Acoustic micro-tapping optical coherence elastography (AuT-OCE) to quantify biomechanical changes following corneal collagen crosslinking: Ex vivo study

2021 ◽  
Vol 150 (4) ◽  
pp. A166-A166
Author(s):  
Mitchell Kirby ◽  
Ivan Pelivanov ◽  
John Pitre ◽  
Ryan Wallace ◽  
Matthew O'Donnell ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Biomechanical Changes ◽  
Ex Vivo Study ◽  
Corneal Collagen

scholarly journals Nonlinear optical corneal collagen crosslinking of ex vivo rabbit eyes

2016 ◽  
Vol 42 (11) ◽  
pp. 1660-1665 ◽  
Author(s):  
Samantha M. Bradford ◽  
Donald J. Brown ◽  
Tibor Juhasz ◽  
Eric Mikula ◽  
James V. Jester
Keyword(s):  
Nonlinear Optical ◽  
Ex Vivo ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

scholarly journals Compressional Optical Coherence Elastography of the Cornea

Photonics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 111
Author(s):  
Manmohan Singh ◽  
Achuth Nair ◽  
Salavat R. Aglyamov ◽  
Kirill V. Larin
Keyword(s):  
Rabbit Model ◽  
Biomechanical Properties ◽  
Clinical Applications ◽  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Biomechanical Properties ◽  
Corneal Collagen

Assessing the biomechanical properties of the cornea is crucial for detecting the onset and progression of eye diseases. In this work, we demonstrate the application of compression-based optical coherence elastography (OCE) to measure the biomechanical properties of the cornea under various conditions, including validation in an in situ rabbit model and a demonstration of feasibility for in vivo measurements. Our results show a stark increase in the stiffness of the corneas as IOP was increased. Moreover, UV-A/riboflavin corneal collagen crosslinking (CXL) also dramatically increased the stiffness of the corneas. The results were consistent across 4 different scenarios (whole CXL in situ, partial CXL in situ, whole CXL in vivo, and partial CXL in vivo), emphasizing the reliability of compression OCE to measure corneal biomechanical properties and its potential for clinical applications.

scholarly journals Optical coherence elastography for evaluating customized riboflavin/UV-A corneal collagen crosslinking

2017 ◽  
Vol 22 (9) ◽  
pp. 091504 ◽  
Author(s):  
Manmohan Singh ◽  
Jiasong Li ◽  
Srilatha Vantipalli ◽  
Zhaolong Han ◽  
Kirill V. Larin ◽  
...  
Keyword(s):  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

scholarly journals Outcome of Corneal Collagen Crosslinking for Progressive Keratoconus in Paediatric Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Deepa Viswanathan ◽  
Nikhil L. Kumar ◽  
John J. Males
Keyword(s):  
Young Patients ◽  
Ultraviolet A ◽  
Effective Treatment Option ◽  
Collagen Crosslinking ◽  
Paediatric Patients ◽  
Corneal Grafting ◽  
Minimum Angle ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
Corneal Collagen

Purpose. To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients.Methods. This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min).Results. The mean patient age was 14.3 ± 2.4 years (range 8–17) and mean followup duration was 20.1 ± 14.25 months (range 6–48). Crosslinked eyes demonstrated a significant reduction of keratometry values. The mean baseline simulated keratometry values were 46.34 dioptres (D) in the flattest meridian and 50.06 D in the steepest meridian. At 20 months after crosslinking, the values were 45.67 D (P=0.03) and 49.34 D (P=0.005), respectively. The best spectacle corrected visual acuity (BSCVA) and topometric astigmatism improved after crosslinking. Mean logarithm of the minimum angle of resolution (logMAR) BSCVA decreased from 0.24 to 0.21 (P=0.89) and topometric astigmatism reduced from mean 3.50 D to 3.25 D (P=0.51).Conclusions. Collagen crosslinking using riboflavin and ultraviolet-A is an effective treatment option for progressive keratoconus in paediatric patients. Crosslinking stabilises the condition and, thus, reduces the need for corneal grafting in these young patients.

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