scholarly journals Tuning the aggregation behavior of pH-responsive micelles by copolymerization

2015 ◽  
Vol 6 (14) ◽  
pp. 2761-2768 ◽  
Author(s):  
Daniel B. Wright ◽  
Joseph P. Patterson ◽  
Anaïs Pitto-Barry ◽  
Pepa Cotanda ◽  
Christophe Chassenieux ◽  
...  
Keyword(s):  
Diblock Copolymers ◽  
Analytical Techniques ◽  
Ph Sensitive ◽  
Aggregation Behavior ◽  
Ph Responsive ◽  
Highly Sensitive ◽  
Amphiphilic Diblock Copolymers ◽  
Sensitive Behavior

A series of pH sensitive amphiphilic diblock copolymers where the associating block is a copolymer have been synthesized. Their pH sensitive behavior has been explored by a range of analytical techniques and the nanostructures formed are highly sensitive to both pH and the associating block composition.

Aggregation behavior in water of amphiphilic diblock copolymers bearing biocompatible phosphorylcholine and cholesteryl groups

2014 ◽  
Vol 47 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Sayaka Ohno ◽  
Shoto Hasegawa ◽  
Huihua Liu ◽  
Kazuhiko Ishihara ◽  
Shin-ichi Yusa
Keyword(s):  
Diblock Copolymers ◽  
Aggregation Behavior ◽  
Amphiphilic Diblock Copolymers

pH-Responsive Micellization of Amphiphilic Diblock Copolymers Synthesized via Reversible Addition−Fragmentation Chain Transfer Polymerization

2003 ◽  
Vol 36 (11) ◽  
pp. 4208-4215 ◽  
Author(s):  
Shin-ichi Yusa ◽  
Yoshihiko Shimada ◽  
Yoshiro Mitsukami ◽  
Tohei Yamamoto ◽  
Yotaro Morishima
Keyword(s):  
Diblock Copolymers ◽  
Chain Transfer ◽  
Ph Responsive ◽  
Reversible Addition ◽  
Amphiphilic Diblock Copolymers ◽  
Chain Transfer Polymerization

scholarly journals Novel pH-Responsive Amphiphilic Diblock Copolymers with Reversible Micellization Properties

Langmuir ◽  
2003 ◽  
Vol 19 (12) ◽  
pp. 5175-5177 ◽  
Author(s):  
S. Dai ◽  
P. Ravi ◽  
K. C. Tam ◽  
B. W. Mao ◽  
L. H. Gan
Keyword(s):  
Diblock Copolymers ◽  
Ph Responsive ◽  
Amphiphilic Diblock Copolymers

scholarly journals Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1317 ◽  
Author(s):  
Sadaf Samimi Gharaie ◽  
Seyed Dabiri ◽  
Mohsen Akbari
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Total Solid ◽  
Shear Thinning ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Physiological Conditions ◽  
Optimum Formulation ◽  
Localized Drug Delivery ◽  
Sensitive Behavior

In this study, we fabricated and characterized a smart shear-thinning hydrogel composed of gelatin and laponite for localized drug delivery. We added chitosan (Chi) and poly N-isopropylacrylamide-co-Acrylic acid (PNIPAM) particles to the shear-thinning gel to render it pH-responsive. The effects of total solid weight and the percentage of laponite in a solid mass on the rheological behavior and mechanical properties were investigated to obtain the optimum formulation. The nanocomposite gel and particles were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), zeta potential, and dynamic light scattering techniques. Finally, release related experiment including degradability, swelling and Rhodamine B (Rd) release at various pH were performed. The results suggest that incorporation of silicate nanoplatelets in the gelatin led to the formation of the tunable porous composite, with a microstructure that was affected by introducing particles. Besides, the optimum formulation possessed shear-thinning properties with modified rheological and mechanical properties which preserved its mechanical properties while incubated in physiological conditions. The release related experiments showed that the shear-thinning materials offer pH-sensitive behavior so that the highest swelling ratio, degradation rate, and Rd release were obtained at pH 9.18. Therefore, this nanocomposite gel can be potentially used to develop pH-sensitive systems.

Controlled one-pot synthesis of pH-sensitive self-assembled diblock copolymers and their aggregation behavior

Polymer ◽  
2005 ◽  
Vol 46 (23) ◽  
pp. 10045-10055 ◽  
Author(s):  
B.W. Mao ◽  
L.H. Gan ◽  
Y.Y. Gan ◽  
K.C. Tam ◽  
O.K. Tan
Keyword(s):  
Diblock Copolymers ◽  
Ph Sensitive ◽  
Aggregation Behavior ◽  
One Pot ◽  
One Pot Synthesis ◽  
Self Assembled
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