomyomas. They are considered benign based off their low mitotic activity, lack of anaplasia or necrosis, and limited vascularization. This condition represents an interesting diagnostic and treatment challenge based on their rarity and indolent nature. Our case represents a unique finding of BML in the thoracic spine in a postmenopausal woman many years after hysterectomy and partial oophorectomy. There are currently no standard guidelines for treatment of BML, given the rare nature of this condition, with most patients treated with a combination of surgical resection and radiotherapy, followed by hormonal treatment and radiological surveillance serving as the primary backbone of current management plans. Given that these patients present a unique clinical challenge in terms of diagnosis and management, it is important to delineate and further examine these rare entities.

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