A new calculation formula to describe the dynamic pressure of water jet peening with elliptical nozzle for high-efficiency treatment

Water jet peening is a good potential method to control welding residual stresses. The water jet with elliptical nozzle can improve the treatment efficiency due to its large treatment area. In this article, the water jet velocity and dynamic pressure for different elliptical nozzle dimensions and standoff distances are discussed by numerical simulation. The results show that when the axial distance is 10 mm, the effective impact diameter of the elliptical nozzle a/b=8–12 is about 2 times or more than that of the circular nozzle. The length of the jet core of the elliptical nozzle is only related to the outlet structure and is independent of the inlet pressure. The correlation between the dimensionless core length of the elliptical water jet and its long and short axes is derived. When the ratio of the major axis to the minor axis is between 7 and 13, the core length of the elliptical water jet is 7–7.5 times that of its minor axis. Combining the suitable treatment area and dynamic pressure, the elliptical nozzle with an axis ratio of 8 is recommended to control the welding residual stress. Finally, a new formula for calculating dynamic pressure distribution is proposed for the elliptical nozzle water jet at different stages.

High Participant Satisfaction Achieved Using Cryolipolysis for Fat Reduction of the Abdomen and Flanks

Background Patient-reported outcome (PRO) data evaluating the physical and psychosocial impact of Cryolipolysis (CoolSculpting) treatment are limited. Objectives Assess multidimensional aspects of satisfaction following cryolipolysis treatment of the flanks and abdomen using a combination of PRO instruments. Methods This was a multi-national, prospective, single cohort, interventional study. The primary endpoint was the proportion of Satisfied or Very Satisfied participants with treatment at 12 weeks post final treatment. Secondary endpoints included satisfaction categorized by treatment area, total number of treatment cycles, baseline body mass index (BMI), and fat volume reduction measured by 3D photography at 12 weeks post final treatment. Exploratory endpoints assessed the physical and psychosocial impacts of treatment. Safety was monitored throughout the study. Results Of 112 participants who were treated, 74.1% were female. The mean age and BMI were 42.5 years and 24.9 kg/mg 2, respectively. Of the 106 evaluable participants, 89.6% were Satisfied or Very Satisfied with treatment results. Satisfaction was high regardless of body area(s), total number of treatment cycles, or baseline BMI. Mean (SD) fat volume reduction was 264.8 mL (411.4). Overall, 90.6% reported Noticeable or Very Noticeable fat reduction, 89.6% were Likely or Very Likely to treat additional areas, and 93.4% would recommend cryolipolysis to a friend. 24 (21.4%) participants reported treatment-emergent adverse events (AEs); 23 (20.5%) reported these as Adverse Device Effects (ADE). No serious device-related or unanticipated adverse effects occurred. Conclusions Cryolipolysis (CoolSculpting) for fat reduction of the flanks and/or abdomen was well-tolerated and associated with high levels of satisfaction across multidimensional PROs.

Characterisation of a Cold Atmospheric Pressure Plasma Torch for Medical Applications: Demonstration of Device Safety

The safety and effectiveness of plasma devices are of crucial importance for medical applications. This study presents the novel design of an atmospheric plasma torch (SteriPlas) and its characterisation. The SteriPlas was characterised to ascertain whether it is safe for application on human skin. The emission spectrum discharged from the SteriPlas was shown to be the same as the emission from the MicroPlaSter Beta. The UV emitted from the SteriPlas was measured, and the effective irradiance was calculated. The effective irradiance enabled the determination of the maximum UV exposure limits, which were shown to be over two hours: significantly longer than the current two-minute treatment time. The use of an extraction system with a higher flow rate appears to reduce slightly the effective irradiance at the treatment area. The NOx and ozone emissions were recorded for both SteriPlas configurations. The NOx levels were shown to be orders of magnitude lower than their safety limits. The ozone emissions were shown to be safe 25 mm from the SteriPlas cage. A discussion of how safety standards differ from one regulatory body to another is given.

High-Capacity Real-Time Face Retrieval Recognition Algorithm Based on Task Scheduling Model for the Treatment Area of Hospital

This paper presents an in-depth study of face detection, face feature extraction, and face classification from three important components of a high-capacity face recognition system for the treatment area of hospital and a study of a high-capacity real-time face retrieval and recognition algorithm for the treatment area of hospital based on a task scheduling model. Considering the real-time nature of our system, our face feature extraction network is modeled by DeepID, and the network is slightly improved by introducing a central loss verification signal to train a DeepID-like network model using central loss and use it to extract face features. To further investigate and optimize the schedulability analysis problem of the directed graph real-time task model, this paper proposes a rigorous and approximate response time analysis method for the directed graph real-time task model with an arbitrary time frame. Based on the theoretical results of the greatly additive algebra, it is shown that the coherent qualifying function is linearly periodic, i.e., the function can be represented by a finite nonperiodic part and an infinitely repeated periodic part, thus calculating the coherent qualifying function independent of the magnitude of the interval time. The algorithm for high-capacity real-time face retrieval and recognition in the treatment area of hospital based on the task scheduling model is further investigated, and a face database is established by using the PCA dimensionality reduction technique. Based on the internal architecture of the processor, image preprocessing and IP core packaging are implemented, and the hardware engineering of the high-capacity real-time face recognition system for hospital visits is built using the IP-based design concept. The performance tests of the face detection model and feature extraction network show that the face detection model has a significant reduction in false-positive rate, better fitting of border regression, and improved time performance. The face feature extraction network has no overfitting, and the features are highly discriminative with small feature extraction time consumption. The high-capacity real-time face recognition system for the treatment area of hospital combined with the optimized directed graph task scheduling model can approach 25 fps, which meets the real-time requirements, and the face recognition rate surpasses that of real people. It realizes the intelligence, self-help, and autonomy of medical services and satisfies the medical needs of users in all aspects.

Laser synthesis of a weakly agglomerated aluminium oxide nanopowder doped with terbium and ytterbium

This paper describes a method of femtosecond laser synthesis of nanoparticles of powdered aluminum oxide doped with terbium and ytterbium was developed. The formation of a plasma torch of nanoparticles of a powdery material is carried out as a result of ablation under the influence of a sharply focused beam of femtosecond laser radiation with an intensity of 108- 1010W/m2. The radiation source is the TETA-10 laser system. SEM images of the obtained nanopowders are presented. Spherical nanoparticles of narrow particle size distribution in the range from 5 to 15 nm was synthesized with the ability to control the size of nanoparticles by purposefully changing the parameters and characteristics of pulsed radiation in the treatment area. The design of a specialized high-voltage electrostatic precipitator up to 25 kV for capturing ablated nanoparticles in an electron cloud of increased concentration was developed.

Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions

BackgroundLocal recurrence of esophageal squamous cell neoplasia (ESCN) and metachronous ESCN was associated with severe background esophageal multiple Lugol-voiding lesions (LVLs) even though the primary early ESCNs were treated with endoscopic resection (ER). The aim of this study is to explore the feasibility and effectiveness of combination treatments of ER and radiofrequency ablation (RFA) in patients with early ESCNs with synchronous multiple LVLs.MethodsA total of 329 patients with early ESCNs and synchronous multiple LVLs received ER combined with RFA from September 2010 to September 2020. Clinical and pathological features and treatment outcomes were retrospectively reviewed using medical records. Factors associated with background esophageal multiple LVLs before combined treatment were analyzed.ResultsThe proportion of complete response (CR) was 96.7% after primary RFA, while 90.3% patients achieved CR for the last endoscopic examinations regardless if inside or outside the treatment area (TA). Degeneration of background esophageal multiple LVLs occurred in 70.2% of patients. The grade of background esophageal multiple LVLs before combined treatment was closely related to gender, smoking, and drinking. The incidence of metachronous ESCNs outside the TA of ER and local recurrence in the TA of ER was 3.9% and 1.2%, respectively.ConclusionsProphylactic RFA treatment of multiple LVLs together with ER treatment of the primary ESCNs may be effective in reducing the incidence of metachronous ESCNs and local recurrence through improving the background esophageal mucosa.

How do patients respond to safety problems in ambulatory care? Results of a retrospective cross-sectional telephone survey

ObjectivesPatients in German ambulatory care frequently report patient safety problems (PSP). It is unclear whether patients report PSP back to their general practitioner (GP) or specialist in charge. This study reports on how patients respond to experienced PSP.DesignRetrospective cross-sectional study.SettingComputer-assisted telephone interviews (CATI) with randomly recruited citizens aged ≥40 years in Germany.Participants10 037 citizens ≥40 years. About 52% of the interviewees were female, 38% were between 60 and 79 years old and about 47% reported that they were chronically ill. A total of 2589 PSPs was reported.Primary and secondary measures/ResultsAccording to the respondents (n=1422, 77%, 95% CI: 74.7 to 79.1), 72% (95% CI: 70.2 to 73.7) of PSP were reported back to the GP in charge or to another GP/specialist. Further reactions were taken by 65% (95% CI: 62.5 to 67.5) of the interviewees: around 63% (95% CI: 62.5 to 66.2) of the reported PSP led to a loss of faith in the physician or to complaints. χ2 and binary logistic regression analyses show significant associations between the (a) reporting and (b) reaction behaviour and determinants like ‘medical treatment area’ ((a) χ2=17.13, p=0.009/(b) χ2=97.58, p=0.000), ‘PSP with/without harm’ ((a) χ2=111.84, p=0.000/(b) χ2=265.39, p=0.000) and sociodemographic characteristics when respondents are aged between 40 and 59 years ((a) OR 2.57/(b) OR 2.60) or have chronic illnesses ((a) OR 2.16/(b) OR 2.14).ConclusionThe data suggest that PSPs are frequently reported back to the GP or specialist in charge and have a significant serious impact on the physician–patient relationship. Much could be learnt from the patient reporting and reacting behaviour to prevent PSPs in ambulatory care.

Selective Metallization on CFRP Composites by Laser Radiation and Electroless Plating

Selective metallization of carbon fiber-reinforced polymer composites (CFRP) was conducted by laser ablation with 1064 nm laser radiation and electroless plating in nickel solution. A rough caterpillar-like structure and polar surface with high property of absorption and anchoring for active seeds were produced by laser ablation. The laser treatment produce had a pronounced influence on nickel deposition. After immersed in nickel solution for 150s, a homogeneous and dense nickel film was selectively deposited on the laser treatment area of CFRP by electroless plating successfully. The Ni plating exhibited excellent adhesion on the CFRP. The technique in this study would widespread the application of CFRP in the area of spacecraft microwave components and waveguide antenna.

PI-D CONTROLLER BASED ON AN IMPROVED CROW SEARCH ALGORITHM FOR CANCER GROWTH TREATMENT

The number of cancer diagnoses and deaths worldwide is rising every year despite technological advancements in diagnosing and treating multiple forms of cancer. An oncolytic virus is a type of tumour-killing virus that can infect and analyze cancer cells while mostly preserving normal cells. The oncolytic Vesicular-Stomatitis Virus therapeutic's cell cycle-specific action mathematically investigated. An optimal Proportion Integral-Derivative (PI-D) controller is introduced in this paper based on a suggested Improved Crow Search Algorithm (ICSA) to enhance the outcome of oncolytic virotherapy. The control technique was tested in a computer using MATLAB simulation. The suggested ICSA is used to tune the parameters of the PI-D controller. The ICSA used the inertia factor and boundary handle mechanism in the position update equation to balance exploration and exploitation. The simulation results show that decrease in total dose, tumour cells to 30%, the tumour remain in the treatment area from day 30 onwards. Furthermore, the ICSA algorithm outperforms the CSA and PSO algorithms by 34.5497×10-6 and 15.2573 ×10-6, respectively, indicating the robustness of treatment methods that can accomplish tumour reduction through biological parameters ambiguity.

Dark cytotoxicity of submicrometer vaterite particles loaded with photosensitizer Fotoditazin and the vaterite-based core – shells structures

Photodynamic therapy (PDT) is based on the use of photosensitizers together with a light at the wavelength corresponding to its absorption maximum. Photosensitizers are able to generate reactive oxygen species under the visible or infrared light irradiation. They are broadly used for the treatment of cancer and infections due to their physical and chemical properties. Dose-dependent light induced cytotoxicity of photosensitizers shows the strong relation between its concentration in the treatment area and PDT efficiency. With this regard, the development of novel carriers for targeted delivery of photosensitizers is a very prospective research direction, as allows for the enhancement of the local drug concentration in the treatment area and the reduction of the incidental dark toxicity in healthy tissue associated with a classic PDT. Mesoporous vaterite particles are considered as a promising tool for biomedical application due to their biodegradability, high payload ability, as well as to the simplicity and cheapness of their fabrication. The efficiency of vaterite carrier application for a PDT delivery system design has been previously demonstrated. With this regard, the current study was aimed at the evaluation of dark cytotoxicity of the submicron vaterite particles and the vaterite-based core-shells, both loaded with Fotoditazin photosensitizer.