scholarly journals Sensitivity of a Label-Free Guided-Mode Resonant Optical Biosensor with Different Modes

Sensors ◽  
2012 ◽  
Vol 12 (7) ◽  
pp. 9791-9799 ◽  
Author(s):  
Qi Wang ◽  
Dawei Zhang ◽  
Huiyin Yang ◽  
Chunxian Tao ◽  
Yuanshen Huang ◽  
...  
Keyword(s):  
Optical Biosensor ◽  
Label Free ◽  
Guided Mode

scholarly journals Guided-mode Resonance Filter with Ultra-narrow Bandwidth over the Visible Frequencies for Label-free Optical Biosensor

2019 ◽  
Vol 3 (2) ◽  
pp. 406 ◽  
Author(s):  
Phuc Toan Dang ◽  
Khai Q. Le ◽  
Quang Minh Ngo ◽  
Hieu Pham Trung Nguyen ◽  
Truong Khang Nguyen
Keyword(s):  
Refractive Index ◽  
Spectral Response ◽  
Optical Filters ◽  
Optical Biosensor ◽  
Electromagnetic Spectrum ◽  
Label Free ◽  
High Background ◽  
Practical Applications ◽  
Guided Mode ◽  
Guided Mode Resonance

A practical guided-mode resonance filter operating in the visible band of the electromagnetic spectrum is numerically designed in this paper. The filter provides high background transmission (>90%) with almost perfect reflection at resonance wavelengths of 623 nm and 641 nm for TE and TM modes, respectively. Our filter is also characterized by its sensitivity to incident angles, polarizations, and a refractive index of the surrounding environment which are utilized in practical applications such as tunable optical filters, imaging or detection. We show that the resonant transmission spectral response can be used for highly sensitive, a potential label-free refractive index biosensor having sensitivities of 90 nm/RIU and 103 nm/RIU, and figure of merits of 1.93 and 2.13 for TM and TE polarizations, respectively.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Label-free optical biosensor based on a dual-core microstructured polymer optical fiber

Optik ◽  
2015 ◽  
Vol 126 (21) ◽  
pp. 2930-2933 ◽  
Author(s):  
Nai-Fei Ren ◽  
Bing Sun ◽  
Ming-Yang Chen
Keyword(s):  
Optical Fiber ◽  
Optical Biosensor ◽  
Label Free ◽  
Polymer Optical Fiber ◽  
Dual Core

An Optical Biosensor for Rapid and Label-Free Detection of Cells

2006 ◽  
Vol 128 (12) ◽  
pp. 3862-3863 ◽  
Author(s):  
Ghanashyam Acharya ◽  
Chun-Li Chang ◽  
Cagri Savran
Keyword(s):  
Optical Biosensor ◽  
Label Free ◽  
Label Free Detection

Real-time quantitation of viral replication and inhibitor potency using a label-free optical biosensor

2009 ◽  
Vol 29 (3-4) ◽  
pp. 195-201 ◽  
Author(s):  
Róisín M. Owens ◽  
ChangQing Wang ◽  
Juyoung A. You ◽  
Jantorn Jiambutr ◽  
Arron S.L. Xu ◽  
...  
Keyword(s):  
Viral Replication ◽  
Real Time ◽  
Optical Biosensor ◽  
Label Free

scholarly journals Optical multiplexed bioassays on photonic crystals for breast cancer biomarker detection

2021 ◽  
Vol 255 ◽  
pp. 13003
Author(s):  
Tommaso Pileri ◽  
Alberto Sinibaldi ◽  
Agostino Occhicone ◽  
Elena Giordani ◽  
Matteo Allegretti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Specific Interaction ◽  
Fluorescence Emission ◽  
Optical Biosensor ◽  
Cancer Biomarker ◽  
Time Development ◽  
Biomarker Detection ◽  
Label Free ◽  
One Dimensional ◽  
Protein Bovine Serum Albumin

An optical biosensor for proteomic breast cancer biomarker detection in complex media is presented. Bloch Surface Waves (BSW) excited onto one dimensional photonic crystal (1DPC) were used to probe the interaction of HER2 with three antibody species and an inert protein (Bovine Serum Albumin - BSA). The optical system combines Label-Free readings to track the bioassay real-time development and Fluorescence emission quantification to evaluate the level of specific interaction between the antigen and the antibodies. The results confirm a distinguishable level of affinity between the antibodies and the analyte according to their specificity even at low antibody surface density (about 1173 pg/mm2).

Label-free optical biosensor for real-time monitoring the cytotoxicity of xenobiotics: A proof of principle study on glyphosate

2018 ◽  
Vol 351 ◽  
pp. 80-89 ◽  
Author(s):  
Eniko Farkas ◽  
Andras Szekacs ◽  
Boglarka Kovacs ◽  
Marianna Olah ◽  
Robert Horvath ◽  
...  
Keyword(s):  
Real Time ◽  
Optical Biosensor ◽  
Label Free ◽  
Real Time Monitoring ◽  
Proof Of Principle

scholarly journals Aptamer Functionalized Lipid Multilayer Gratings for Label-Free Analyte Detection

Nanomaterials ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2433
Author(s):  
Plengchart Prommapan ◽  
Nermina Brljak ◽  
Troy W. Lowry ◽  
David Van Winkle ◽  
Steven Lenhert
Keyword(s):  
Lipid Composition ◽  
Optical Biosensor ◽  
Optical Signal ◽  
Dna Aptamer ◽  
Critical Parameters ◽  
Label Free ◽  
Scale Thickness ◽  
Label Free Detection ◽  
Analyte Detection ◽  
Micrometer Scale

Lipid multilayer gratings are promising optical biosensor elements that are capable of transducing analyte binding events into changes in an optical signal. Unlike solid state transducers, reagents related to molecular recognition and signal amplification can be incorporated into the lipid grating ink volume prior to fabrication. Here we describe a strategy for functionalizing lipid multilayer gratings with a DNA aptamer for the protein thrombin that allows label-free analyte detection. A double cholesterol-tagged, double-stranded DNA linker was used to attach the aptamer to the lipid gratings. This approach was found to be sufficient for binding fluorescently labeled thrombin to lipid multilayers with micrometer-scale thickness. In order to achieve label-free detection with the sub-100 nm-thick lipid multilayer grating lines, the binding affinity was improved by varying the lipid composition. A colorimetric image analysis of the light diffracted from the gratings using a color camera was then used to identify the grating nanostructures that lead to an optimal signal. Lipid composition and multilayer thickness were found to be critical parameters for the signal transduction from the aptamer functionalized lipid multilayer gratings.

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