scholarly journals Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

10.3791/54776 ◽  
2016 ◽  
Author(s):  
Serhat Gündüz ◽  
Tanja Savić ◽  
Đorđe Toljić ◽  
Goran Angelovski
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging

Characterization of hepatic lesions (≤30mm) with liver-specific contrast agents: A comparison between ultrasound and magnetic resonance imaging

2013 ◽  
Vol 82 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Masanori Takahashi ◽  
Hitoshi Maruyama ◽  
Taro Shimada ◽  
Hidehiro Kamezaki ◽  
Tadashi Sekimoto ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Hepatic Lesions

Spurious Hypocalcemia After Omniscan- or OptiMARK-Enhanced Magnetic Resonance Imaging: An Algorithm for Minimizing a False-Positive Laboratory Value

2004 ◽  
Vol 128 (10) ◽  
pp. 1151-1156
Author(s):  
Jane Emerson ◽  
Gerald Kost
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Calcium Level ◽  
Gadopentetate Dimeglumine ◽  
Total Calcium ◽  
Resonance Imaging ◽  
Contrast Enhanced ◽  
Calcium Measurement

Abstract Contrast-enhanced magnetic resonance imaging has become a routine diagnostic imaging procedure. Reports in the literature document that 2 of the 4 available gadolinium-based magnetic resonance imaging contrast agents, gadodiamide (Omniscan) and gadoversetamide (OptiMARK), are less stable and readily undergo dechelation. In vitro, this dechelation can result in interference with the most common laboratory methods used to measure total plasma or serum calcium. The result of total calcium measurement soon after contrast-enhanced magnetic resonance imaging with these interfering contrast agents is a spurious lowering of the total calcium level. This low calcium measurement may result in a value consistent with hypocalcemia and can persist in patients with renal insufficiency and in patients receiving higher doses of contrast agent. Alternatively, a clinically significant elevated calcium level may be overlooked because of the artificially lowered value. Two of the available gadolinium-based contrast agents, gadoteridol (ProHance) and gadopentetate dimeglumine (Magnevist), have not been to shown to interfere with total calcium measurement. A clinical practice algorithm for the laboratorian, the radiologist, and the clinician is presented to minimize the occurrence and consequences of a spuriously lowered total calcium level due to Omniscan- or OptiMARK-enhanced magnetic resonance imaging.

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