Transepithelial Corneal Collagen Crosslinking for Keratoconus: Qualitative Investigation by in vivo HRT II Confocal Analysis

2012 ◽  
Vol 22 (7_suppl) ◽  
pp. 81-88 ◽  
Author(s):  
Aldo Caporossi ◽  
Cosimo Mazzotta ◽  
Stefano Baiocchi ◽  
Tomaso Caporossi ◽  
Anna Lucia Paradiso
Keyword(s):  
Qualitative Investigation ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

In Vivo Confocal Microscopy after Corneal Collagen Crosslinking

2015 ◽  
Vol 13 (4) ◽  
pp. 298-314 ◽  
Author(s):  
Cosimo Mazzotta ◽  
Farhad Hafezi ◽  
George Kymionis ◽  
Stefano Caragiuli ◽  
Soosan Jacob ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
In Vivo Confocal Microscopy ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

scholarly journals Compressional Optical Coherence Elastography of the Cornea

Photonics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 111
Author(s):  
Manmohan Singh ◽  
Achuth Nair ◽  
Salavat R. Aglyamov ◽  
Kirill V. Larin
Keyword(s):  
Rabbit Model ◽  
Biomechanical Properties ◽  
Clinical Applications ◽  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Biomechanical Properties ◽  
Corneal Collagen

Assessing the biomechanical properties of the cornea is crucial for detecting the onset and progression of eye diseases. In this work, we demonstrate the application of compression-based optical coherence elastography (OCE) to measure the biomechanical properties of the cornea under various conditions, including validation in an in situ rabbit model and a demonstration of feasibility for in vivo measurements. Our results show a stark increase in the stiffness of the corneas as IOP was increased. Moreover, UV-A/riboflavin corneal collagen crosslinking (CXL) also dramatically increased the stiffness of the corneas. The results were consistent across 4 different scenarios (whole CXL in situ, partial CXL in situ, whole CXL in vivo, and partial CXL in vivo), emphasizing the reliability of compression OCE to measure corneal biomechanical properties and its potential for clinical applications.

scholarly journals Outcome of Corneal Collagen Crosslinking for Progressive Keratoconus in Paediatric Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Deepa Viswanathan ◽  
Nikhil L. Kumar ◽  
John J. Males
Keyword(s):  
Young Patients ◽  
Ultraviolet A ◽  
Effective Treatment Option ◽  
Collagen Crosslinking ◽  
Paediatric Patients ◽  
Corneal Grafting ◽  
Minimum Angle ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
Corneal Collagen

Purpose. To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients.Methods. This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min).Results. The mean patient age was 14.3 ± 2.4 years (range 8–17) and mean followup duration was 20.1 ± 14.25 months (range 6–48). Crosslinked eyes demonstrated a significant reduction of keratometry values. The mean baseline simulated keratometry values were 46.34 dioptres (D) in the flattest meridian and 50.06 D in the steepest meridian. At 20 months after crosslinking, the values were 45.67 D (P=0.03) and 49.34 D (P=0.005), respectively. The best spectacle corrected visual acuity (BSCVA) and topometric astigmatism improved after crosslinking. Mean logarithm of the minimum angle of resolution (logMAR) BSCVA decreased from 0.24 to 0.21 (P=0.89) and topometric astigmatism reduced from mean 3.50 D to 3.25 D (P=0.51).Conclusions. Collagen crosslinking using riboflavin and ultraviolet-A is an effective treatment option for progressive keratoconus in paediatric patients. Crosslinking stabilises the condition and, thus, reduces the need for corneal grafting in these young patients.

scholarly journals Intrastromal corneal rings and corneal collagen crosslinking for progressive keratoconus: comparison of two sequences

Eye ◽  
2014 ◽  
Vol 29 (2) ◽  
pp. 294-295 ◽  
Author(s):  
N Saib ◽  
S Bonnel ◽  
J-R Fenolland ◽  
M Abrieu ◽  
C Rambaud ◽  
...  
Keyword(s):  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

Evaluation of changes in corneal biomechanics in eyes with keratectasia

2021 ◽  
pp. 179-187
Author(s):  
B.E. Malugin ◽  
◽  
E.G. Solodkova ◽  
S.V. Balalin ◽  
V.S. Kulikov ◽  
...  
Keyword(s):  
Corneal Thickness ◽  
Corneal Biomechanics ◽  
Corvis St ◽  
Collagen Crosslinking ◽  
The Third ◽  
Corneal Rigidity ◽  
Corneal Collagen Crosslinking ◽  
Early Features ◽  
Healthy Persons ◽  
Corneal Collagen

Purpose. To make a comparative analysis of topographic, tomographic and biomechanical values, measured by Pentacam HR and Corvis ST, in healthy multirefractive cohort versus patients with keratectasia of various severity. Material and methods. The prospective study comprised 237 patients aged from 18 to 47 years, subdivided into three groups. The first group included 174 healthy persons with various refraction (174 eyes). The second and the third group embraced 63 patients with keratoconus: 36 patients (36 eyes) with keratoconus of the I degree and 27 eyes with keratoconus of the II and III degrees. Besides the conventional comprehensive ocular examination the following studies were performed in all the patients: evaluation of topographic, tomographic and biomechanical corneal properties with application of Pentacam HR and Corvis ST (OCULUS Optikgerate GmbH; Wetzlar, Germany). Results. It was revealed that the following biomechanical values, assessed by means of Pentacam HR and Corvis ST, exhibited statistically significant changes (p<0,001) in all degrees of ketatoconus: a relative corneal thickness by Ambrosio, inverted radius of applanation curvature (IntRadius), DA Ratio Coefficient, values of corneal rigidity – SP-A 1 and SSI. Conclusion. The detected parameters may be applied as indicators, allowing to evaluate corneal biomechanics, to define early features of ectatic process, to assess effectiveness of the performed corneal collagen crosslinking and intralamellar keratoplasty with implantation of corneal segments. Key words: keratoconus, corneal biomechanics, pachymetry, index of pachymetric progression, corneal viscoelasticity.

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