In vitro and ex vivo relaxometric properties of ethylene glycol coated gadolinium oxide nanoparticles for potential use as contrast agents in magnetic resonance imaging

2020 ◽  
Vol 128 (3) ◽  
pp. 034903
Author(s):  
Anamika Chaturvedi ◽  
Pranjali Pranjali ◽  
Mukesh Kumar Meher ◽  
Ritu Raj ◽  
Madhuri Basak ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Ethylene Glycol ◽  
Contrast Agents ◽  
Ex Vivo ◽  
Gadolinium Oxide ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Potential Use

Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

2021 ◽  
Author(s):  
Anton Popov ◽  
Maxim Artemovich Abakumov ◽  
Irina Savintseva ◽  
Artem Ermakov ◽  
Nelly Popova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Selective Cytotoxicity ◽  
Magnetic Resonance Imaging Mri

Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

2D Gadolinium Oxide Nanoplates as T 1 Magnetic Resonance Imaging Contrast Agents

2021 ◽  
pp. 2001780
Author(s):  
Gary Stinnett ◽  
Nasim Taheri ◽  
Jake Villanova ◽  
Arash Bohloul ◽  
Xiaoting Guo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Gadolinium Oxide ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Contrast

scholarly journals Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging

Nanomaterials ◽  
2016 ◽  
Vol 6 (6) ◽  
pp. 109 ◽  
Author(s):  
Alejandro Cabrera-García ◽  
Alejandro Vidal-Moya ◽  
Ángela Bernabeu ◽  
Jesús Pacheco-Torres ◽  
Elisa Checa-Chavarria ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

scholarly journals Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Inorganics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 28 ◽  
Author(s):  
Irene Fernández-Barahona ◽  
María Muñoz-Hernando ◽  
Jesus Ruiz-Cabello ◽  
Fernando Herranz ◽  
Juan Pellico
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Positive Contrast ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
The Past ◽  
T1 Contrast

Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers have also exploited their application as positive (T1) contrast agents to overcome the limitation of traditional Gd3+ contrast agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over the size, morphology and surface of the particles. In this review, we summarise the reported T1 iron oxide nanoparticles and critically revise their properties, synthetic protocols and application, not only in MRI but also in multimodal imaging. In addition, we briefly summarise the most important nanoparticulate Gd and Mn agents to evaluate whether T1 iron oxide nanoparticles can reach Gd/Mn contrast capabilities.

scholarly journals Concurrent Dual Contrast for Cellular Magnetic Resonance Imaging Using Gadolinium Oxide and Iron Oxide Nanoparticles

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Yasir Loai ◽  
Tameshwar Ganesh ◽  
Hai-Ling Margaret Cheng
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Negative Contrast ◽  
7 Tesla ◽  
Cell Populations ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mixed Cell ◽  
Fe Oxide

Rationale and Objectives. Concurrent visualization of differential targets in cellular and molecular imaging is valuable for resolving processes spatially and temporally, as in monitoring different cell subtypes. The purpose of this study was to demonstrate concurrent, dual (positive and negative) contrast visualization on magnetic resonance imaging (MRI) of two colocalized cell populations labeled with Gadolinium “Gd” oxide and iron “Fe” oxide nanoparticles. Materials and Methods. Human aortic endothelial cells (EC) and smooth muscle cells (SMC) were labeled with various concentrations of Gd oxide and Fe oxide, respectively. MRI on single- or mixed-cell samples was performed at 7 tesla. Proper cell phenotype expressions, cell uptake of contrast agents, and the effect of labeling on cell viability and proliferation were also determined. Results. Both contrast agents were efficiently taken up by cells, with viability and proliferation largely unaffected. On MRI, the positive contrast associated with Gd oxide-labeled EC and negative contrast associated with Fe oxide-labeled SMC discriminated the presence of each cell type, whether it existed alone or colocalized in a mixed-cell sample. Conclusion. It is feasible to use Gd oxide and Fe oxide for dual contrast and concurrent discrimination of two colocalized cell populations on MRI at 7 tesla.

Spurious Hypocalcemia After Omniscan- or OptiMARK-Enhanced Magnetic Resonance Imaging: An Algorithm for Minimizing a False-Positive Laboratory Value

2004 ◽  
Vol 128 (10) ◽  
pp. 1151-1156
Author(s):  
Jane Emerson ◽  
Gerald Kost
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Calcium Level ◽  
Gadopentetate Dimeglumine ◽  
Total Calcium ◽  
Resonance Imaging ◽  
Contrast Enhanced ◽  
Calcium Measurement

Abstract Contrast-enhanced magnetic resonance imaging has become a routine diagnostic imaging procedure. Reports in the literature document that 2 of the 4 available gadolinium-based magnetic resonance imaging contrast agents, gadodiamide (Omniscan) and gadoversetamide (OptiMARK), are less stable and readily undergo dechelation. In vitro, this dechelation can result in interference with the most common laboratory methods used to measure total plasma or serum calcium. The result of total calcium measurement soon after contrast-enhanced magnetic resonance imaging with these interfering contrast agents is a spurious lowering of the total calcium level. This low calcium measurement may result in a value consistent with hypocalcemia and can persist in patients with renal insufficiency and in patients receiving higher doses of contrast agent. Alternatively, a clinically significant elevated calcium level may be overlooked because of the artificially lowered value. Two of the available gadolinium-based contrast agents, gadoteridol (ProHance) and gadopentetate dimeglumine (Magnevist), have not been to shown to interfere with total calcium measurement. A clinical practice algorithm for the laboratorian, the radiologist, and the clinician is presented to minimize the occurrence and consequences of a spuriously lowered total calcium level due to Omniscan- or OptiMARK-enhanced magnetic resonance imaging.

Sign in / Sign up

Export Citation Format

Share Document