Novel nano-drug delivery approach for breast cancer

2016 ◽  
Author(s):  
Islam Elkholi
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Nano Drug Delivery ◽  
Delivery Approach

scholarly journals A mitochondria-targeted delivery system of doxorubicin and evodiamine for the treatment of metastatic breast cancer

RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 37067-37078
Author(s):  
Xiaoyan Tan ◽  
Yanlin Zhou ◽  
Li Shen ◽  
Han Jia ◽  
Xiaorong Tan
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Metastatic Breast Cancer ◽  
Therapeutic Effect ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Metastatic Breast ◽  
Nano Drug Delivery ◽  
Targeted Delivery System

For mitochondria-targeted nano-drug delivery systems against cancer, effectively targeting and releasing the drug into mitochondria are the keys to improve the therapeutic effect.

Towards a targeted multi-drug delivery approach to improve therapeutic efficacy in breast cancer

2010 ◽  
Vol 7 (10) ◽  
pp. 1159-1173 ◽  
Author(s):  
Bin Wang ◽  
Jenna M Rosano ◽  
Rabe'e Cheheltani ◽  
Mohan P Achary ◽  
Mohammad F Kiani
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Delivery Approach

scholarly journals DOX-loaded pH-sensitive mesoporous silica nanoparticles coated with PDA and PEG induce pro-death autophagy in breast cancer

RSC Advances ◽  
2017 ◽  
Vol 7 (63) ◽  
pp. 39641-39650 ◽  
Author(s):  
Yanhong Duo ◽  
Yang Li ◽  
Changke Chen ◽  
Baiyun Liu ◽  
Xinyu Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Side Effects ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Cell Uptake ◽  
Uptake Efficiency ◽  
Chemotherapy Drugs ◽  
Nano Drug Delivery

The development of multifunctional nano drug delivery carriers has been one of the most effective and prevailing approaches to overcome drug non-selectivity, low cell uptake efficiency and various side effects of traditional chemotherapy drugs.

Experimental study on nuclear-targeted plasmid-based short hairpin RNA (ShRNA) to hypoxia inducible factor-1α (PshHIF-1α) PshHIF-1α nano-drug carrier system for breast cancer treatment in rats

2021 ◽  
Vol 11 (7) ◽  
pp. 1045-1050
Author(s):  
Gang Sun ◽  
Jin Zhang ◽  
Shuai Wu ◽  
Yun Liu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Flow Cytometry ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Apoptosis ◽  
Drug Carrier ◽  
Carrier System ◽  
Nano Drug Delivery ◽  
Drug Carrier System

This study was aimed at exploring the regulatory mechanism of auclear-targeted pshHIF-1α nano-drug carrier system (NPNCS) in the treatment of breast cancer in rats. MDA-MB-231 cell was cultured and DJ-1 and PTEN mRNA level was detected by qRT-PCR along with analysis of cell viability by CCK-8 and apoptosis by means of flow cytometry. The rats were assigned into control group, nuclear-targeted pshHIF-1α nanopharmaceutical system treatment group, and nuclear-targeted pshHIF-1α nano-pharmaceutical system+PTEN inhibitor SF1670 group, followed by analysis of cell proliferation by EdU staining, cell apoptosis by flow cytometry, and the levels of DJ-1, PTEN, and p-AKT. Compared with MDA-MB-231 cells treated with NPNCS, cells without intervention showed decreased PTEN and increased DJ-1 level. NPNCS induced cell apoptosis. Administration of nuclear-targeted pshHIF-1α nano-drug delivery system down-regulated DJ-1 and up-regulated PTEN. Combined treatment with SF1670 promoted p-AKT level and decreased the inhibitory effect of NPNCS on p-AKT level. In conclusion, the nuclear-targeted pshHIF-1α nano-drug delivery system down-regulated DJ-1 and exerted a tumor suppressor and pro-apoptotic effect, which wasrelated to p-AKT phosphorylation and up-regulation of PTEN.

scholarly journals Erratum: Corrigendum: Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in breast cancer cells: an improved nanomedicine strategy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Chandran Murugan ◽  
Kathirvel Rayappan ◽  
Ramar Thangam ◽  
Ramasamy Bhanumathi ◽  
Krishnamurthy Shanthi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Delivery Approach

Nano-drug delivery system as a model for the treatment of breast cancer

The Breast ◽  
2017 ◽  
Vol 32 ◽  
pp. S28-S29
Author(s):  
I.K.A. Alsabari ◽  
S.M. Thahab ◽  
A. Al-Shammari ◽  
B.H. Saadoon ◽  
Z. Allebban
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nano Drug Delivery

Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

2013 ◽  
Vol 40 (10) ◽  
pp. 1014
Author(s):  
Xiao-Hong HAO ◽  
Cui-Miao ZHANG ◽  
Xiao-Long LIU ◽  
Xing-Jie LIANG ◽  
Guang JIA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery
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