Correlation between cognitive functions and syndromes of traditional Chinese medicine in vascular cognitive impairment

2011 ◽  
Vol 9 (10) ◽  
pp. 1075-1082 ◽  
Author(s):  
J Shi
Author(s):  
Rumjanceva Sof'Ja ◽  
Silina Ekaterina ◽  
Stupin Victor ◽  
Orlova Alexandra ◽  
Silin Serjej ◽  
...  

QJM ◽  
2019 ◽  
Vol 112 (6) ◽  
pp. 437-442 ◽  
Author(s):  
C -C Shih ◽  
C -C Yeh ◽  
J -L Yang ◽  
H -L Lane ◽  
C -J Huang ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Xinhua Zhou ◽  
Guozhen Cui ◽  
Hisa Hui Ling Tseng ◽  
Simon Ming-Yuen Lee ◽  
George Pak Heng Leung ◽  
...  

The prevalence of cognitive impairment and dementia caused by cerebrovascular disease is likely to increase with the global aging population. Vascular contributions to cognitive impairment and dementia (VCID) is a wide spectrum term used to include a diverse heterogeneous group of cognitive syndromes with vascular factors regardless of the cause of pathogenesis. VCID ranges from mild cognitive impairment to full-blown dementia with vascular dementia (VaD) as the most severe stage. It is further complexed by the coexistence of other forms of dementia such as Alzheimer’s disease (AD). Recent researches in the functions of the neurovascular unit (NVU) suggest that dysfunction of the NVU might be the cause of primary vascular events in the brain that leads to further neurodegeneration. In this review, we have briefly summarized various forms of VCID. There is currently no standard therapy for VCID or dementia. Given the fact that Traditional Chinese Medicine (TCM) has gained popularity worldwide, we also reviewed recent scientific and clinical findings on various antidementia TCM for the treatment of VCID, including Salvia miltiorrhiza, Huperzia serrata, Ligusticum chuanxiong, Ginkgo biloba, Panax ginseng, and also TCM formula Sailuotong capsule (SLT) and Fufangdanshen tablets (FFDS).


2020 ◽  
Vol 48 (03) ◽  
pp. 487-511
Author(s):  
Hui Pei ◽  
Lina Ma ◽  
Yu Cao ◽  
Feixue Wang ◽  
Zehui Li ◽  
...  

Cognitive impairment (CI) refers to the dysfunction of memory, language, visual space, execution, calculation, understanding, and judgment in one or more aspects. With global aging, CI will become prevalent worldwide. At present, there is no effective cure for CI. However, Nobel laureate Tu Youyou’s research on artemisinin has inspired Chinese researchers to focus on traditional Chinese herbs (TCHs) for the treatment of CI. Traditional Chinese Medicine (TCM) has led to a theory for an independent CI system. The pathogenesis of such impairment involves deficiency, phlegm, and stagnation and involves a range of organs, including the brain, kidneys, heart, liver, and spleen. Our current understanding of the etiology and pathogenesis of this condition has led to the realization that TCHs can improve cognitive dysfunction. Clinical research has shown that TCHs can improve the neuropsychological scale score of patients, the TCM symptom score, and the patient’s quality of life. Research has also suggested that TCHs can retard A[Formula: see text] deposits and tauopathy, regulate the metabolism of cholinergic neurotransmitters, and so on. However, due to their complexity, little is known of the safety and efficacy of TCHs in patients with CI. It is likely that we will be able to identify the precise mechanisms associated with the action of TCHs in such patients due to the integration of multiple technologies. This paper summarizes the pharmacokinetics, curative effect, and mechanisms of action of traditional Chinese herbs in order to provide a scientific basis for the improvement of cognitive dysfunction by TCHs.


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