Ultra low-cost optical biosensor based on guided mode resonance grating filter

2015 ◽  
Author(s):  
T. N. Chandrika ◽  
Hailu Dessalegn ◽  
T. Srinivas
Keyword(s):  
Low Cost ◽  
Optical Biosensor ◽  
Guided Mode ◽  
Guided Mode Resonance

scholarly journals Rapid and Highly Sensitive Detection of C-Reaction Protein Using Robust Self-Compensated Guided-Mode Resonance BioSensing System for Point-Of-Care Applications

Biosensors ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 523
Author(s):  
Chu-Tung Yeh ◽  
Devesh Barshilia ◽  
Chia-Jui Hsieh ◽  
Hsun-Yuan Li ◽  
Wen-Hsin Hsieh ◽  
...  
Keyword(s):  
Light Source ◽  
Transverse Electric ◽  
Point Of Care ◽  
Low Cost ◽  
Polarized Light ◽  
Transverse Magnetic ◽  
Sensitive Detection ◽  
Guided Mode ◽  
Guided Mode Resonance ◽  
Biosensing System

The rapid and sensitive detection of human C-reactive protein (CRP) in a point-of-care (POC) may be conducive to the early diagnosis of various diseases. Biosensors have emerged as a new technology for rapid and accurate detection of CRP for POC applications. Here, we propose a rapid and highly stable guided-mode resonance (GMR) optofluidic biosensing system based on intensity detection with self-compensation, which substantially reduces the instability caused by environmental factors for a long detection time. In addition, a low-cost LED serving as the light source and a photodetector are used for intensity detection and real-time biosensing, and the system compactness facilitates POC applications. Self-compensation relies on a polarizing beam splitter to separate the transverse-magnetic-polarized light and transverse-electric-polarized light from the light source. The transverse-electric-polarized light is used as a background signal for compensating noise, while the transverse-magnetic-polarized light is used as the light source for the GMR biosensor. After compensation, noise is drastically reduced, and both the stability and performance of the system are enhanced over a long period. Refractive index experiments revealed a resolution improvement by 181% when using the proposed system with compensation. In addition, the system was successfully applied to CRP detection, and an outstanding limit of detection of 1.95 × 10−8 g/mL was achieved, validating the proposed measurement system for biochemical reaction detection. The proposed GMR biosensing sensing system can provide a low-cost, compact, rapid, sensitive, and highly stable solution for a variety of point-of-care applications.

scholarly journals Resonant Subwavelength and Nano-Scale Grating Structures for Biosensing Application: A Comparative Study

Sensors ◽  
2021 ◽  
Vol 21 (13) ◽  
pp. 4523
Author(s):  
Mohammad Abutoama ◽  
Marwan Abuleil ◽  
Ibrahim Abdulhalim
Keyword(s):  
Comparative Study ◽  
Low Cost ◽  
Thin Metal Film ◽  
Phase Detection ◽  
Large Area ◽  
Nano Scale ◽  
Guided Mode ◽  
Flexible Designs ◽  
Extended Surface ◽  
Guided Mode Resonance

Resonant-based sensors are attractive optical structures due to the easy detection of shifts in the resonance location in response to variations in the analyte refractive index (RI) in comparison to non-resonant-based sensors. In particular, due to the rapid progress of nanostructures fabrication methods, the manufacturing of subwavelength and nano-scale gratings in a large area and at a low cost has become possible. A comparative study is presented involving analysis and experimental work on several subwavelength and nanograting structures, highlighting their nano-scale features’ high potential in biosensing applications, namely: (i) Thin dielectric grating on top of thin metal film (TDGTMF), which can support the excitation of extended surface plasmons (ESPs), guided mode resonance, or leaky mode; (ii) reflecting grating for conventional ESP resonance (ESPR) and cavity modes (CMs) excitation; (iii) thick dielectric resonant subwavelength grating exhibiting guided mode resonance (GMR) without a waveguide layer. Among the unique features, we highlight the following: (a) Self-referenced operation obtained using the TDGTMF geometry; (b) multimodal operation, including ESPR, CMs, and surface-enhanced spectroscopy using reflecting nanograting; (c) phase detection as a more sensitive approach in all cases, except the case of reflecting grating where phase detection is less sensitive than intensity or wavelength detection. Additionally, intensity and phase detection modes were experimentally demonstrated using off-the-shelf grating-based optical compact discs as a low-cost sensors available for use in a large area. Several flexible designs are proposed for sensing in the visible and infrared spectral ranges based on the mentioned geometries. In addition, enhanced penetration depth is also proposed for sensing large entities such as cells and bacteria using the TDGTMF geometry.

scholarly journals Guided-mode Resonance Filter with Ultra-narrow Bandwidth over the Visible Frequencies for Label-free Optical Biosensor

2019 ◽  
Vol 3 (2) ◽  
pp. 406 ◽  
Author(s):  
Phuc Toan Dang ◽  
Khai Q. Le ◽  
Quang Minh Ngo ◽  
Hieu Pham Trung Nguyen ◽  
Truong Khang Nguyen
Keyword(s):  
Refractive Index ◽  
Spectral Response ◽  
Optical Filters ◽  
Optical Biosensor ◽  
Electromagnetic Spectrum ◽  
Label Free ◽  
High Background ◽  
Practical Applications ◽  
Guided Mode ◽  
Guided Mode Resonance

A practical guided-mode resonance filter operating in the visible band of the electromagnetic spectrum is numerically designed in this paper. The filter provides high background transmission (>90%) with almost perfect reflection at resonance wavelengths of 623 nm and 641 nm for TE and TM modes, respectively. Our filter is also characterized by its sensitivity to incident angles, polarizations, and a refractive index of the surrounding environment which are utilized in practical applications such as tunable optical filters, imaging or detection. We show that the resonant transmission spectral response can be used for highly sensitive, a potential label-free refractive index biosensor having sensitivities of 90 nm/RIU and 103 nm/RIU, and figure of merits of 1.93 and 2.13 for TM and TE polarizations, respectively.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

Enhanced light trapping in Ge-on-Si-on-insulator photodetector by guided mode resonance effect

2018 ◽  
Vol 124 (5) ◽  
pp. 053101
Author(s):  
Zhi Liu ◽  
Jietao Liu ◽  
Buwen Cheng ◽  
Jun Zheng ◽  
Chuanbo Li ◽  
...  
Keyword(s):  
Light Trapping ◽  
Resonance Effect ◽  
Guided Mode ◽  
Guided Mode Resonance

scholarly journals A Compact Detection Platform Based on Gradient Guided-Mode Resonance for Colorimetric and Fluorescence Liquid Assay Detection

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2797
Author(s):  
Jing-Jhong Gao ◽  
Ching-Wei Chiu ◽  
Kuo-Hsing Wen ◽  
Cheng-Sheng Huang
Keyword(s):  
Limit Of Detection ◽  
Detection System ◽  
Fluorescence Emission ◽  
Assay Sensitivity ◽  
Detection Range ◽  
Current Form ◽  
Guided Mode ◽  
Spectral Detection ◽  
Guided Mode Resonance ◽  
Colorimetric Assays

This paper presents a compact spectral detection system for common fluorescent and colorimetric assays. This system includes a gradient grating period guided-mode resonance (GGP-GMR) filter and charge-coupled device. In its current form, the GGP-GMR filter, which has a size of less than 2.5 mm, can achieve a spectral detection range of 500–700 nm. Through the direct measurement of the fluorescence emission, the proposed system was demonstrated to detect both the peak wavelength and its corresponding intensity. One fluorescent assay (albumin) and two colorimetric assays (albumin and creatinine) were performed to demonstrate the practical application of the proposed system for quantifying common liquid assays. The results of our system exhibited suitable agreement with those of a commercial spectrometer in terms of the assay sensitivity and limit of detection (LOD). With the proposed system, the fluorescent albumin, colorimetric albumin, and colorimetric creatinine assays achieved LODs of 40.99 and 398 and 25.49 mg/L, respectively. For a wide selection of biomolecules in point-of-care applications, the spectral detection range achieved by the GGP-GMR filter can be further extended and the simple and compact optical path configuration can be integrated with a lab-on-a-chip system.

scholarly journals An integrated electro-optical biosensor system for rapid, low-cost detection of bacteria

2021 ◽  
Vol 239-240 ◽  
pp. 111523
Author(s):  
Dániel Petrovszki ◽  
Sándor Valkai ◽  
Evelin Gora ◽  
Martin Tanner ◽  
Anita Bányai ◽  
...  
Keyword(s):  
Low Cost ◽  
Optical Biosensor ◽  
Biosensor System
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