Optimally designed narrowband guided-mode resonance transmittance filters for label-free optical biosensor

2020 ◽  
Author(s):  
Phuc Toan Dang ◽  
Ji-Hoon Lee
Keyword(s):  
Optical Biosensor ◽  
Label Free ◽  
Guided Mode ◽  
Guided Mode Resonance

scholarly journals Guided-mode Resonance Filter with Ultra-narrow Bandwidth over the Visible Frequencies for Label-free Optical Biosensor

2019 ◽  
Vol 3 (2) ◽  
pp. 406 ◽  
Author(s):  
Phuc Toan Dang ◽  
Khai Q. Le ◽  
Quang Minh Ngo ◽  
Hieu Pham Trung Nguyen ◽  
Truong Khang Nguyen
Keyword(s):  
Refractive Index ◽  
Spectral Response ◽  
Optical Filters ◽  
Optical Biosensor ◽  
Electromagnetic Spectrum ◽  
Label Free ◽  
High Background ◽  
Practical Applications ◽  
Guided Mode ◽  
Guided Mode Resonance

A practical guided-mode resonance filter operating in the visible band of the electromagnetic spectrum is numerically designed in this paper. The filter provides high background transmission (>90%) with almost perfect reflection at resonance wavelengths of 623 nm and 641 nm for TE and TM modes, respectively. Our filter is also characterized by its sensitivity to incident angles, polarizations, and a refractive index of the surrounding environment which are utilized in practical applications such as tunable optical filters, imaging or detection. We show that the resonant transmission spectral response can be used for highly sensitive, a potential label-free refractive index biosensor having sensitivities of 90 nm/RIU and 103 nm/RIU, and figure of merits of 1.93 and 2.13 for TM and TE polarizations, respectively.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

scholarly journals Quantification of Neuropeptide Y with Picomolar Sensitivity Enabled by Guided-Mode Resonance Biosensors

Sensors ◽  
2019 ◽  
Vol 20 (1) ◽  
pp. 126 ◽  
Author(s):  
Mohammad G. Abdallah ◽  
Joseph A. Buchanan-Vega ◽  
Kyu J. Lee ◽  
Brett R. Wenner ◽  
Jeffery W. Allen ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Near Infrared ◽  
Single Point ◽  
High Sensitivity ◽  
Quantitative Detection ◽  
Label Free ◽  
Sensor Surface ◽  
Detection Range ◽  
Guided Mode ◽  
Guided Mode Resonance

Assessing levels of neuropeptide Y (NPY) in the human body has many medical uses. Accordingly, we report the quantitative detection of NPY biomarkers applying guided-mode resonance (GMR) biosensor methodology. The label-free sensor operates in the near-infrared spectral region exhibiting distinctive resonance signatures. The interaction of NPY with bioselective molecules on the sensor surface causes spectral shifts that directly identify the binding event without additional processing. In the experiments described here, NPY antibodies are attached to the sensor surface to impart specificity during operation. For the low concentrations of NPY of interest, we apply a sandwich NPY assay in which the sensor-linked anti-NPY molecule binds with NPY that subsequently binds with anti-NPY to close the sandwich. The sandwich assay achieves a detection limit of ~0.1 pM NPY. The photonic sensor methodology applied here enables expeditious high-throughput data acquisition with high sensitivity and specificity. The entire bioreaction is recorded as a function of time, in contrast to label-based methods with single-point detection. The convenient methodology and results reported are significant, as the NPY detection range of 0.1–10 pM demonstrated is useful in important medical circumstances.

Sensitive metal layer-assisted guided-mode resonance SU8 nanopillar array for label-free optical biosensing

2016 ◽  
Vol 226 ◽  
pp. 204-210 ◽  
Author(s):  
Víctor Canalejas-Tejero ◽  
Ana López ◽  
Rafael Casquel ◽  
Miguel Holgado ◽  
Carlos Angulo Barrios
Keyword(s):  
Metal Layer ◽  
Label Free ◽  
Optical Biosensing ◽  
Guided Mode ◽  
Guided Mode Resonance

Integration of a guided-mode resonance filter with microposts for in-cell protein detection

The Analyst ◽  
2016 ◽  
Vol 141 (13) ◽  
pp. 4189-4195 ◽  
Author(s):  
Yi-Kai Tu ◽  
Meng-Zhe Tsai ◽  
I-Chin Lee ◽  
Hsin-Yun Hsu ◽  
Cheng-Sheng Huang
Keyword(s):  
Microfluidic Channel ◽  
Protein Detection ◽  
Cell Protein ◽  
Label Free ◽  
Guided Mode ◽  
Guided Mode Resonance

The integration of a label-free biosensor of a guided-mode resonance filter and a microfluidic channel with a micropost filter.

scholarly journals Sensitivity of a Label-Free Guided-Mode Resonant Optical Biosensor with Different Modes

Sensors ◽  
2012 ◽  
Vol 12 (7) ◽  
pp. 9791-9799 ◽  
Author(s):  
Qi Wang ◽  
Dawei Zhang ◽  
Huiyin Yang ◽  
Chunxian Tao ◽  
Yuanshen Huang ◽  
...  
Keyword(s):  
Optical Biosensor ◽  
Label Free ◽  
Guided Mode
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