scholarly journals Chemoenzymatic synthesis and biological evaluation of enantiomerically enriched 1-(β-hydroxypropyl)imidazolium- and triazolium-based ionic liquids

2013 ◽  
Vol 9 ◽  
pp. 516-525 ◽  
Author(s):  
Paweł Borowiecki ◽  
Małgorzata Milner-Krawczyk ◽  
Jan Plenkiewicz
Keyword(s):  
Ionic Liquids ◽  
Vinyl Acetate ◽  
Propylene Oxide ◽  
Ring Opening ◽  
Biological Evaluation ◽  
Optically Active ◽  
Chemoenzymatic Synthesis ◽  
Alkyl Bromides ◽  
Wide Range ◽  
Synthesis And Biological Evaluation

Racemic 1-(β-hydroxypropyl)azoles were prepared by solvent-free direct regioselective ring opening of 1,2-propylene oxide with imidazole or 1,2,4-triazole. Lipase-catalyzed transesterification of alcohols with vinyl acetate resulted in kinetic enantiomers resolution. Separated (S)-enantiomers of (+)-1-(1H-imidazol-1-yl)propan-2-ol and (+)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol were quaternized with alkyl bromides or iodides, yielding novel optically active ionic liquids. Racemic salts were tested against a wide range of microorganisms.

ChemInform Abstract: Synthesis and Biological Evaluation of Optically Active Conjugated γ- and δ-Lactone Derivatives.

ChemInform ◽  
2013 ◽  
Vol 44 (4) ◽  
pp. no-no
Author(s):  
Melis Sardan ◽  
Serdar Sezer ◽  
Aslihan Guenel ◽  
Mahinur Akkaya ◽  
Cihangir Tanyeli
Keyword(s):  
Biological Evaluation ◽  
Optically Active ◽  
Synthesis And Biological Evaluation

Novel quinoline-derived mTOR inhibitors with remarkable enzymatic and cellular activities: design, synthesis and biological evaluation

MedChemComm ◽  
2016 ◽  
Vol 7 (2) ◽  
pp. 297-310 ◽  
Author(s):  
Xiao-Dong Ma ◽  
Ni Qiu ◽  
Bo Yang ◽  
Qiao-Jun He ◽  
Yong-Zhou Hu
Keyword(s):  
Ring Opening ◽  
Mtor Inhibitors ◽  
Biological Evaluation ◽  
Cellular Activity ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Compound 24, obtained via a ring-opening strategy, exhibited both attractive mTOR potency and superior cellular activity to initial lead 9.

Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-β-lactams Through Stereo- and Regioselective Epoxide Ring Opening.

ChemInform ◽  
2007 ◽  
Vol 38 (12) ◽  
Author(s):  
Fides Benfatti ◽  
Giuliana Cardillo ◽  
Luca Gentilucci ◽  
Rossana Perciaccante ◽  
Alessandra Tolomelli ◽  
...  
Keyword(s):  
Ring Opening ◽  
Biological Evaluation ◽  
Epoxide Ring ◽  
Epoxide Ring Opening ◽  
Synthesis And Biological Evaluation

Novel deoxy-selenylconduritols: chemoenzymatic synthesis and biological evaluation

2009 ◽  
Vol 20 (23) ◽  
pp. 2673-2676 ◽  
Author(s):  
Ana Bellomo ◽  
Ana Bertucci ◽  
Hélio Stefani ◽  
Álvaro Vázquez ◽  
David Gonzalez
Keyword(s):  
Biological Evaluation ◽  
Chemoenzymatic Synthesis ◽  
Synthesis And Biological Evaluation

Short Regioselective Chemoenzymatic Synthesis and Biological Evaluation of 1-O-Acyl-2-O-(β-D-sulfoquinovopyranosyl)-sn-glycerols

2009 ◽  
Vol 2009 (34) ◽  
pp. 6019-6026 ◽  
Author(s):  
Milind Dangate ◽  
Laura Franchini ◽  
Fiamma Ronchetti ◽  
Takanari Arai ◽  
Akira Iida ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Chemoenzymatic Synthesis ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of the Novel Antitumor Agent Aurone Derivatives

2013 ◽  
Vol 781-784 ◽  
pp. 1235-1239
Author(s):  
Qian Nan Guo ◽  
Lei Lv ◽  
Yao Zhou ◽  
Peng Yu ◽  
Yuou Teng
Keyword(s):  
Biological Activities ◽  
Antitumor Agent ◽  
Biological Evaluation ◽  
The Novel ◽  
Pharmacological Activities ◽  
Design Synthesis ◽  
H Nmr ◽  
Wide Range ◽  
Inhibitory Activities ◽  
Synthesis And Biological Evaluation

Aurones belong to a class of heterocyclic flavonoids which contains a benzofuran element associated with a benzylidene linked in position 2. Aurones possess a wide range of pharmacological activities and biological activities, such as antitumor, antifungal, phytoalexin and so on. A novel series of 2-ayl-yl (5-methacrylate) aurone analogues were synthesized in six steps with the overall yield of 11%-13% and characterized by 1H NMR. Among the key intermediates and target compounds, 2-(2-furan-ylmethylene)-5-methacrylate-benzofuran-3(2H)-one (7a) and 2-(2-thienyl-ylmethylene)-5-methacrylate-benzofuran-3(2H)-one (7b) have never been reported before. Primary biological activities evaluation showed that 7a exhibited good inhibitory activities against K562 with an IC50 of 2.18 μM and against HepG2 with an IC50 of 3.95μM.

ChemInform Abstract: Synthesis and Biological Evaluation of Optically Active Ki16425.

ChemInform ◽  
2012 ◽  
Vol 43 (44) ◽  
pp. no-no
Author(s):  
Takanao Sato ◽  
Kenji Sugimoto ◽  
Asuka Inoue ◽  
Shinichi Okudaira ◽  
Junken Aoki ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Optically Active ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of optically active Ki16425

2012 ◽  
Vol 22 (13) ◽  
pp. 4323-4326 ◽  
Author(s):  
Takanao Sato ◽  
Kenji Sugimoto ◽  
Asuka Inoue ◽  
Shinichi Okudaira ◽  
Junken Aoki ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Optically Active ◽  
Synthesis And Biological Evaluation
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