scholarly journals Electrospun Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide Nanofibrous Membrane with Ciprofloxacin Antibiotic Drug for Potential WoundDressing Application

2019 ◽  
Vol 20 (18) ◽  
pp. 4395 ◽  
Author(s):  
Yang ◽  
Zhang ◽  
Zhang
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Burst Release ◽  
Drug Release Profile ◽  
Electrospinning Technique ◽  
Antibiotic Drugs ◽  
Antibiotic Drug ◽  
Nanofibrous Membranes

In this paper, nanofibrous membranes based on chitosan (CS), poly (vinyl alcohol) (PVA) and graphene oxide (GO) composites, loaded with antibiotic drugs, such as Ciprofloxacin (Cip) and Ciprofloxacin hydrochloride (CipHcl) were prepared via the electrospinning technique. The uniform and defect-free CS/PVA nanofibers were obtained and GO nanosheets, shaping spindle and spherical, were partially embedded into nanofibers. Besides, the antibiotic drugs were effectively loaded into the nanofibers and part of which were absorbed into GO nanosheets. Intriguingly, the release of the drug absorbed in GO nanosheets regulated the drug release profile trend, avoiding the “burst” release of drug at the release initial stage, and the addition of GO slightly improved the drug release ratio. Nanofibrous membranes showed the significantly enhanced antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis after the addition of antibiotic drug. Moreover, the drug-loaded nanofibrous membranes exhibited excellent cytocompatibility with Melanoma cells, indicative to the great potential potential for applications in wound dressing.

scholarly journals Chitosan/Poly Vinyl Alcohol/Graphene Oxide Based pH-Responsive Composite Hydrogel Films: Drug Release, Anti-Microbial and Cell Viability Studies

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3124
Author(s):  
Muhammad Umar Aslam Khan ◽  
Zahida Yaqoob ◽  
Mohamed Nainar Mohamed Ansari ◽  
Saiful Izwan Abd Razak ◽  
Mohsin Ali Raza ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Cell Viability ◽  
Critical Concentration ◽  
Composite Hydrogel ◽  
Poly Vinyl Alcohol ◽  
Drug Release Profile ◽  
Force Microscopy ◽  
Composite Hydrogels ◽  
Hydrogel Composite

The composite hydrogels were produced using the solution casting method due to the non-toxic and biocompatible nature of chitosan (CS)/polyvinyl alcohol (PVA). The best composition was chosen and crosslinked with tetraethyl orthosilicate (TEOS), after which different amounts of graphene oxide (GO) were added to develop composite hydrogels. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM) and contact angle was used to analyze the hydrogels. The samples were also evaluated for swelling abilities in various mediums. The drug release profile was studied in phosphate-buffered saline (PBS) at a pH of 7.4. To predict the mechanism of drug release, the data were fitted into kinetic models. Finally, antibacterial activity and cell viability data were obtained. FTIR studies revealed the successful synthesis of CS/PVA hydrogels and GO/CS/PVA in hydrogel composite. SEM showed no phase separation of the polymers, whereas AFM showed a decrease in surface roughness with an increase in GO content. 100 µL of crosslinker was the critical concentration at which the sample displayed excellent swelling and preserved its structure. Both the crosslinked and composite hydrogel showed good swelling. The most acceptable mechanism of drug release is diffusion-controlled, and it obeys Fick’s law of diffusion for drug released. The best fitting of the zero-order, Hixson-Crowell and Higuchi models supported our assumption. The GO/CS/PVA hydrogel composite showed better antibacterial and cell viability behaviors. They can be better biomaterials in biomedical applications.

Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile

2015 ◽  
Vol 64 (12) ◽  
pp. 1722-1732 ◽  
Author(s):  
Betiana Felice ◽  
Molamma P Prabhakaran ◽  
Maedeh Zamani ◽  
Andrea P Rodríguez ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Release ◽  
Vinyl Alcohol ◽  
Release Profile ◽  
Poly Vinyl Alcohol ◽  
Drug Release Profile ◽  
Preparation And Evaluation

Development of zeolite-A incorporated PVA/CS nanofibrous composite membranes using the electrospinning technique for pervaporation dehydration of water/tert-butanol

2021 ◽  
Author(s):  
Divya D. Achari ◽  
Sachin N. Hegde ◽  
Nandini A. Pattanashetti ◽  
Ravindra R. Kamble ◽  
Mahadevappa Y. Kariduraganavar
Keyword(s):  
Vinyl Alcohol ◽  
Composite Membranes ◽  
Poly Vinyl Alcohol ◽  
Zeolite A ◽  
Electrospinning Technique ◽  
Tert Butanol ◽  
Nanofibrous Membranes

Using the electrospinning technique, composite nanofibrous membranes were developed on a dense PVA layer from a solution of poly(vinyl alcohol) (PVA)/chitosan (CS)/zeolite-A.

Preparation of Poly(vinyl alcohol)/Polyoxalate Composite Nanofibers by Electrospinning and Drug Release Profiles

2014 ◽  
Vol 894 ◽  
pp. 369-373
Author(s):  
Nutthakritta Phromviyo ◽  
Ekaphan Swatsitang ◽  
Apiwat Chompoosor
Keyword(s):  
Drug Release ◽  
Rhodamine B ◽  
Vinyl Alcohol ◽  
In Vitro Release ◽  
Control Release ◽  
Electrospun Nanofibers ◽  
Average Diameter ◽  
Poly Vinyl Alcohol ◽  
Electrospinning Technique

This study investigated the use of a biodegradable polyoxalate blended with poly (vinyl alcohol) nanofibers to tailor properties of nanofibers and to control release of Rhodamine B from nanofibers. Nanofibers were prepared using an electrospinning technique. The morphology and average diameter of electrospun nanofibers were investigated using scanning electron microscopy. It was found that poly (vinyl alcohol) to polyoxalate ratio had a significant effect on the size of nanofibers (~175-403 nm). An in vitro release study showed that rate of Rhodamine B release increased with increasing poly (vinyl alcohol)/polyoxalate ratios yielding rate of release in the range of 0.1980.469 mg%/min. The mechanism of rhodamine B release can be explained by a two-stage process of diffusion and degradation. The results suggested that a water-insoluble polyoxalate could govern the rate of drug release. The ability to tune the release of chemicals from nanofibers has significant implications for controlled release of drugs.

scholarly journals Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2351
Author(s):  
Zheng Su ◽  
Daye Sun ◽  
Li Zhang ◽  
Miaomiao He ◽  
Yulin Jiang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Graphene Oxide ◽  
Drug Release ◽  
Release Rate ◽  
Composite System ◽  
Methyl Blue ◽  
Burst Release ◽  
Fluorescein Sodium ◽  
Photothermal Conversion ◽  
Dual Drug

In this work, we designed and fabricated a multifunctional nanocomposite system that consists of chitosan, raspberry-like silver nanoparticles, and graphene oxide. The room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environmentally-friendly method for introducing silver nanoparticles into the composite system. Our composite can achieve a pH controlled single and/or dual drug release. Under pH 7.4 for methyl blue loaded on chitosan, the drug release profile features a burst release during the first 10 h, followed by a more stabilized release of 70–80% after 40–50 h. For fluorescein sodium loaded on graphene oxide, the drug release only reached 45% towards the end of 240 h. When the composite acted as a dual drug release system, the interaction of fluorescein sodium and methyl blue slowed down the methyl blue release rate. Under pH 4, both single and dual drug systems showed a much higher release rate. In addition, our composite system demonstrated strong antibacterial abilities against E. coli and S. aureus, as well as an excellent photothermal conversion effect under irradiation of near infrared lasers. The photothermal conversion efficiency can be controlled by the laser power. These unique functionalities of our nanocomposite point to its potential application in multiple areas, such as multimodal therapeutics in healthcare, water treatment, and anti-microbials, among others.

scholarly journals Novel Hydrogels of Chitosan and Poly (vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 691
Author(s):  
O. Sánchez-Aguinagalde ◽  
Ainhoa Lejardi ◽  
Emilio Meaurio ◽  
Rebeca Hernández ◽  
Carmen Mijangos ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Bioactive Glass ◽  
Vinyl Alcohol ◽  
Release Kinetics ◽  
The Body ◽  
Poly Vinyl Alcohol ◽  
X Ray Diffraction ◽  
Inorganic Particles ◽  
Release Studies

Chitosan (CS) and poly (vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to reinforce these gels with inorganic glass particles (BG) in order to improve mechanical properties and bioactivity and to see how this reinforcement affects levofloxacin drug release kinetics. Scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, rheology and drug release studies characterized the resulting hydrogels. The experimental results verified the bioactivity of these gels, showed an improvement of the mechanical properties and proved that the added bioactive glass does affect the release kinetics.

Sign in / Sign up

Export Citation Format

Share Document