scholarly journals Chitosan/Poly Vinyl Alcohol/Graphene Oxide Based pH-Responsive Composite Hydrogel Films: Drug Release, Anti-Microbial and Cell Viability Studies

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3124
Author(s):  
Muhammad Umar Aslam Khan ◽  
Zahida Yaqoob ◽  
Mohamed Nainar Mohamed Ansari ◽  
Saiful Izwan Abd Razak ◽  
Mohsin Ali Raza ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Cell Viability ◽  
Critical Concentration ◽  
Composite Hydrogel ◽  
Poly Vinyl Alcohol ◽  
Drug Release Profile ◽  
Force Microscopy ◽  
Composite Hydrogels ◽  
Hydrogel Composite

The composite hydrogels were produced using the solution casting method due to the non-toxic and biocompatible nature of chitosan (CS)/polyvinyl alcohol (PVA). The best composition was chosen and crosslinked with tetraethyl orthosilicate (TEOS), after which different amounts of graphene oxide (GO) were added to develop composite hydrogels. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM) and contact angle was used to analyze the hydrogels. The samples were also evaluated for swelling abilities in various mediums. The drug release profile was studied in phosphate-buffered saline (PBS) at a pH of 7.4. To predict the mechanism of drug release, the data were fitted into kinetic models. Finally, antibacterial activity and cell viability data were obtained. FTIR studies revealed the successful synthesis of CS/PVA hydrogels and GO/CS/PVA in hydrogel composite. SEM showed no phase separation of the polymers, whereas AFM showed a decrease in surface roughness with an increase in GO content. 100 µL of crosslinker was the critical concentration at which the sample displayed excellent swelling and preserved its structure. Both the crosslinked and composite hydrogel showed good swelling. The most acceptable mechanism of drug release is diffusion-controlled, and it obeys Fick’s law of diffusion for drug released. The best fitting of the zero-order, Hixson-Crowell and Higuchi models supported our assumption. The GO/CS/PVA hydrogel composite showed better antibacterial and cell viability behaviors. They can be better biomaterials in biomedical applications.

scholarly journals Electrospun Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide Nanofibrous Membrane with Ciprofloxacin Antibiotic Drug for Potential WoundDressing Application

2019 ◽  
Vol 20 (18) ◽  
pp. 4395 ◽  
Author(s):  
Yang ◽  
Zhang ◽  
Zhang
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Burst Release ◽  
Drug Release Profile ◽  
Electrospinning Technique ◽  
Antibiotic Drugs ◽  
Antibiotic Drug ◽  
Nanofibrous Membranes

In this paper, nanofibrous membranes based on chitosan (CS), poly (vinyl alcohol) (PVA) and graphene oxide (GO) composites, loaded with antibiotic drugs, such as Ciprofloxacin (Cip) and Ciprofloxacin hydrochloride (CipHcl) were prepared via the electrospinning technique. The uniform and defect-free CS/PVA nanofibers were obtained and GO nanosheets, shaping spindle and spherical, were partially embedded into nanofibers. Besides, the antibiotic drugs were effectively loaded into the nanofibers and part of which were absorbed into GO nanosheets. Intriguingly, the release of the drug absorbed in GO nanosheets regulated the drug release profile trend, avoiding the “burst” release of drug at the release initial stage, and the addition of GO slightly improved the drug release ratio. Nanofibrous membranes showed the significantly enhanced antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis after the addition of antibiotic drug. Moreover, the drug-loaded nanofibrous membranes exhibited excellent cytocompatibility with Melanoma cells, indicative to the great potential potential for applications in wound dressing.

Near infrared photothermal-responsive poly(vinyl alcohol)/black phosphorus composite hydrogels with excellent on-demand drug release capacity

2018 ◽  
Vol 6 (11) ◽  
pp. 1622-1632 ◽  
Author(s):  
Guanghui Yang ◽  
Xuejuan Wan ◽  
Zhipeng Gu ◽  
Xierong Zeng ◽  
Jiaoning Tang
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Vinyl Alcohol ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Poly Vinyl Alcohol ◽  
Composite Hydrogels ◽  
On Demand ◽  
Release Capacity ◽  
Good Biocompatibility

Novel PVA/pBP hydrogels with highly effective NIR-responsive drug release performance, robust mechanical properties and good biocompatibility were prepared.

Graphene Oxide Containing Composite Hydrogel Fabricated by Freeze/Thaw Method

2012 ◽  
Vol 430-432 ◽  
pp. 1028-1031 ◽  
Author(s):  
Wen Chao Wang ◽  
Zhi Liang Li ◽  
Jian Juan Wu ◽  
Mao Cong Yi ◽  
Yu Liu ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Graphene Oxide ◽  
Polymer Matrix ◽  
Vinyl Alcohol ◽  
Load Transfer ◽  
Poly Vinyl Alcohol ◽  
Structure And Properties ◽  
Freeze Thaw ◽  
Composite Hydrogels ◽  
Inorganic Fillers

Graphene oxide (GO) was used as inorganic fillers to enhance the mechanic properties of graphene oxide/poly(vinyl alcohol) composite hydrogels that were prepared by freeze/thaw method. The structure and properties of the composite hydrogels were characterized. Since GO was well dispersed in polymer matrix, the composite hydrogels showed an outstanding mechanical improvement. Significant increase in Young's modulus and compressive strength was achieved, indicating a good load transfer between fillers and matrix.

scholarly journals Enhanced Mechanical and Antibacterial Properties of Nanocomposites Based on Poly(vinyl Alcohol) and Biopolymer-Derived Reduced Graphene Oxide

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 615
Author(s):  
Beom-Gon Cho ◽  
Shalik Ram Joshi ◽  
Seongjin Lee ◽  
Shin-Kwan Kim ◽  
Young-Bin Park ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Vinyl Alcohol ◽  
Bacterial Colonization ◽  
Low Cost ◽  
Critical Concentration ◽  
Antibacterial Properties ◽  
Single Step ◽  
Poly Vinyl Alcohol ◽  
Reduced Graphene

Functionalized graphene–polymer nanocomposites have gained significant attention for their enhanced mechanical, thermal, and antibacterial properties, but the requirement of multi-step processes or hazardous reducing agents to functionalize graphene limits their current applications. Here, we present a single-step synthesis of thermally reduced graphene oxide (TrGO) based on shellac, which is a low-cost biopolymer that can be employed to produce poly(vinyl alcohol) (PVA)/TrGO nanocomposites (PVA–TrGO). The concentration of TrGO varied from 0.1 to 2.0 wt.%, and the critical concentration of homogeneous TrGO dispersion was observed to be 1.5 wt.%, below which strong interfacial molecular interactions between the TrGO and the PVA matrix resulted in improved thermal and mechanical properties. At 1.5 wt.% filler loading, the tensile strength and modulus of the PVA–TrGO nanocomposite were increased by 98.7% and 97.4%, respectively, while the storage modulus was increased by 69%. Furthermore, the nanocomposite was 96% more effective in preventing bacterial colonization relative to the neat PVA matrix. The present findings indicate that TrGO can be considered a promising material for potential applications in biomedical devices.

scholarly journals Properties and structural characterization of chitosan/poly(vinyl alcohol)/graphene oxide nano composites

e-Polymers ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Jun Ma ◽  
Changhua Liu ◽  
Rui Li ◽  
Jia Wang
Keyword(s):  
Graphene Oxide ◽  
Vinyl Alcohol ◽  
Tensile Testing ◽  
Nanocomposite Films ◽  
Poly Vinyl Alcohol ◽  
Gravimetric Analysis ◽  
Scanning Calorimetry ◽  
Force Microscopy ◽  
Atomic Force ◽  
Uniform Dispersion

AbstractChitosan (CS)/poly(vinyl alcohol) (PVA)/graphene oxide (GO) nanocomposites in the form of films are prepared in a casting and solvent evaporation method. Fourier-transform infrared spectroscopy (FTIR), X-ray diffractions (XRD), atomic force microscopy (AFM), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), tensile testing and moisture uptake were used to study the structure and properties of these chitosan/poly(vinyl alcohol) /graphene oxide (PCS/GO-n) nanocomposites. The result from tensile testing indicated that the nanocomposite containing 2 wt% GO exhibits high tensile strength (71.21 MPa) with a large elongation at break (51.8%). The high mechanical properties of the nanocomposite films are mainly due to uniform dispersion of GO sheets in the polymer matrix and strong interfacial interactions among components.

Fabrication of poly(vinyl alcohol)–graphene oxide–polypyrrole composite hydrogel for elastic supercapacitors

2020 ◽  
Vol 55 (25) ◽  
pp. 11779-11791
Author(s):  
Duanli Wei ◽  
Jiaqing Zhu ◽  
Licheng Luo ◽  
Huabo Huang ◽  
Liang Li ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Vinyl Alcohol ◽  
Composite Hydrogel ◽  
Poly Vinyl Alcohol ◽  
Polypyrrole Composite

scholarly journals Microplasma-assisted hydrogel fabrication: A novel method for gelatin-graphene oxide nano composite hydrogel synthesis for biomedical application

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3498 ◽  
Author(s):  
Mantosh Kumar Satapathy ◽  
Wei-Hung Chiang ◽  
Er-Yuan Chuang ◽  
Chih-Hwa Chen ◽  
Jia-Liang Liao ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Contact Angle ◽  
Graphene Oxide ◽  
Cell Viability ◽  
Mtt Assay ◽  
Composite Hydrogel ◽  
Swelling Behavior ◽  
Great Promise ◽  
Cross Linking ◽  
Nano Composite

Toxicity issues and biocompatibility concerns with traditional classical chemical cross-linking processes prevent them from being universal approaches for hydrogel fabrication for tissue engineering. Physical cross-linking methods are non-toxic and widely used to obtain cross-linked polymers in a tunable manner. Therefore, in the current study, argon micro-plasma was introduced as a neutral energy source for cross-linking in fabrication of the desired gelatin-graphene oxide (gel-GO) nanocomposite hydrogel scaffolds. Argon microplasma was used to treat purified gelatin (8% w/v) containing 0.1∼1 wt% of high-functionality nano-graphene oxide (GO). Optimized plasma conditions (2,500 V and 8.7 mA) for 15 min with a gas flow rate of 100 standard cm3/min was found to be most suitable for producing the gel-GO nanocomposite hydrogels. The developed hydrogel was characterized by the degree of cross-linking, FTIR spectroscopy, SEM, confocal microscopy, swelling behavior, contact angle measurement, and rheology. The cell viability was examined by an MTT assay and a live/dead assay. The pore size of the hydrogel was found to be 287 ± 27 µm with a contact angle of 78° ± 3.7°. Rheological data revealed improved storage as well as a loss modulus of up to 50% with tunable viscoelasticity, gel strength, and mechanical properties at 37 °C temperature in the microplasma-treated groups. The swelling behavior demonstrated a better water-holding capacity of the gel-GO hydrogels for cell growth and proliferation. Results of the MTT assay, microscopy, and live/dead assay exhibited better cell viability at 1% (w/w) of high-functionality GO in gelatin. The highlight of the present study is the first successful attempt of microplasma-assisted gelatin-GO nano composite hydrogel fabrication that offers great promise and optimism for further biomedical tissue engineering applications.

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