scholarly journals Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Xinhua Zhou ◽  
Guozhen Cui ◽  
Hisa Hui Ling Tseng ◽  
Simon Ming-Yuen Lee ◽  
George Pak Heng Leung ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Wide Spectrum ◽  
Salvia Miltiorrhiza ◽  
Neurovascular Unit ◽  
Clinical Findings ◽  
Vascular Events ◽  
Severe Stage ◽  
The Brain

The prevalence of cognitive impairment and dementia caused by cerebrovascular disease is likely to increase with the global aging population. Vascular contributions to cognitive impairment and dementia (VCID) is a wide spectrum term used to include a diverse heterogeneous group of cognitive syndromes with vascular factors regardless of the cause of pathogenesis. VCID ranges from mild cognitive impairment to full-blown dementia with vascular dementia (VaD) as the most severe stage. It is further complexed by the coexistence of other forms of dementia such as Alzheimer’s disease (AD). Recent researches in the functions of the neurovascular unit (NVU) suggest that dysfunction of the NVU might be the cause of primary vascular events in the brain that leads to further neurodegeneration. In this review, we have briefly summarized various forms of VCID. There is currently no standard therapy for VCID or dementia. Given the fact that Traditional Chinese Medicine (TCM) has gained popularity worldwide, we also reviewed recent scientific and clinical findings on various antidementia TCM for the treatment of VCID, including Salvia miltiorrhiza, Huperzia serrata, Ligusticum chuanxiong, Ginkgo biloba, Panax ginseng, and also TCM formula Sailuotong capsule (SLT) and Fufangdanshen tablets (FFDS).

scholarly journals Discussion on the Mechanism of Action of High-frequency Drugs for Treating Heart Failure Based on Network Pharmacology

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Feifei Lei ◽  
Mingjun Zhao ◽  
Haifang Wang ◽  
Chao Pan ◽  
Xiaoya Shi
Keyword(s):  
Heart Failure ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Signaling Pathway ◽  
Salvia Miltiorrhiza ◽  
Network Pharmacology ◽  
Active Components ◽  
Radix Astragalus ◽  
Pharmacological Studies ◽  
Chinese Medicine Treatment

Objective: To explore the target and mechanism of Astragalus membranaceus, poria, salvia miltiorrhiza and semen leiocarpa in the treatment of heart failure by network pharmacology. Methods: The active components of traditional Chinese medicine and the target of heart failure were screened by multi-platform, and the standard gene was transformed by Uniprot. CytoCasp 3.6.1 was used to draw the network diagram of traditional Chinese medicine - component - target. Go and KEGG analysis were performed by Metascape. Results: A total of 36 predictive target sites of Radix Astragalus, Fuling poria, Salvia miltiorrhiza and Draba nemorosa were screened for treatment of heart failure, mainly involving nerve and factor pathways: ADRB2, ADRA1B and AChE. Cancer pathway: TP53, TNF; Pathways of inflammation: IL1B, PTSG2, PTSG1; Sex hormone pathway: ESR1, AR, PGR; Others: SCN5A, HIF1A, etc. The results of GO and KEGG enrichment suggested that the treatment of heart failure with the top four drugs involved cancer pathway, calcium signaling pathway, HIF-1 signaling pathway, and involved in blood circulation, cell proliferation and other processes. Conclusion: This study combines the pharmacological studies of Chinese medicine and western medicine to reveal the mechanism of multi-target and multi-channel regulation of body balance in Chinese medicine treatment.

scholarly journals Research Progress of Traditional Chinese Medicine in Prevention and Treatment of AIDS

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Guoqiang Yang ◽  
Lu Jiao
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Salvia Miltiorrhiza ◽  
Internal Resistance ◽  
Research Progress ◽  
Syndrome Differentiation ◽  
Therapeutic Effects ◽  
Hiv Replication ◽  
Deficiency Type ◽  
Tcm Syndrome

Objective: To review the research progress of using Chinese medicine ginseng to prevent and treat AIDS in China. Methods: Based on the method of TCM syndrome differentiation, Chinese medical researchers divided AIDS into four types: heat toxin stagnation type, Qi and blood deficiency type, stasis and internal resistance type, and Qi and Yin injury type. Results: The therapeutic effects of the compound preparation of traditional Chinese medicine were significant, such as Aikang capsule, Tangcao tablet, Wuweilingqi capsule, Aining granule, compound Sanhuang powder, etc. Astragalus, licorice, honeysuckle, Scutellaria, bupleurum, Salvia miltiorrhiza, Viola, Hedyotis diffusa and other 8 kinds of traditional Chinese medicine have been proved to have anti HIV effect. Conclusion: Among the 27 kinds of Chinese medicine ginseng, Andrographis paniculata, Viola, Arnebia, Arctium lappa, Sophora flavescens, honeysuckle, Guanzhong, Prunella, Coptis, Wolfberry, Wedelia and epimedium have been proved to have the effect of preventing HIV replication.

scholarly journals Reduced use of emergency care and hospitalization in patients with post-stroke cognitive impairment treated with traditional Chinese medicine

QJM ◽  
2019 ◽  
Vol 112 (6) ◽  
pp. 437-442 ◽  
Author(s):  
C -C Shih ◽  
C -C Yeh ◽  
J -L Yang ◽  
H -L Lane ◽  
C -J Huang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Emergency Care ◽  
Post Stroke
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