Chemoenzymatic synthesis and biological evaluation of 2- and 3-hydroxypyridine derivatives against Leishmania mexicana

2012 ◽  
Vol 20 (15) ◽  
pp. 4614-4624 ◽  
Author(s):  
Guadalupe García Liñares ◽  
Gonzalo Parraud ◽  
Carlos Labriola ◽  
Alicia Baldessari
Keyword(s):  
Biological Evaluation ◽  
Chemoenzymatic Synthesis ◽  
Leishmania Mexicana ◽  
Synthesis And Biological Evaluation

scholarly journals Chemoenzymatic synthesis and biological evaluation of enantiomerically enriched 1-(β-hydroxypropyl)imidazolium- and triazolium-based ionic liquids

2013 ◽  
Vol 9 ◽  
pp. 516-525 ◽  
Author(s):  
Paweł Borowiecki ◽  
Małgorzata Milner-Krawczyk ◽  
Jan Plenkiewicz
Keyword(s):  
Ionic Liquids ◽  
Vinyl Acetate ◽  
Propylene Oxide ◽  
Ring Opening ◽  
Biological Evaluation ◽  
Optically Active ◽  
Chemoenzymatic Synthesis ◽  
Alkyl Bromides ◽  
Wide Range ◽  
Synthesis And Biological Evaluation

Racemic 1-(β-hydroxypropyl)azoles were prepared by solvent-free direct regioselective ring opening of 1,2-propylene oxide with imidazole or 1,2,4-triazole. Lipase-catalyzed transesterification of alcohols with vinyl acetate resulted in kinetic enantiomers resolution. Separated (S)-enantiomers of (+)-1-(1H-imidazol-1-yl)propan-2-ol and (+)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol were quaternized with alkyl bromides or iodides, yielding novel optically active ionic liquids. Racemic salts were tested against a wide range of microorganisms.

Novel deoxy-selenylconduritols: chemoenzymatic synthesis and biological evaluation

2009 ◽  
Vol 20 (23) ◽  
pp. 2673-2676 ◽  
Author(s):  
Ana Bellomo ◽  
Ana Bertucci ◽  
Hélio Stefani ◽  
Álvaro Vázquez ◽  
David Gonzalez
Keyword(s):  
Biological Evaluation ◽  
Chemoenzymatic Synthesis ◽  
Synthesis And Biological Evaluation

Short Regioselective Chemoenzymatic Synthesis and Biological Evaluation of 1-O-Acyl-2-O-(β-D-sulfoquinovopyranosyl)-sn-glycerols

2009 ◽  
Vol 2009 (34) ◽  
pp. 6019-6026 ◽  
Author(s):  
Milind Dangate ◽  
Laura Franchini ◽  
Fiamma Ronchetti ◽  
Takanari Arai ◽  
Akira Iida ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Chemoenzymatic Synthesis ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of newer 1,3,4-oxadiazoles incorporated with benzothiazepine and benzodiazepine moieties

2017 ◽  
Vol 72 (3-4) ◽  
pp. 133-146 ◽  
Author(s):  
Patel Navin ◽  
Patel Sarvil ◽  
Purohit Amit ◽  
Patel Divyesh ◽  
Rajani Dhansukh ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Giardia Lamblia ◽  
Antitubercular Activity ◽  
Biological Evaluation ◽  
Leishmania Mexicana ◽  
Aspergillus Clavatus ◽  
Biological Screening ◽  
Synthesis And Biological Evaluation

Abstract A series of thiazepines and diazepines having 1,3,4-oxadiazole moiety were synthesized, and they were analyzed for their in vitro antimicrobial activity against several bacteria (Staphylococcus aureus, Staphylococcus pyogenes, Escherichia coli, and Pseudomonas aeruginosa) and fungi (Candida albicans, Aspergillus niger, and Aspergillus Clavatus) and protozoa (Entamoeba histolytica, Giardia lamblia, Trypanosoma cruzi and Leishmania mexicana). Few of the selected compounds were tested for their antitubercular activity. However, it was noticed that the potency of final analogs against each strain placed reliance on the type of substituent present on aryl ring of oxadiazole as well as presence of thiophene, pyridine, and furan at benzothiazepines and benzodiazepines. The biological screening identified that some of the compounds were found to possess good antimicrobial and antitubercular (62.5–100 μg/mL of MIC) activity.

ChemInform Abstract: Chemoenzymatic Synthesis and Biological Evaluation of (-)-Conduramine C-4.

ChemInform ◽  
2008 ◽  
Vol 39 (11) ◽  
Author(s):  
Ana Bellomo ◽  
Cecilia Giacomini ◽  
Beatriz Brena ◽  
Gustavo Seoane ◽  
David Gonzalez
Keyword(s):  
Biological Evaluation ◽  
Chemoenzymatic Synthesis ◽  
Synthesis And Biological Evaluation

Chemoenzymatic Synthesis and Biological Evaluation of (−)‐Conduramine C‐4

2007 ◽  
Vol 37 (20) ◽  
pp. 3509-3518 ◽  
Author(s):  
Ana Bellomo ◽  
Cecilia Giacomini ◽  
Beatriz Brena ◽  
Gustavo Seoane ◽  
David Gonzalez
Keyword(s):  
Biological Evaluation ◽  
Chemoenzymatic Synthesis ◽  
Synthesis And Biological Evaluation

Chemoenzymatic synthesis and biological evaluation of C-3 carbamate analogues of 1α,25-dihydroxyvitamin D3

2004 ◽  
Vol 12 (20) ◽  
pp. 5443-5451 ◽  
Author(s):  
Vicente Gotor-Fernández ◽  
Susana Fernández ◽  
Miguel Ferrero ◽  
Vicente Gotor ◽  
Roger Bouillon ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Chemoenzymatic Synthesis ◽  
Dihydroxyvitamin D3 ◽  
Synthesis And Biological Evaluation

Convergent chemoenzymatic synthesis and biological evaluation of a heparan sulfate proteoglycan syndecan-1 mimetic

2021 ◽  
Vol 57 (27) ◽  
pp. 3407-3410
Author(s):  
Jia Gao ◽  
Yongmei Xu ◽  
Jian Liu ◽  
Xuefei Huang
Keyword(s):  
Heparan Sulfate ◽  
Biological Evaluation ◽  
Heparan Sulfate Proteoglycan ◽  
Chemoenzymatic Synthesis ◽  
Sulfate Proteoglycan ◽  
Biological Studies ◽  
Synthesis Strategy ◽  
Synthesis And Biological Evaluation

A new convergent chemoenzymatic synthesis strategy has been established to efficiently synthesize a mimetic of structurally well-defined heparan sulfate proteoglycan syndecan-1 glyco-polypeptide at a milligram scale to enable biological studies.

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