Mirœstrol: An Œstrogen from the Plant Pueraria Mirifica

Nature ◽  
1960 ◽  
Vol 188 (4753) ◽  
pp. 774-777 ◽  
Author(s):  
JAMES C. CAIN
Keyword(s):  
Pueraria Mirifica

scholarly journals Effects of Pueraria candollei var mirifica (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3442
Author(s):  
Yaowared Chulikhit ◽  
Wichitsak Sukhano ◽  
Supawadee Daodee ◽  
Waraporn Putalun ◽  
Rakvajee Wongpradit ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Morris Water Maze Test ◽  
Object Recognition Test ◽  
Pueraria Mirifica ◽  
Beneficial Effects ◽  
Maze Test ◽  
Y Maze ◽  
Tnf Α ◽  
17Β Estradiol

The effects of the phytoestrogen-enriched plant Pueraria mirifica (PM) extract on ovari-ectomy (OVX)-induced cognitive impairment and hippocampal oxidative stress in mice were investigated. Daily treatment with PM and 17β-estradiol (E2) significantly elevated cognitive behavior as evaluated by using the Y maze test, the novel object recognition test (NORT), and the Morris water maze test (MWM), attenuated atrophic changes in the uterus and decreased serum 17β-estradiol levels. The treatments significantly ameliorated ovariectomy-induced oxidative stress in the hippocampus and serum by a decrease in malondialdehyde (MDA), an enhancement of superoxide dismutase, and catalase activity, including significantly down-regulated expression of IL-1β, IL-6 and TNF-α proinflammatory cytokines, while up-regulating expression of PI3K. The present results suggest that PM extract suppresses oxidative brain damage and dysfunctions in the hippocampal antioxidant system, including the neuroinflammatory system in OVX animals, thereby preventing OVX-induced cognitive impairment. The present results indicate that PM exerts beneficial effects on cognitive deficits for which menopause/ovariectomy have been implicated as risk factors.

scholarly journals Pueraria mirifica , an estrogenic tropical herb, unveiled the severity of Type 1 LQTS caused by KCNQ1 ‐T587M

2021 ◽  
Author(s):  
Asami Kashiwa ◽  
Yukio Hosaka ◽  
Kazuyoshi Takahashi ◽  
Seiko Ohno ◽  
Yuko Wada ◽  
...  
Keyword(s):  
Pueraria Mirifica

scholarly journals Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats

Toxins ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 275 ◽  
Author(s):  
Anna Kakehashi ◽  
Midori Yoshida ◽  
Yoshiyuki Tago ◽  
Naomi Ishii ◽  
Takahiro Okuno ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Carcinogenesis ◽  
Pueraria Mirifica ◽  
Estrogenic Effects ◽  
Donryu Rats

scholarly journals Assessment of Fertility and Reproductive Toxicity in Adult Female Mice after Long-Term Exposure to Pueraria mirifica Herb

2007 ◽  
Vol 53 (5) ◽  
pp. 995-1005 ◽  
Author(s):  
Sukanya JAROENPORN ◽  
Suchinda MALAIVIJITNOND ◽  
Kingkaew WATTANASIRMKIT ◽  
Gen WATANABE ◽  
Kazuyoshi TAYA ◽  
...  
Keyword(s):  
Adult Female ◽  
Reproductive Toxicity ◽  
Pueraria Mirifica ◽  
Female Mice

Coumestans from the roots of pueraria mirifica

1988 ◽  
Vol 43 (1-2) ◽  
pp. 5-10 ◽  
Author(s):  
John L. Ingham ◽  
Satoshi Tahara ◽  
Stanley Z. Dziedzic
Keyword(s):  
Methanolic Extract ◽  
Pueraria Mirifica

Three isoflavonoids obtained from a methanolic extract of Pueraria mirifica roots have been identified as 3,9-dihydroxy-8-methoxy-7-(3,3-dimethylallyl)-coumestan (mirificoumestan), 3,9-dihydroxy- 8-methoxy-7-(3-hydroxy-3-methylbutyl)-coumestan (mirificoumestan hydrate), and 3,9- dihydroxy-8-methoxy-7-(2,3-dihydroxy-3-methylbutyl)-coumestan (mirificoumestan glycol). These new coumestans co-occur with coumestrol (3,9-dihydroxycoumestan), a compound already found in P. mirifica roots

Norsesquiterpenes from the Roots of White Kwao Krua (Pueraria mirifica)

2014 ◽  
Vol 57 (4) ◽  
pp. 347-352 ◽  
Author(s):  
Jung-Hwa Kwon ◽  
Jin-Gyeong Cho ◽  
Hee-Jung Park ◽  
Gyu-Won Huh ◽  
Myun-Ho Bang ◽  
...  
Keyword(s):  
Pueraria Mirifica ◽  
White Kwao Krua

scholarly journals An overview of the phytoestrogen effect on vaginal health and dyspareunia in peri- and post-menopausal women

2019 ◽  
Vol 25 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Fatemeh R Dizavandi ◽  
Masoumeh Ghazanfarpour ◽  
Nasibeh Roozbeh ◽  
Leila Kargarfard ◽  
Talat Khadivzadeh ◽  
...  
Keyword(s):  
Similar Efficacy ◽  
Cochrane Central Register ◽  
Vaginal Atrophy ◽  
Pueraria Mirifica ◽  
Menopausal Women ◽  
Significant Difference ◽  
Vaginal Health ◽  
Post Menopausal ◽  
Intermediate Cells ◽  
Conjugated Estrogen

Objective The aim of this overview was to evaluate the effectiveness of phytoestrogens on vaginal health and dyspareunia in peri- and post-menopausal women. Material and methods Three databases including MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials were from inception to August 2017. Result Two systematic reviews and 11 RCTs were included in the overview. According to the findings, isoflavones increased the maturation value and attenuated the vaginal atrophy in the post-menopausal women. Topical isoflavones had beneficial effects on the vaginal atrophy. Similar efficacy was found in Pueraria mirifica and conjugated estrogen cream on dryness ( p = 0.277), soreness ( p = 0.124) and irritation ( p = 0.469), as well as discharge ( p = 0.225) and dyspareunia ( p = 0.089). However, the conjugated estrogen cream was more effective compared to Pueraria mirifica ( p > 0.005) regarding maturation index improvement. Comparison of fennel 5% vaginal cream and placebo gel showed significant difference in superficial cells ( p < 0.01), parabasal cells ( p < 0.01) and intermediate cells ( p < 0.01), whereas no difference was found between the oral fennel and placebo in terms of superficial, parabasal and intermediate cells as well as Maturation value. Administration of 80 mg red clover oil had a significant effect on superficial ( p < 0.005), intermediate ( p < 0.005) and parabasal and vaginal dryness ( p < 0.005) compared to the placebo. Flaxseed had also a trivial effect on maturation value. Genistein had a more prominent effect on the genital score. The severity of dyspareunia decreased by 27%. Conclusion Phytoestrogens have various effects based on administration route and type on the vaginal atrophy.

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