Norsesquiterpenes from the Roots of White Kwao Krua (Pueraria mirifica)

2014 ◽  
Vol 57 (4) ◽  
pp. 347-352 ◽  
Author(s):  
Jung-Hwa Kwon ◽  
Jin-Gyeong Cho ◽  
Hee-Jung Park ◽  
Gyu-Won Huh ◽  
Myun-Ho Bang ◽  
...  
2013 ◽  
Vol 62 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Nobuo Yagi ◽  
Hiroshi Nakahashi ◽  
Tomohiro Kobayashi ◽  
Mitsuo Miyazawa

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3442
Author(s):  
Yaowared Chulikhit ◽  
Wichitsak Sukhano ◽  
Supawadee Daodee ◽  
Waraporn Putalun ◽  
Rakvajee Wongpradit ◽  
...  

The effects of the phytoestrogen-enriched plant Pueraria mirifica (PM) extract on ovari-ectomy (OVX)-induced cognitive impairment and hippocampal oxidative stress in mice were investigated. Daily treatment with PM and 17β-estradiol (E2) significantly elevated cognitive behavior as evaluated by using the Y maze test, the novel object recognition test (NORT), and the Morris water maze test (MWM), attenuated atrophic changes in the uterus and decreased serum 17β-estradiol levels. The treatments significantly ameliorated ovariectomy-induced oxidative stress in the hippocampus and serum by a decrease in malondialdehyde (MDA), an enhancement of superoxide dismutase, and catalase activity, including significantly down-regulated expression of IL-1β, IL-6 and TNF-α proinflammatory cytokines, while up-regulating expression of PI3K. The present results suggest that PM extract suppresses oxidative brain damage and dysfunctions in the hippocampal antioxidant system, including the neuroinflammatory system in OVX animals, thereby preventing OVX-induced cognitive impairment. The present results indicate that PM exerts beneficial effects on cognitive deficits for which menopause/ovariectomy have been implicated as risk factors.


2021 ◽  
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Asami Kashiwa ◽  
Yukio Hosaka ◽  
Kazuyoshi Takahashi ◽  
Seiko Ohno ◽  
Yuko Wada ◽  
...  
Keyword(s):  

Toxins ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 275 ◽  
Author(s):  
Anna Kakehashi ◽  
Midori Yoshida ◽  
Yoshiyuki Tago ◽  
Naomi Ishii ◽  
Takahiro Okuno ◽  
...  

Nature ◽  
1960 ◽  
Vol 188 (4753) ◽  
pp. 774-777 ◽  
Author(s):  
JAMES C. CAIN
Keyword(s):  

2007 ◽  
Vol 53 (5) ◽  
pp. 995-1005 ◽  
Author(s):  
Sukanya JAROENPORN ◽  
Suchinda MALAIVIJITNOND ◽  
Kingkaew WATTANASIRMKIT ◽  
Gen WATANABE ◽  
Kazuyoshi TAYA ◽  
...  

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