scholarly journals Compressional Optical Coherence Elastography of the Cornea

Photonics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 111
Author(s):  
Manmohan Singh ◽  
Achuth Nair ◽  
Salavat R. Aglyamov ◽  
Kirill V. Larin
Keyword(s):  
Rabbit Model ◽  
Biomechanical Properties ◽  
Clinical Applications ◽  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Biomechanical Properties ◽  
Corneal Collagen

Assessing the biomechanical properties of the cornea is crucial for detecting the onset and progression of eye diseases. In this work, we demonstrate the application of compression-based optical coherence elastography (OCE) to measure the biomechanical properties of the cornea under various conditions, including validation in an in situ rabbit model and a demonstration of feasibility for in vivo measurements. Our results show a stark increase in the stiffness of the corneas as IOP was increased. Moreover, UV-A/riboflavin corneal collagen crosslinking (CXL) also dramatically increased the stiffness of the corneas. The results were consistent across 4 different scenarios (whole CXL in situ, partial CXL in situ, whole CXL in vivo, and partial CXL in vivo), emphasizing the reliability of compression OCE to measure corneal biomechanical properties and its potential for clinical applications.

scholarly journals Influence of dextran solution and corneal collagen crosslinking on Corneal Biomechanical Parameters Evaluated by Corvis ST

2021 ◽  
Author(s):  
Xiao Qin ◽  
Lei Tian ◽  
Hui Zhang ◽  
Di Zhang ◽  
Li-Li Guo ◽  
...  
Keyword(s):  
Biomechanical Properties ◽  
Control Group ◽  
Corvis St ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Biomechanical Parameters ◽  
Dextran Solution ◽  
Corneal Biomechanical Properties ◽  
Porcine Eyes ◽  
Corneal Collagen

Abstract Purpose: To analyze the influence of dextran solution and corneal collagen crosslinking (CXL) on corneal biomechanical parameters evaluated by Corneal Visualization Scheimpflug Technology (Corvis ST). Materials and Methods: Forty porcine eyes were included in this study. Twenty porcine eyes were soaked in dextran solution for 30 minutes (10 eyes in 2% dextran solution and 10 eyes in 20% dextran solution). CXL treatment was performed in 10 porcine eyes, the other 10 porcine eyes were regarded as a control group. Each eye was fixed on an experimental inflation platform to carry out Corvis measurements at different IOPs. Corneal biomechanical parameters were calculated based on Corvis measurement. Statistical analysis was used to analyze the influence of dextran solution and CXL on corneal biomechanical parameters based on Corvis parameters. Results: Corneal energy absorbed area (Aabsorbed) decreased after being soaked in dextran solution under IOP of 15 mmHg; Corneal elastic modulus (E) decreased after being soaked in 2% dextran solution and increased after being soaked in 20% dextran solution; SP-A1 increased after CXL. Conclusion: Both dextran solution and CXL can change corneal biomechanical properties; SP-A1 may be used as an effective parameter for the evaluation of CXL.

In Vivo Confocal Microscopy after Corneal Collagen Crosslinking

2015 ◽  
Vol 13 (4) ◽  
pp. 298-314 ◽  
Author(s):  
Cosimo Mazzotta ◽  
Farhad Hafezi ◽  
George Kymionis ◽  
Stefano Caragiuli ◽  
Soosan Jacob ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
In Vivo Confocal Microscopy ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

Transepithelial Corneal Collagen Crosslinking for Keratoconus: Qualitative Investigation by in vivo HRT II Confocal Analysis

2012 ◽  
Vol 22 (7_suppl) ◽  
pp. 81-88 ◽  
Author(s):  
Aldo Caporossi ◽  
Cosimo Mazzotta ◽  
Stefano Baiocchi ◽  
Tomaso Caporossi ◽  
Anna Lucia Paradiso
Keyword(s):  
Qualitative Investigation ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

scholarly journals Silicone Hydrogel Miniscleral Contact Lenses after Corneal Collagen Crosslinking for Post-LASIK Keratoectasia

2014 ◽  
Vol 3 (3) ◽  
pp. 127-129
Author(s):  
Boris Severinsky
Keyword(s):  
Contact Lens ◽  
Contact Lenses ◽  
Visual Outcome ◽  
Visual Rehabilitation ◽  
Collagen Crosslinking ◽  
Silicone Hydrogel ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

ABSTRACT Purpose To report successful visual rehabilitation of post refractive surgery keratoectasia shortly after corneal collage crosslinking (CXL) procedure achieved with silicone hydrogel mini-scleral (SHmS) contact lens. Materials and methods A 29-year-old woman attended to our clinic with complaints on decreased vision in her left eye. Twelve years earlier she underwent bilateral laser-assisted in situ keratomileusis (LASIK) procedure for myopia correction. Corneal topography revealed bilateral central keratoectasia with maximal keratometry values of 55.4 Diopter (D) for her right eye and 59.7 D for the left, corneal thicknesses were 422 and 443 respectively. The patient underwent an uneventful CXL procedure in her left eye and was fitted with SHmS lens 5 weeks later. The lens was designed to rest over the patients’ sclera and perilimbal cornea and vault the central cornea with minimal support over it. Results SHmS lens fitting resulted in significant subjective improvement in visual acuity (from 20/200, unaided to 20/25, contact lens corrected). The patient was able to wear the lens upto 10 hours a day with stable contact lens corrected vision. No contact lens related complications, such as edema or neovascularization were observed during 3 months follow-up period. As a result of successful restoration of vision in the CXL-treated eye, the patient was scheduled for the procedure in her other eye. Conclusion SHmS contact lens should be considered as an option for the visual rehabilitation of corneas shortly after collagen corneal crosslinking procedure. This novel contact lens modality made from flexible and highly gas permeable material minimizes contact lens influence on corneal recovery after CXL and provides an excellent visual outcome. How to cite this article Severinsky B. Silicone Hydrogel Mini-scleral Contact Lenses after Corneal Collagen Crosslinking for Post-LASIK Keratoectasia. Int J Kerat Ect Cor Dis 2014;3(3):127-129.

scholarly journals Optical coherence elastography for evaluating customized riboflavin/UV-A corneal collagen crosslinking

2017 ◽  
Vol 22 (9) ◽  
pp. 091504 ◽  
Author(s):  
Manmohan Singh ◽  
Jiasong Li ◽  
Srilatha Vantipalli ◽  
Zhaolong Han ◽  
Kirill V. Larin ◽  
...  
Keyword(s):  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen
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