scholarly journals Benign Metastasizing Leiomyoma: A Rare Type of Lung Metastases—Two Case Reports and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Rokana Taftaf ◽  
Sandra Starnes ◽  
Jiang Wang ◽  
Ralph Shipley ◽  
Tariq Namad ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Progesterone Receptors ◽  
Pulmonary Nodules ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Benign Metastasizing Leiomyoma ◽  
Ct Guided ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rare disease that usually occurs in women of reproductive age. They typically have history of uterine leiomyoma treated with hysterectomy. BML can metastasize to distant organs, with the lung being the most common organ. We report two patients who presented with benign metastasizing leiomyoma to the lung. Our first case was a fifty-two-year-old female who presented with multiple lung masses, with a past medical history of uterine leiomyoma who underwent hysterectomy 17 years ago. A CT-guided biopsy showed benign appearing spindle cells and pathology confirmed her diagnosis with additional positive estrogen/progesterone receptor stains. Our second case was a fifty-six-year-old female who presented with multiple cavitary pulmonary nodules. She subsequently underwent a video-assisted thoracoscopic surgery (VATS) with wedge resection of one of the nodules. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining strongly positive for estrogen/progesterone receptors. Benign metastasizing leiomyoma is a rare condition which may affect women of reproductive age. This should be considered in the differential in patients who present with multiple pulmonary nodules, especially with a history of uterine leiomyoma. Additional stains, such as estrogen/progesterone receptors, may need to be done to confirm the diagnosis.

scholarly journals Benign Metastatic Leiomyoma: Unusual Heart Location

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Elaouni S ◽  
◽  
Jebli S ◽  
Sassi S ◽  
Bernoussi Z ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Progesterone Receptors ◽  
Smooth Muscle Tumor ◽  
Cardiac Metastasis ◽  
Cardiac Tumors ◽  
Clinical Settings ◽  
Benign Metastasizing Leiomyoma ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Cardiac smooth muscle tumors are rare; three different clinical settings for these tumors have been reported, including benign metastasizing leiomyoma from the uterus, primary cardiac leiomyoma and leiomyosarcoma, and intravenous cardiac extension of pelvic leiomyoma, which is the most common. We present a case of a 56-year-old woman with a benign metastasizing leiomyoma to the heart without associated pulmonary localization 15 years after endoscopic vaginal myomectomy of polymyomatous uterus. Immunohistochemical stains for H-Caldesmon, Desmin, and estrogen, progesterone receptors were positive, indicating a smooth muscle tumor of uterine origin. To our knowledge, this is only the fifth reported case of benign metastasizing leiomyoma to the heart with histological proof and the first case of earlier onset cardiac metastasis without pulmonary metastasis localization. It illustrates that benign metastasizing leiomyoma should be included in the differential diagnosis of cardiac tumors in patients with a history of surgery uterine leiomyoma perfectly benign.

scholarly journals Multisystemic Benign Metastasizing Leiomyoma: An Unusual Condition with an Atypical Clinical Presentation

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Fernando Matos ◽  
Cristina Santiago ◽  
Duarte Silva
Keyword(s):  
The Body ◽  
Reproductive Age ◽  
Low Back ◽  
Soft Tissue Density ◽  
Benign Metastasizing Leiomyoma ◽  
Essential Condition ◽  
Atypical Clinical Presentation ◽  
History Of ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rarely found entity with few documented cases in the literature, usually occurring in women of reproductive age with a history of myomectomy or hysterectomy. The leiomyomas can metastasize to several organs, the lungs being the most commonly affected. We report a case of a 40-year-old female patient who presented at our institution with low back pain. She underwent a lumbar MR that revealed the presence of an expansive and compressive mass in the body of L4. This mass was biopsied, corresponding to a metastasizing leiomyoma with no malignant characteristics. Subsequently, a CT examination showed several soft tissue density round masses in both lungs, but the most striking feature was a 12 cm mass located in the left iliac crest. There was asymmetrical uterus enlargement, caused by the presence of several leiomyomas. Since the lesions were estrogen and progesterone positive, hormone suppression consisting of oophorectomy followed by anastrozole was the chosen treatment. No signs of progression were observed at the 6-month follow-up. This case is one of the very few that occurred in a woman with no previous uterine intervention, adding further evidence that surgery is not an essential condition for this entity to develop.

Clinical case the combination of uterine leiomyoma and pregnancy

2017 ◽  
pp. 65-68
Author(s):  
M.V. Makarenko ◽  
◽  
D.O. Hovsieiev ◽  
L.I. Martynova ◽  
K.V. Mesropyan ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
Uterine Leiomyoma ◽  
Clinical Case ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Choice Of Treatment ◽  
Fetal Malformations ◽  
History Of ◽  
Medical Examinations

This article describes the clinical case mix uterine fibroids and pregnancy 11–12 weeks diagnosed with trisomy 21 in the fetus hrosomi. The history of the study of uterine fibroids, current views on the pathogenesis, etiology and treatment. Highlighted describes the practical value that indicates the need for regular preventive medical examinations of women of reproductive age, the importance of planning pregnancy and choice of treatment for fetal malformations and tumors of the uterus. Key words: uterine fibroids, pregnancy, surgery.

Oestrogen and Progesterone Receptor Concentrations in Leiomyoma and Normal Myometrium

1987 ◽  
Vol 24 (3) ◽  
pp. 263-267 ◽  
Author(s):  
O Sadan ◽  
B Van Iddekinge ◽  
C J Van Gelderen ◽  
N Savage ◽  
P J Becker ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Progesterone Receptor ◽  
Uterine Leiomyoma ◽  
Progesterone Receptors ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Receptor Level ◽  
First Report ◽  
Steroid Dependence ◽  
High Concentrations

The content of cytoplasmic 17β oestradiol and progesterone receptors in human uterine leiomyoma and normal myometrium in the Negroid population was determined. Eighteen women of reproductive age, at various stages of the menstrual cycle, were included in the study. The serum oestrogen and progesterone concentrations were also measured. This is the first report in the literature in which oestrogen and progesterone receptors in leiomyoma are significantly higher than in normal myometrium ( P=0·0002). The steroid dependence of the growth of leiomyomas may be related to the steroid receptor level. The presence of persistently high concentrations of oestrogen and progesterone receptors in leiomyoma should be helpful in the treatment of this benign tumour.

scholarly journals Cystic Endometriosis in a Huge Degenerated Subserous Leiomyoma Mimicking Bilateral Multicystic Endometriomas in an Infertile Woman with Diminished Ovarian Reserve: A Rare Endometriotic Implantation

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Safak Hatirnaz ◽  
Sabri Colak ◽  
Abdulkadir Reis
Keyword(s):  
Uterine Leiomyoma ◽  
Cystic Mass ◽  
Reproductive Age ◽  
Infertile Woman ◽  
Cystic Degeneration ◽  
Women Of Reproductive Age ◽  
Diagnostic Challenge ◽  
Peritoneal Disease ◽  
Pubmed Search ◽  
History Of

Uterine leiomyomas are the most common pelvic tumor in women. Leiomyoma can show atypical locations and degenerations and may not be easily differentiated from adnexal masses. Uterine leiomyoma can undergo cystic degeneration and is said to be found in 4% of all types of degenerations. The commonest type of degeneration is hyaline seen in 60% of patients. Usually uterine leiomyoma does not present as clinical and radiological diagnostic challenge. However, when leiomyoma undergoes massive cystic degeneration they may become clinical and radiological diagnostic dilemmas. The MRI showed a huge cystic mass protruding up to the pelvis not differentiated from bilateral endometriomas and accompanying subserous myomas. Surgery revealed that the mass is not bilateral endometriomas but a huge pedunculated leiomyoma with cystic degeneration and cystic endometriosis. Endometriosis is a troubling gynecologic condition occurring in 10% to 15% of women of reproductive age and is associated with fertility problems. As a peritoneal disease, the locations of endometriotic lesions are predominantly the ovaries (96.4%), followed by the soft tissue (2.8%), gastrointestinal tract (0.3%), and urinary tract (0.2%) and other rare locations. The presented case is multiple sized cystic endometriosis (endometriomas) located in a huge pedunculated subserous leiomyoma in an infertile woman having a history of laparoscopic bilateral endometrioma surgery.Conclusion. To our knowledge, this is the first reported case for endometriotic cysts (endometriomas) located in a huge cystic degenerated leiomyoma. PubMed search revealed no report concerning endometriotic implantation in the leiomyomas.

scholarly journals Incidental Benign Metastasizing Leiomyoma in a Patient with Bone Sarcoma: A Case Report

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Zanndor Jacob del Real-Romo ◽  
Carlos Montero-Cantú ◽  
Oscar Villegas-Cabello ◽  
José Antonio Díaz-Elizondo ◽  
Danae Reyes-Salas ◽  
...  
Keyword(s):  
Ct Scan ◽  
Pulmonary Nodules ◽  
Rare Condition ◽  
Bone Sarcoma ◽  
Conservative Surgery ◽  
Left Knee ◽  
Pathology Report ◽  
Benign Metastasizing Leiomyoma ◽  
History Of ◽  
Metastasizing Leiomyoma

Background. The benign metastasizing leiomyoma is an exceptionally rare entity; it presents with ectopic leiomyoma nodules with a benign pattern. Symptoms vary according to the anatomic location. The diagnosis is histopathological, usually in patients with history of hysterectomy.Case Presentation. A 36-year-old female with 2-month history of left knee pain was diagnosed with bone fibrosarcoma. A CT scan showed pulmonary nodules. The patient started neoadjuvant chemotherapy. Conservative surgery of pelvic limb was achieved. A new CT scan reported pulmonary nodules that remained in relation to the previous CT. A nodule resection by thoracotomy and TOB (transoperative biopsy) was performed. The final pathology report described benign proliferative lesions consistent with benign metastatic leiomyoma.Conclusions. Benign metastatic leiomyoma is a rare condition presenting with uterine and extrauterine nodules most commonly in the lung. The diagnosis is histopathological. The surgical procedure must be reserved for selected patients.

Evaluation of concomitant gynecological pathology in group of patients of reproductive age with tumors and tumor formations

2020 ◽  
pp. 10-14
Author(s):  
N. V. Spiridonova ◽  
A. A. Demura ◽  
V. Yu. Schukin
Keyword(s):  
Diagnostic Errors ◽  
Ovarian Tumors ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Predisposing Factor ◽  
Ovarian Tumours ◽  
Preoperative Diagnostic ◽  
Neoplastic Process ◽  
History Of ◽  
The Moment

According to modern literature, the frequency of preoperative diagnostic errors for tumour-like formations is 30.9–45.6%, for malignant ovarian tumors is 25.0–51.0%. The complexity of this situation is asymptomatic tumor in the ovaries and failure to identify a neoplastic process, which is especially important for young women, as well as ease the transition of tumors from one category to another (evolution of the tumor) and the source of the aggressive behavior of the tumor. The purpose of our study was to evaluate the history of concomitant gynecological pathology in a group of patients of reproductive age with ovarian tumors and tumoroid formations, as a predisposing factor for the development of neoplastic process in the ovaries. In our work, we collected and processed complaints and data of obstetric and gynecological anamnesis of 168 patients of reproductive age (18–40 years), operated on the basis of the Department of oncogynecology for tumors and ovarian tumours in the Samara Regional Clinical Oncology Dispensary from 2012 to 2015. We can conclude that since the prognosis of neoplastic process in the ovaries is generally good with timely detection and this disease occurs mainly in women of reproductive age, doctors need to know that when assessing the parity and the presence of gynecological pathology at the moment or in anamnesis, it is not possible to identify alarming risk factors for the development of cancer in the ovaries.

scholarly journals Clinical and chest CT presentations from 27 patients with COVID-19 pneumonia in Mogadishu, Somalia: a descriptive study

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Yahye Garad Mohamed ◽  
Mohamed Farah Yusuf Mohamud ◽  
M. Sabri Medişoğlu ◽  
Ihsan Yavuz Atamaca ◽  
Ibrahim Hussein Ali
Keyword(s):  
Sore Throat ◽  
Pulmonary Nodules ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
First Case ◽  
Abnormal Chest ◽  
Lower Lung ◽  
History Of ◽  
Normal Chest ◽  
Bilateral Lung

Abstract Background Coronavirus disease 2019 (COVID-19) is an acute viral pneumonia that had recently been found in humans. The first case was discovered in Wuhan, Hubei province, China, in December 2019. In this article, we aimed to demonstrate the clinical and radiological characteristics of COVID-19 patients in Somalia from 20 March 2020 to 20 April 2020. Results Twenty-seven patients that had a positive RT-PCR test between 20 March 2020 and 20 April 2020 were retrospectively observed. This study included 19 (70.4%) males and 8 (29.6%) females, and the mean age and range were 43 years (SD ± 14.0) and 27–70 years, respectively. The majority (59.3%) of COVID-19-infected patients had no obvious history of exposure to infected patients. The participants of our study mostly presented with dry cough 24 (88.9%) patients, fever 19 (70.4%), myalgia 18 (66.6%), and sore throat 16 (59.3%). Twenty-five of 27 patients had abnormal chest CT, while 2 (7.4%) patients had normal chest CT. The most common patterns of abnormality seen on chest CT in patients with COVID-19 were ground-glass opacity (GGO) 74.1%, crazy paving pattern 18.5%, consolidation 14.8%, and mixed GCO 11.1%. Also, the most common predominant lesion distributions were bilateral lung involvement (88.9%), peripheral distribution (77.8%), and lower lung predominance (63%). Particularly, lung cavitation, discrete pulmonary nodules, pleural effusion, and underlying pulmonary fibrosis or emphysema had not been observed. Conclusion Dry cough, fever, myalgia, and sore throat were the most clinical presentations. GGO, crazy paving pattern, patchy consolidation, and mixed GCO were the typical chest CT manifestations.

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