scholarly journals Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats

2019 ◽  
Vol Volume 15 ◽  
pp. 3167-3176 ◽  
Author(s):  
Qiong Wu ◽  
Yu Cao ◽  
Meixia Liu ◽  
Fang Liu ◽  
Adelheid H Brantner ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cholinergic Dysfunction

scholarly journals Reduced use of emergency care and hospitalization in patients with post-stroke cognitive impairment treated with traditional Chinese medicine

QJM ◽  
2019 ◽  
Vol 112 (6) ◽  
pp. 437-442 ◽  
Author(s):  
C -C Shih ◽  
C -C Yeh ◽  
J -L Yang ◽  
H -L Lane ◽  
C -J Huang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Emergency Care ◽  
Post Stroke

scholarly journals Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Xinhua Zhou ◽  
Guozhen Cui ◽  
Hisa Hui Ling Tseng ◽  
Simon Ming-Yuen Lee ◽  
George Pak Heng Leung ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Wide Spectrum ◽  
Salvia Miltiorrhiza ◽  
Neurovascular Unit ◽  
Clinical Findings ◽  
Vascular Events ◽  
Severe Stage ◽  
The Brain

The prevalence of cognitive impairment and dementia caused by cerebrovascular disease is likely to increase with the global aging population. Vascular contributions to cognitive impairment and dementia (VCID) is a wide spectrum term used to include a diverse heterogeneous group of cognitive syndromes with vascular factors regardless of the cause of pathogenesis. VCID ranges from mild cognitive impairment to full-blown dementia with vascular dementia (VaD) as the most severe stage. It is further complexed by the coexistence of other forms of dementia such as Alzheimer’s disease (AD). Recent researches in the functions of the neurovascular unit (NVU) suggest that dysfunction of the NVU might be the cause of primary vascular events in the brain that leads to further neurodegeneration. In this review, we have briefly summarized various forms of VCID. There is currently no standard therapy for VCID or dementia. Given the fact that Traditional Chinese Medicine (TCM) has gained popularity worldwide, we also reviewed recent scientific and clinical findings on various antidementia TCM for the treatment of VCID, including Salvia miltiorrhiza, Huperzia serrata, Ligusticum chuanxiong, Ginkgo biloba, Panax ginseng, and also TCM formula Sailuotong capsule (SLT) and Fufangdanshen tablets (FFDS).

The Protective Effects of Gardenia jasminoides (Fructus Gardenia) on Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity

2018 ◽  
Vol 46 (02) ◽  
pp. 389-405 ◽  
Author(s):  
Cai-Xia Zang ◽  
Xiu-Qi Bao ◽  
Lin Li ◽  
Han-Yu Yang ◽  
Lu Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Amyloid Β ◽  
Influential Factors ◽  
Chinese Herbs ◽  
Protective Effects ◽  
Disease Modifying Drugs ◽  
Gardenia Jasminoides ◽  
Cholinergic Dysfunction ◽  
Single Target

Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. Although the exact causes of AD have not yet been fully elucidated, cholinergic dysfunction, mitochondrial damage, oxidative stress and neuroinflammation have been recognized as influential factors. Current drugs that are designed to address only a single target are unable to mitigate or prevent the progression of this complicated disease, so new disease-modifying drugs are urgently needed. Chinese herbs with thousand years of effective usage might be a good source for potential drugs. Gardenia jasminoides J. Ellis (Fructus Gardenia) is a common traditional Chinese medicine with tranquilizing effects, which is an important component of widely-used traditional Chinese medicine for dementia. GJ-4 is crocin richments extracted from Gardenia jasminoides J. Ellis. In our study, we attempted to observe the effects of GJ-4 on learning and memory injury induced by amyloid-[Formula: see text] 25-35 (A[Formula: see text] injection in mice. Treatment with GJ-4 dose-dependently enhanced the memory and cognition ability of A[Formula: see text]-injected mice. Preliminary mechanistic studies revealed the protective effect of GJ-4 was related to its protection of neurons and cholinergic dysfunction. The mechanistic results also indicated that GJ-4 could enhance antioxidant capacity and attenuate neuroinflammation. Our results implied that GJ-4 might be a promising drug to improve cognitive and memory impairment, with multiple targets.

Traditional Chinese Medicine for Alzheimer’s Disease and Other Cognitive Impairment: A Review

2020 ◽  
Vol 48 (03) ◽  
pp. 487-511
Author(s):  
Hui Pei ◽  
Lina Ma ◽  
Yu Cao ◽  
Feixue Wang ◽  
Zehui Li ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cognitive Dysfunction ◽  
Visual Space ◽  
Nobel Laureate ◽  
Scientific Basis ◽  
Chinese Herbs ◽  
Quality Of Life Research

Cognitive impairment (CI) refers to the dysfunction of memory, language, visual space, execution, calculation, understanding, and judgment in one or more aspects. With global aging, CI will become prevalent worldwide. At present, there is no effective cure for CI. However, Nobel laureate Tu Youyou’s research on artemisinin has inspired Chinese researchers to focus on traditional Chinese herbs (TCHs) for the treatment of CI. Traditional Chinese Medicine (TCM) has led to a theory for an independent CI system. The pathogenesis of such impairment involves deficiency, phlegm, and stagnation and involves a range of organs, including the brain, kidneys, heart, liver, and spleen. Our current understanding of the etiology and pathogenesis of this condition has led to the realization that TCHs can improve cognitive dysfunction. Clinical research has shown that TCHs can improve the neuropsychological scale score of patients, the TCM symptom score, and the patient’s quality of life. Research has also suggested that TCHs can retard A[Formula: see text] deposits and tauopathy, regulate the metabolism of cholinergic neurotransmitters, and so on. However, due to their complexity, little is known of the safety and efficacy of TCHs in patients with CI. It is likely that we will be able to identify the precise mechanisms associated with the action of TCHs in such patients due to the integration of multiple technologies. This paper summarizes the pharmacokinetics, curative effect, and mechanisms of action of traditional Chinese herbs in order to provide a scientific basis for the improvement of cognitive dysfunction by TCHs.

scholarly journals Effects of Integrative Medicine on The Post-Stroke Cognitive Impairment (PSCI) Patients: A Study Protocol for A Randomized Multicentric Controlled Trial

2021 ◽  
Author(s):  
Xinyun Li ◽  
Kelin He ◽  
Lei Wu ◽  
Weijun Zheng ◽  
Kaitao Luo ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Integrative Medicine ◽  
Near Infrared ◽  
Controlled Trial ◽  
Depression Scale ◽  
Hamilton Depression Scale ◽  
Functional Near Infrared Spectroscopy ◽  
Post Stroke

Abstract Background Due to limitation of rehabilitation in cognitive impairment after stroke, as the main parts of traditional Chinese medicine, acupuncture and herbs have their advantage effect in clinical practice for post-stroke cognitive impairment (PSCI). Therefore, forming a standardized and propagable TCM project of PSCI becomes necessary. This trail will solve the above problem. Methods In total, 126 stroke patients will be recruited from the inpatient and outpatient departments of The Third Affiliated Hospital of Zhejiang Chinese Medical University (Hangzhou, China), Jiaxing Hospital of Traditional Chinese Medicine and Hangzhou Hospital of Traditional Chinese Medicine to participate in this study with randomization. All participants will continue to receive basic treatment and cognitive function regular training, while successive 12 weeks of acupuncture and herbs will be provided to patients assigned to the integrative medicine group. Montreal cognitive assessment (MOCA), mini-mental state examination, activity of daily living (ADL) score, hamilton depression scale (HAMD), functional near-infrared spectroscopy (fNIRS) and RESTing-state functional MRI (RS-fmri) will be used to measure the outcomes. Discussion This trial may provide high-quality RCT evidence regarding the clinical effectiveness and safety of acupuncture and herbs for PSCI patient. Trial registration: ClinicalTrials.gov (ID: NCT 04596072)

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