Optical Coherence Tomography and Confocal Microscopy Following Three Different Protocols of Corneal Collagen-Crosslinking in Keratoconus

2014 ◽  
Vol 55 (11) ◽  
pp. 7601 ◽  
Author(s):  
Nacim Bouheraoua ◽  
Lea Jouve ◽  
Mohamed El Sanharawi ◽  
Otman Sandali ◽  
Cyrille Temstet ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

In Vivo Confocal Microscopy after Corneal Collagen Crosslinking

2015 ◽  
Vol 13 (4) ◽  
pp. 298-314 ◽  
Author(s):  
Cosimo Mazzotta ◽  
Farhad Hafezi ◽  
George Kymionis ◽  
Stefano Caragiuli ◽  
Soosan Jacob ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
In Vivo Confocal Microscopy ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

scholarly journals Intraoperative Pachymetry Using Spectral-Domain Optical Coherence Tomography during Accelerated Corneal Collagen Crosslinking

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Vanissa W. S. Chow ◽  
Sayantan Biswas ◽  
Marco Yu ◽  
Victoria W. Y. Wong ◽  
Vishal Jhanji
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Ultrasound Pachymetry ◽  
Significant Difference ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen ◽  
Corneal Thinning

Purpose. To evaluate the role of spectral-domain optical coherence tomography (SDOCT) to measure corneal thickness during accelerated corneal crosslinking (CXL).Methods. Intraoperative pachymetry was performed using SDOCT and ultrasound pachymetry (USP) in 6 eyes of 6 patients with keratoconus. Pachymetry readings were obtained at baseline, after epithelium removal and after 30 minutes of riboflavin instillation. SDOCT measurements of eyes with and without lid speculum during riboflavin instillation were compared.Results. There was no statistically significant difference in central corneal thickness (CCT) measurements between SDOCT and USP (P>0.05for all). A significant decrease in both CCT (P=0.031) and the thinnest corneal thickness (TCT) (P=0.031) was observed during CXL. There was a greater reduction in CCT (38 ± 6%) with the use of lid speculum as compared to the no-speculum eyes (18 ± 9%) (P=0.100). TCT was also reduced by a greater extent with the use of lid speculum (40 ± 5% versus 26 ± 7%;P=0.100).Conclusion. SDOCT can be successfully used to measure intraoperative corneal pachymetry during corneal CXL. SDOCT measurements demonstrated corneal thinning intraoperatively during CXL, which was further accentuated by the use of a lid speculum during the procedure.

Correlation of the Corneal Collagen Cross-Linking Demarcation Line Using Confocal Microscopy and Anterior Segment Optical Coherence Tomography in Keratoconic Patients

2014 ◽  
Vol 157 (1) ◽  
pp. 110-115.e1 ◽  
Author(s):  
George D. Kymionis ◽  
Michael A. Grentzelos ◽  
Argyro D. Plaka ◽  
Konstantinos I. Tsoulnaras ◽  
Vasilios F. Diakonis ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Cross Linking ◽  
Optical Coherence ◽  
Demarcation Line ◽  
Collagen Cross Linking ◽  
Corneal Collagen

scholarly journals Compressional Optical Coherence Elastography of the Cornea

Photonics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 111
Author(s):  
Manmohan Singh ◽  
Achuth Nair ◽  
Salavat R. Aglyamov ◽  
Kirill V. Larin
Keyword(s):  
Rabbit Model ◽  
Biomechanical Properties ◽  
Clinical Applications ◽  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Biomechanical Properties ◽  
Corneal Collagen

Assessing the biomechanical properties of the cornea is crucial for detecting the onset and progression of eye diseases. In this work, we demonstrate the application of compression-based optical coherence elastography (OCE) to measure the biomechanical properties of the cornea under various conditions, including validation in an in situ rabbit model and a demonstration of feasibility for in vivo measurements. Our results show a stark increase in the stiffness of the corneas as IOP was increased. Moreover, UV-A/riboflavin corneal collagen crosslinking (CXL) also dramatically increased the stiffness of the corneas. The results were consistent across 4 different scenarios (whole CXL in situ, partial CXL in situ, whole CXL in vivo, and partial CXL in vivo), emphasizing the reliability of compression OCE to measure corneal biomechanical properties and its potential for clinical applications.

scholarly journals Optical coherence elastography for evaluating customized riboflavin/UV-A corneal collagen crosslinking

2017 ◽  
Vol 22 (9) ◽  
pp. 091504 ◽  
Author(s):  
Manmohan Singh ◽  
Jiasong Li ◽  
Srilatha Vantipalli ◽  
Zhaolong Han ◽  
Kirill V. Larin ◽  
...  
Keyword(s):  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen
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