Novel quinoline-derived mTOR inhibitors with remarkable enzymatic and cellular activities: design, synthesis and biological evaluation

Xiao-Dong Ma; Ni Qiu; Bo Yang; Qiao-Jun He; Yong-Zhou Hu

doi:10.1039/c5md00401b

Novel quinoline-derived mTOR inhibitors with remarkable enzymatic and cellular activities: design, synthesis and biological evaluation

MedChemComm ◽

10.1039/c5md00401b ◽

2016 ◽

Vol 7 (2) ◽

pp. 297-310 ◽

Cited By ~ 5

Author(s):

Xiao-Dong Ma ◽

Ni Qiu ◽

Bo Yang ◽

Qiao-Jun He ◽

Yong-Zhou Hu

Keyword(s):

Ring Opening ◽

Mtor Inhibitors ◽

Biological Evaluation ◽

Cellular Activity ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Compound 24, obtained via a ring-opening strategy, exhibited both attractive mTOR potency and superior cellular activity to initial lead 9.

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Design, synthesis and biological evaluation of novel 3 H -imidazole [4,5- b ] pyridine derivatives as selective mTOR inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2017.06.010 ◽

2017 ◽

Vol 27 (15) ◽

pp. 3395-3398 ◽

Cited By ~ 6

Author(s):

Lingzhi Zhang ◽

Tantan Bu ◽

Xiaobo Bao ◽

Tingting Liang ◽

Yiran Ge ◽

...

Keyword(s):

Mtor Inhibitors ◽

Biological Evaluation ◽

Pyridine Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of substituted 2-(thiophen-2-yl)-1,3,5-triazine derivatives as potential dual PI3Kα/mTOR inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.103525 ◽

2020 ◽

Vol 95 ◽

pp. 103525

Author(s):

Binliang Zhang ◽

Qian Zhang ◽

Zhen Xiao ◽

Xin Sun ◽

Zunhua Yang ◽

...

Keyword(s):

Mtor Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Triazine Derivatives ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of imidazo[1,2- b ]pyridazine derivatives as mTOR inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.02.015 ◽

2017 ◽

Vol 129 ◽

pp. 135-150 ◽

Cited By ~ 11

Author(s):

Beibei Mao ◽

Shanyun Gao ◽

Yiran Weng ◽

Liangren Zhang ◽

Lihe Zhang

Keyword(s):

Mtor Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Pyridazine Derivatives ◽

Synthesis And Biological Evaluation

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Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS): The design, synthesis and biological evaluation

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.11.003 ◽

2015 ◽

Vol 23 (24) ◽

pp. 7585-7596 ◽

Cited By ~ 11

Author(s):

Xiaodong Ma ◽

Xiaoqing Lv ◽

Ni Qiu ◽

Bo Yang ◽

Qiaojun He ◽

...

Keyword(s):

Hydrogen Bonding ◽

Molecular Hydrogen ◽

Mtor Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of some Chalcone Derivatives as Potential Pancreatic Lipase Inhibitors

10.3390/ecsoc-17-b024 ◽

2013 ◽

Author(s):

Dao Tran

Keyword(s):

Pancreatic Lipase ◽

Biological Evaluation ◽

Design Synthesis ◽

Chalcone Derivatives ◽

Pancreatic Lipase Inhibitors ◽

Synthesis And Biological Evaluation

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Faculty Opinions recommendation of Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726271231.793520213 ◽

2016 ◽

Author(s):

Miles Congreve ◽

Mark Pickworth

Keyword(s):

G Protein ◽

Biological Evaluation ◽

Receptor Kinase ◽

G Protein Coupled Receptor ◽

Design Synthesis ◽

G Protein Coupled ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

Letters in Drug Design & Discovery ◽

10.2174/157018012799079842 ◽

2012 ◽

Vol 9 (2) ◽

pp. 140-152 ◽

Cited By ~ 1

Author(s):

Romeo Romagnoli ◽

Pier Giovanni Baraldi ◽

Olga Cruz-Lopez ◽

Maria Kimatrai Salvador ◽

Delia Preti ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Hybrid Molecules ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

Letters in Drug Design & Discovery ◽

10.2174/15701808113109990024 ◽

2013 ◽

Vol 10 (10) ◽

pp. 935-941

Author(s):

Yan Tang ◽

Zhewei Tu ◽

Jing Sun ◽

Xiong Zhu ◽

Kun Liu ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Derivatives Of

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Design, Synthesis and Biological Evaluation of Some Oxadiazole Derivatives as Novel Amide-Based Inhibitors of Soluble Epoxide Hydrolase

Letters in Drug Design & Discovery ◽

10.2174/1570180811666140220005530 ◽

2014 ◽

Vol 11 (6) ◽

pp. 721-730 ◽

Cited By ~ 8

Author(s):

Elham Zavareh ◽

Mahdi Hedayati ◽

Laleh Rad ◽

Azin Kiani ◽

Soraya Shahhosseini ◽

...

Keyword(s):

Epoxide Hydrolase ◽

Soluble Epoxide Hydrolase ◽

Biological Evaluation ◽

Design Synthesis ◽

Oxadiazole Derivatives ◽

Synthesis And Biological Evaluation

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Rational Design, Synthesis and Biological Evaluation of Novel Derivatives Based on in vivo Metabolism of Natural Product β-elemene

Letters in Drug Design & Discovery ◽

10.2174/1570180814666171108093021 ◽

2018 ◽

Vol 15 (8) ◽

pp. 905-912 ◽

Cited By ~ 1

Author(s):

Renren Bai ◽

Xiaokang Jie ◽

Eric Salgado ◽

Jian Sun ◽

Yao Zhu ◽

...

Keyword(s):

Natural Product ◽

Rational Design ◽

Biological Evaluation ◽

In Vivo Metabolism ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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