scholarly journals Challenges towards Targeted Drug Delivery in Cancer Nanomedicines

Processes ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1527
Author(s):  
Muhammad Nadeem Hafeez ◽  
Christian Celia ◽  
Vilma Petrikaite
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Tumor Tissue ◽  
Treatment Area ◽  
Specific Chemical ◽  
Nano Drug Delivery ◽  
Cancer Nanomedicine ◽  
Physical Stimuli ◽  
Personalized Cancer ◽  
Biopharmaceutical Properties

Despite cancer nanomedicine celebrates already thirty years since its introduction, together with the achievements and progress in cancer treatment area, it still undergoes serious disadvantages that must be addressed. Since the first observation that macromolecules tend to accumulate in tumor tissue due to fenestrated endothelial of vasculature, considered as the “royal gate” in drug delivery field, more than dozens of nanoformulations have been approved and introduced into the practice for cancer treatment. Lipid, polymeric, and hybrid nanocarriers are biocompatible nano-drug delivery systems (NDDs) having suitable physicochemical properties and modulate payload release in response to specific chemical or physical stimuli. Biopharmaceutical properties of NDDs and their efficacy in animal models and humans can significantly affect their impact and perspective in nanomedicine. One of the future directions could be focusing on personalized cancer treatment, considering the heterogeneity and complexity of each patient tumor tissue and the designing of multifunctional targeted NDDs combining synthetic nanomaterials and biological components, like cellular membranes, circulating proteins, RNAi/DNAi, which enforce the efficacy of NDDs and boost their therapeutic effect.

scholarly journals Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment

2021 ◽  
Vol 11 ◽  
Author(s):  
Marina Santiago Franco ◽  
Eliza Rocha Gomes ◽  
Marjorie Coimbra Roque ◽  
Mônica Cristina Oliveira
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Treatment ◽  
Basic Principle ◽  
Tumor Tissue ◽  
Lymphatic Drainage ◽  
Active Targeting ◽  
Tumor Site ◽  
Tumor Environment ◽  
Triggered Drug Release

Since more than 40 years liposomes have being extensively studied for their potential as carriers of anticancer drugs. The basic principle behind their use for cancer treatment consists on the idea that they can take advantage of the leaky vasculature and poor lymphatic drainage present at the tumor tissue, passively accumulating in this region. Aiming to further improve their efficacy, different strategies have been employed such as PEGlation, which enables longer circulation times, or the attachment of ligands to liposomal surface for active targeting of cancer cells. A great challenge for drug delivery to cancer treatment now, is the possibility to trigger release from nanosystems at the tumor site, providing efficacious levels of drug in the tumor. Different strategies have been proposed to exploit the outer and inner tumor environment for triggering drug release from liposomes and are the focus of this review.

Recent Progress of Nano-drug Delivery System for Liver Cancer Treatment

2018 ◽  
Vol 17 (14) ◽  
Author(s):  
Feilong Zhou ◽  
Fangfang Teng ◽  
Peizong Deng ◽  
Ning Meng ◽  
Zhimei Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Recent Progress ◽  
Nano Drug Delivery

scholarly journals Application of Nano-Drug Delivery System Based on Cascade Technology in Cancer Treatment

2021 ◽  
Vol 22 (11) ◽  
pp. 5698
Author(s):  
Ying Sun ◽  
Xiaoli Ma ◽  
Hao Hu
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Treatment Options ◽  
Cascade Reactions ◽  
Current Treatment ◽  
Traditional Treatment ◽  
Anticancer Efficacy ◽  
Good Therapeutic Effect ◽  
Specific Tumor ◽  
Nano Drug Delivery

In the current cancer treatment, various combination therapies have been widely used, such as photodynamic therapy (PDT) combined with chemokinetic therapy (CDT). However, due to the complexity of the tumor microenvironment (TME) and the limitations of treatment, the efficacy of current treatment options for some cancers is unsatisfactory. Nowadays, cascade technology has been used in cancer treatment and achieved good therapeutic effect. Cascade technology based on nanotechnology can trigger cascade reactions under specific tumor conditions to achieve precise positioning and controlled release, or amplify the efficacy of each drug to improve anticancer efficacy and reduce side effects. Compared with the traditional treatment, the application of cascade technology has achieved the controllability, specificity, and effectiveness of cancer treatment. This paper reviews the application of cascade technology in drug delivery, targeting, and release via nano-drug delivery systems in recent years, and introduces their application in reactive oxygen species (ROS)-induced cancer treatment. Finally, we briefly describe the current challenges and prospects of cascade technology in cancer treatment in the future.

scholarly journals Prodrug-based nano-drug delivery system for co-encapsulate paclitaxel and carboplatin for lung cancer treatment

Drug Delivery ◽  
2015 ◽  
Vol 23 (7) ◽  
pp. 2575-2580 ◽  
Author(s):  
Wen Zhang ◽  
Changzheng Li ◽  
Chengwu Shen ◽  
Yuguo Liu ◽  
Xiaoting Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lung Cancer Treatment ◽  
Nano Drug Delivery

scholarly journals Layer-by-Layer assembled nano-drug delivery systems for cancer treatment

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 655-669
Author(s):  
Xinyi Zhang ◽  
Tianying Liang ◽  
Qingming Ma
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Layer By Layer ◽  
Nano Drug Delivery

scholarly journals Liposomal Formulations In Cancer Therapy: Passive Versus Active Targeting

2019 ◽  
Vol 7 (2) ◽  
pp. 35-38
Author(s):  
Tosha Pandya ◽  
Kaushika Kaushika Patel ◽  
Rudree Pathak ◽  
Shreeraj Shah
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Active Targeting ◽  
Liposomal Drug ◽  
Passive Targeting ◽  
Liposomal Formulations ◽  
Nano Drug Delivery ◽  
Liposomal Drug Delivery

In Cancer therapy, Nano drug delivery system comprising of Liposomes, are the most successful mode of treatment in present scenario which also has real time clinical application. Recently it is found that the closed bilayer phospholipid vesicles have many technical advantages over the initially used liposomal formulations. The delivery of therapeutics encapsulated in liposomes changes the biological distribution profile and improves the drug therapeutic indices of various drugs. This review article throws light onto many clinical liposomal drug delivery products. The liposome Nano drug delivery by the active and passive targeting is a boon as it can reduce the off-targeting effects. The current development is more focused on the diagnostic and clinical applications. Receptor targeted delivery systems are extensively explored for active targeting. However, these delivery systems are rarely seen in the clinical application because of conjugation chemistry and other implicit hurdles to develop this system.The development of nanocarriers in the cancer treatment have enormous potential in the medical field. Moreover, Immuno liposomes have been used in cancer treatment as attractive drug targeting vehicles. On the other hand, there are many other liposomal drug delivery systems having passive targeting mechanism for cancer treatment which are widely used due to enhanced retention and permeability of formulation. This review majorly focuses on the current challenges encountered in development of liposomal Nano drug delivery systems and its effective development for cancer treatment.

scholarly journals A Review on Drug Delivery System for Tumor Therapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Guoxiang Liu ◽  
Lina Yang ◽  
Guang Chen ◽  
Fenghua Xu ◽  
Fanghao Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Antitumor Drugs ◽  
Drug Nanoparticles ◽  
Cancer Nanomedicine ◽  
Targeting Ability ◽  
Personalized Cancer

In recent years, with the development of nanomaterials, the research of drug delivery systems has become a new field of cancer therapy. Compared with conventional antitumor drugs, drug delivery systems such as drug nanoparticles (NPs) are expected to have more advantages in antineoplastic effects, including easy preparation, high efficiency, low toxicity, especially active tumor-targeting ability. Drug delivery systems are usually composed of delivery carriers, antitumor drugs, and even target molecules. At present, there are few comprehensive reports on a summary of drug delivery systems applied for tumor therapy. This review introduces the preparation, characteristics, and applications of several common delivery carriers and expounds the antitumor mechanism of different antitumor drugs in delivery carriers in detail which provides a more theoretical basis for clinical application of personalized cancer nanomedicine in the future.

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