Polymeric contrast agents for magnetic resonance imaging: synthesis and characterization of gadolinium diethylenetriaminepentaacetic acid conjugated to polysaccharides

1990 ◽  
Vol 1 (6) ◽  
pp. 365-374 ◽  
Author(s):  
Frances E. Armitage ◽  
David E. Richardson ◽  
King C. P. Li
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Synthesis And Characterization ◽  
Diethylenetriaminepentaacetic Acid ◽  
Resonance Imaging

scholarly journals Contrast Enhancement of the Brain by Folate-Conjugated Gadolinium–Diethylenetriaminepentaacetic Acid–Human Serum Albumin Nanoparticles by Magnetic Resonance Imaging

2012 ◽  
Vol 11 (4) ◽  
pp. 7290.2011.00047 ◽  
Author(s):  
Huedayi Korkusuz ◽  
Karsten Ulbrich ◽  
Verena Bihrer ◽  
Katerina Welzel ◽  
Valery Chernikov ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agents ◽  
Diethylenetriaminepentaacetic Acid ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
The Brain ◽  
Signal Intensities

Different from regular small molecule contrast agents, nanoparticle-based contrast agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties. We evaluated the tissue distribution of polymeric nanoparticles (NPs) prepared from human serum albumin (HSA), loaded with gadolinium–diethylenetriaminepentaacetic acid (Gd-DTPA) (Gd-HSA-NP), and coated with folic acid (FA) (Gd-HSA-NP-FA) in mice by magnetic resonance imaging (MRI). FA increases the affinity of the Gd-HSA-NP to FA receptor–expressing cells. Clinical 3 T MRI was used to evaluate the signal intensities in the different organs of mice injected with Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-FA. Signal intensities were measured and standardized by calculating the signal to noise ratios. In general, the NP-based contrast agents provided stronger contrasting than Gd-DTPA. Gd-HSA-NP-FA provided a significant contrast enhancement (CE) in the brain ( p = .0032), whereas Gd-DTPA or Gd-HSA-NP did not. All studied MRI contrast agents showed significant CE in the blood, kidney, and liver ( p < .05). Gd-HSA-NP-FA elicited significantly higher CE in the blood than Gd-HSA-NP ( p = .0069); Gd-HSA-NP and Gd-HSA-NP-FA did not show CE in skeletal muscle and gallbladder; Gd-HSA-NP, but not Gd-HSA-NP-FA, showed CE in the cardiac muscle. Gd-HSA-NP-FA has potential as an MRI contrast agent in the brain.

Multivalent Contrast Agents Based on Gadolinium−Diethylenetriaminepentaacetic Acid-Terminated Poly(propylene imine) Dendrimers for Magnetic Resonance Imaging

2004 ◽  
Vol 37 (9) ◽  
pp. 3084-3091 ◽  
Author(s):  
Sander Langereis ◽  
Quido G. de Lussanet ◽  
Marcel H. P. van Genderen ◽  
Walter H. Backes ◽  
E. W. Meijer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Diethylenetriaminepentaacetic Acid ◽  
Resonance Imaging ◽  
Poly Propylene

Characterization of hepatic lesions (≤30mm) with liver-specific contrast agents: A comparison between ultrasound and magnetic resonance imaging

2013 ◽  
Vol 82 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Masanori Takahashi ◽  
Hitoshi Maruyama ◽  
Taro Shimada ◽  
Hidehiro Kamezaki ◽  
Tadashi Sekimoto ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Hepatic Lesions
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