scholarly journals Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1317 ◽  
Author(s):  
Sadaf Samimi Gharaie ◽  
Seyed Dabiri ◽  
Mohsen Akbari
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Total Solid ◽  
Shear Thinning ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Physiological Conditions ◽  
Optimum Formulation ◽  
Localized Drug Delivery ◽  
Sensitive Behavior

In this study, we fabricated and characterized a smart shear-thinning hydrogel composed of gelatin and laponite for localized drug delivery. We added chitosan (Chi) and poly N-isopropylacrylamide-co-Acrylic acid (PNIPAM) particles to the shear-thinning gel to render it pH-responsive. The effects of total solid weight and the percentage of laponite in a solid mass on the rheological behavior and mechanical properties were investigated to obtain the optimum formulation. The nanocomposite gel and particles were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), zeta potential, and dynamic light scattering techniques. Finally, release related experiment including degradability, swelling and Rhodamine B (Rd) release at various pH were performed. The results suggest that incorporation of silicate nanoplatelets in the gelatin led to the formation of the tunable porous composite, with a microstructure that was affected by introducing particles. Besides, the optimum formulation possessed shear-thinning properties with modified rheological and mechanical properties which preserved its mechanical properties while incubated in physiological conditions. The release related experiments showed that the shear-thinning materials offer pH-sensitive behavior so that the highest swelling ratio, degradation rate, and Rd release were obtained at pH 9.18. Therefore, this nanocomposite gel can be potentially used to develop pH-sensitive systems.

Transport in Pulsatile Axisymmetric Stented Arterial Models From Location-Dependent Variations in Permeability and Mechanical Properties

2011 ◽  
Author(s):  
Joseph T. Keyes ◽  
Bruce R. Simon ◽  
Jonathan P. Vande Geest
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Relative Influence ◽  
Drug Eluting Stents ◽  
Diffusive Transport ◽  
Antiproliferative Effects ◽  
Drug Eluting ◽  
Tissue System ◽  
Localized Drug Delivery ◽  
Insight Into

Drug-eluting stents (DESs) perform their antiproliferative effects through the use of localized drug delivery. The delivery may be computationally modeled to determine efficacy of the DES-tissue system and utilizes coupled convective and diffusive transport. Since the movement of solutes through the wall is via the coupled effects of convective and diffusive transport, the relative influence of these factors provides insight into the governing forces of localized DES drug delivery [1].

Glutathione functionalized mesoporous organosilica conjugate for drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56287-56293 ◽  
Author(s):  
Lin-Lin Hu ◽  
Dan-Dan Zhang ◽  
Yang Zhang ◽  
Yang Shu ◽  
Xu-Wei Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polyacrylic Acid ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Mesoporous Organosilica

We developed a novel pH-responsive drug delivery system based on permeation-enhancing glutathione (GSH) and pH sensitive polyacrylic acid (PAA) grafted mesoporous organosilica nanocarriers (MONs).

Synthesis of pH-responsive hydrogel thin films grafted on PCL substrates for protein delivery

2015 ◽  
Vol 3 (39) ◽  
pp. 7673-7681 ◽  
Author(s):  
Lihua Zhang ◽  
Yuhong Ma ◽  
Changwen Zhao ◽  
Xing Zhu ◽  
Ruichao Chen ◽  
...  
Keyword(s):  
Thin Films ◽  
Drug Delivery ◽  
Visible Light ◽  
Protein Delivery ◽  
Graft Polymerization ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Polymer Substrates ◽  
Polymerization Method ◽  
Ph Sensitive Hydrogel

A new visible light induced graft polymerization method was utilized to prepare pH-sensitive hydrogel layers covalently attached to polymer substrates for drug delivery.

A pH-responsive drug delivery system with an aggregation-induced emission feature for cell imaging and intracellular drug delivery

2015 ◽  
Vol 6 (26) ◽  
pp. 4715-4718 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Haiqi Gao ◽  
Yunbing Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Imaging ◽  
Emission Feature ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Therapeutic Treatment ◽  
Aggregation Induced Emission ◽  
Intracellular Drug Delivery

A pH-sensitive fluorescent vehicle based on aggregation-induced emission (AIE) has been developed as a drug delivery system for simultaneous cell imaging and therapeutic treatment.

scholarly journals Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 963 ◽  
Author(s):  
Omar Mertins ◽  
Patrick D. Mathews ◽  
Angelina Angelova
Keyword(s):  
Drug Delivery ◽  
Oral Delivery ◽  
Liquid Crystalline ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Water Soluble ◽  
Cubic Phase ◽  
Ph Responsive ◽  
X Ray ◽  
Lipid Fatty Acid

Nanostructure bicontinuous cubic phase self-assembled materials are receiving expanding applications as biocompatible delivery systems in various therapeutic fields. The functionalization of cubosome, spongosome, hexosome and liposome nanocarriers by pH-sensitive lipids and/or pH-sensitive polymer shells offers new opportunities for oral and topical drug delivery towards a new generation of cancer therapies. The electrochemical behavior of drug compounds may favor pH-triggered drug release as well. Here, we highlight recent investigations, which explore the phase behavior of mixed nonlamellar lipid/fatty acid or phospholipid systems for the design of pH-responsive and mucoadhesive drug delivery systems with sustained-release properties. X-ray diffraction and small-angle X-ray scattering (SAXS) techniques are widely used in the development of innovative delivery assemblies through detailed structural analyses of multiple amphiphilic compositions from the lipid/co-lipid/water phase diagrams. pH-responsive nanoscale materials and nanoparticles are required for challenging therapeutic applications such as oral delivery of therapeutic proteins and peptides as well as of poorly water-soluble substances. Perspective nanomedicine developments with smart cubosome nanocarriers may exploit compositions elaborated to overcome the intestinal obstacles, dual-drug loaded pH-sensitive liquid crystalline architectures aiming at enhanced therapeutic efficacy, as well as composite (lipid/polyelectrolyte) types of mucoadhesive controlled release colloidal cubosomal formulations for the improvement of the drugs’ bioavailability.

scholarly journals Strategy to design a smart photocleavable and pH sensitive chitosan based hydrogel through a novel crosslinker: a potential vehicle for controlled drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (25) ◽  
pp. 14694-14704 ◽  
Author(s):  
Safiya Nisar ◽  
Ashiq Hussain Pandit ◽  
Li-Fang Wang ◽  
Sunita Rattan
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Ph Sensitive ◽  
Stimuli Responsive ◽  
Ph Responsive

We report the synthesis of a novel photocleavable crosslinker and its joining with amine-based polysachharides, viz. chitosan, resulting in the formation of a dual stimuli-responsive hydrogel having UV- and pH-responsive sites.

Acetalated-dextran as valves of mesoporous silica particles for pH responsive intracellular drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (13) ◽  
pp. 9546-9555 ◽  
Author(s):  
Zhe Lin ◽  
Jizhen Li ◽  
Hongyan He ◽  
Huihui Kuang ◽  
Xuesi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Anticancer Drugs ◽  
Silica Particles ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Release System ◽  
Intracellular Drug Delivery ◽  
Intracellular Release

A pH-sensitive drug release system using acetalated-dextran as valves was designed to manipulate smart intracellular release of anticancer drugs.

scholarly journals Tuning the aggregation behavior of pH-responsive micelles by copolymerization

2015 ◽  
Vol 6 (14) ◽  
pp. 2761-2768 ◽  
Author(s):  
Daniel B. Wright ◽  
Joseph P. Patterson ◽  
Anaïs Pitto-Barry ◽  
Pepa Cotanda ◽  
Christophe Chassenieux ◽  
...  
Keyword(s):  
Diblock Copolymers ◽  
Analytical Techniques ◽  
Ph Sensitive ◽  
Aggregation Behavior ◽  
Ph Responsive ◽  
Highly Sensitive ◽  
Amphiphilic Diblock Copolymers ◽  
Sensitive Behavior

A series of pH sensitive amphiphilic diblock copolymers where the associating block is a copolymer have been synthesized. Their pH sensitive behavior has been explored by a range of analytical techniques and the nanostructures formed are highly sensitive to both pH and the associating block composition.

Core–shell tecto dendrimers formed via host–guest supramolecular assembly as pH-responsive intelligent carriers for enhanced anticancer drug delivery

Nanoscale ◽  
2019 ◽  
Vol 11 (46) ◽  
pp. 22343-22350 ◽  
Author(s):  
Jianhong Wang ◽  
Du Li ◽  
Yu Fan ◽  
Menghan Shi ◽  
Yunxia Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Supramolecular Assembly ◽  
Anticancer Therapy ◽  
Ph Sensitive ◽  
Core Shell ◽  
Ph Responsive ◽  
Anticancer Drug Delivery

Core–shell tecto dendrimers can be prepared via host–guest supramolecular assembly for encapsulation and pH-sensitive release of drugs for an improved anticancer therapy.

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