scholarly journals Zinc Nutritional Status in a Series of Children with Chronic Diseases: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1121
Author(s):  
Marlene Fabiola Escobedo-Monge ◽  
María Carmen Torres-Hinojal ◽  
Enrique Barrado ◽  
María Antonieta Escobedo-Monge ◽  
José Manuel Marugán-Miguelsanz
Keyword(s):  
Nutritional Status ◽  
Chronic Diseases ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Normal Growth ◽  
Dietary Reference Intake ◽  
Human Beings ◽  
Dietary Zinc ◽  
Cross Sectional ◽  
Zinc Intake

Background: Zinc is an essential trace element for the normal growth and development of human beings. The main objective was to evaluate the nutritional status of zinc and its association with nutritional indicators in a series of children with chronic diseases. Methods: The prevalence of patients with dietary zinc deficiency or deficit zinc intake (<80% DRI: dietary reference intake) was analyzed through prospective 72 h dietary surveys, and serum zinc deficiency or hypozincemia (≤70 µg/dL in children under 10 years of age in both sexes and in females older than 10 years and <74 μg/dL in males older than 10 years) was measured through atomic absorption spectrophotometry. The participants were classified according to their nutritional status by body mass index (BMI). Results: Mean serum zinc level in obese (87 µg/dL), undernourished (85 µg/dL), and eutrophic children (88 µg/dL) were normal, but in the undernutrition (60% DRI) and eutrophic (67% DRI) groups the mean dietary zinc intake was low compared to that in the obesity group (81% DRI). There were different associations between nutritional parameters, dietary zinc intake, and serum zinc. All patients with hypozincemia had dietary zinc deficiency. Conclusions: In the whole series, 69% of participants showed a zinc intake lower than recommended and might be at high risk of zinc deficiency.

scholarly journals Zinc Nutritional Status in Patients with Cystic Fibrosis

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 150 ◽  
Author(s):  
Marlene Fabiola Escobedo Monge ◽  
Enrique Barrado ◽  
Carmen Alonso Vicente ◽  
María Paz Redondo del Río ◽  
José Manuel Marugán de Miguelsanz
Keyword(s):  
Cystic Fibrosis ◽  
Nutritional Status ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Dietary Reference Intake ◽  
Human Beings ◽  
Z Score ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Marginal Zinc Deficiency

Background: Zinc is an essential nutrient for all forms of life and its deficiency affects the normal growth and development of human beings. Objective: The main aim was to investigate zinc nutritional status by serum zinc concentration (SZC) and dietary zinc intake and their association in cystic fibrosis (CF) patients. Methods: A cross-sectional study was conducted in CF patients. Anthropometric measurements and respiratory and pancreatic tests were conducted. Hypozincemia was determined by SZC while using atomic absorption spectrophotometry and dietary zinc deficiency by prospective 72-h dietary surveys. Results: Mean SZC (87.2 ± 16.7 μg/dL) and dietary zinc intake (97 ± 26.9% Dietary Reference Intake) were normal. Three of 17 patients with CF (17.6%) had hypozincemia and four (23.5%) had a dietary zinc deficiency. No patient with dietary zinc deficiency had hypozincemia. A positive and significant association was observed between SZC and Z-score of BMI-for-age (p = 0.048) and weight-for-height (p = 0.012) and between dietary zinc intake and energy intake (EI, p = 0.036) and Z-score of weight-for-high (p = 0.029). Conclusion: SZC was associated with the nutritional status, expressed as BMI (Body Mass Index) and weight-for-height Z score, and dietary zinc intake with EI and weight-for-height Z-score. No patient with hypozincemia had dietary zinc deficiency. This situation should alert us to a marginal zinc deficiency and it may explain why there were no overlapping cases between the two groups. We suggest that probably 41% of the cases in this study would be at elevated risk of zinc deficiency and a zinc supplementation may be considered.

scholarly journals Correlation of Dietary Zinc Intake and Serum Zinc with Thyroid Stimulating Hormone (TSH) and Free Thyroxine (FT4) Levels in Adult Hyperthyroid Patients

2021 ◽  
Vol 5 (3) ◽  
pp. 341
Author(s):  
Utami Harjantini ◽  
Diffah Hanim ◽  
Yulia Lanti Retno Dewi ◽  
Ida Nurwati
Keyword(s):  
Serum Zinc ◽  
Food Composition ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Thyroid Disorder ◽  
Dietary Zinc ◽  
Cross Sectional ◽  
Zinc Intake ◽  
Hyperthyroid Patients ◽  
Stimulating Hormone

Background: Hyperthyroidism is a thyroid disorder caused by increased synthesis and secretion of thyroid hormone by the thyroid gland. Hyperthyroidism is characterized by low thyroid stimulating hormone (TSH) and high free thyroxine (FT4) levels. The prevalence of hyperthyroidism in Indonesia was 0.6% in female and 0.2% in male. Zinc acts as an enzyme cofactor that converts thyroxine into triiodothyronine and it affects TSH synthesis. Adequacy of dietary zinc intake and serum zinc levels in hyperthyroid patients indirectly affects TSH and FT4 hormones.Objective: to analyze the correlation of dietary zinc intake and serum zinc with TSH and FT4 levels in adult hyperthyroid patients.Materials and Methods: This cross sectional study sampling based on inclusion and exclusion criteria which obtained 50 adult hyperthyroid patients at the Clinic of the Magelang Health Research and Development Center. Data of TSH and FT4 levels were measured by the ELISA method, serum zinc was measured with the ICP-MS method, dietary zinc intake’s data was collected using the 24 hour dietary recall and it was analyzed based on the table of Indonesian food composition 2017. Statistical analysis used in this study were spearman correlation and multivariate linear regression with 95% confidence level.Results : Dietary zinc intake did not correlate with both TSH and FT4 levels (p>0.05). Serum zinc had no correlation with TSH level (p>0.05), while serum zinc had a positive correlation with FT4 level (r=0.327; β=0.054; p<0.05).Conclusion: Serum zinc concentrations in adult hyperthyroid patients must be maintained because abnormal zinc status in the body’s metabolism will affect FT4 level.International Journal of Human and Health Sciences Vol. 05 No. 03 July’21 Page: 341-346

Serum Zinc Levels in Cirrhotic Patients Attending General and Specialty Hospitals, Yangon

2019 ◽  
Vol 31 (3) ◽  
pp. 251-256
Keyword(s):  
Clinical Practice ◽  
Hepatic Encephalopathy ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Zinc Level ◽  
The Body ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Cirrhotic Patients ◽  
Cirrhosis Of Liver

Cirrhosis of liver is one of the common medical problem in daily clinical practice and one of the leading causes of morbidity and mortality. Zinc is an essential trace elements for human and plays in many biological roles in the body. Among them, zinc deficiency is thought to be involved in metabolism of ammonia and causes hyperammonia that worsen hepatic encephalopathy. This study aimed to find out the severity of cirrhosis of liver was by Child Turcotte Pugh score and to investigate the associations between serum zinc level and severity of cirrhosis. A hospital-based cross-sectional descriptive study was performed on 78 patients with different underlying causes of cirrhosis of liver at the Medical Units of Yangon General Hospital and Yangon Specialty Hospital. Among the study population, Child grade A was found to be 28.21%, Child grade B was 30.77% and Child grade C was 41.03%. Regarding result of serum zinc level, 62.8% were low level, 28.2% were within normal level and 8.9% were high level. Mean value of serum zinc level in grade A was 0.68 mg/l, grade B was 0.54 mg/l and grade C was 0.48 mg/l (p=0.00). It was found out that there was a high prevalence of zinc deficiency in severe cirrhotic patients. The zinc level was significantly lowest among patients with Child-Pugh C as compare to those with Child-Pugh B and C. Severity of zinc deficiency should be requested for supplementation therapy in cirrhotic patients as to prevent complications such as hepatic encephalopathy, hepatocellular carcinoma and liver failure. Screening for zinc deficiency may need in these patients with more advanced cirrhosis because it seems to be a marker of advanced liver disease and it can be deducted that awareness of serum zinc level among cirrhotic patients is very important in clinical practice.

scholarly journals Prevalence of zinc deficiency among primary school children in a poor peri-urban informal settlement in South Africa

2010 ◽  
Vol 15 (1) ◽  
Author(s):  
Folake O. Samuel ◽  
Abdulkadir A. Egal ◽  
Wilna H. Oldewage-Theron ◽  
Carin E. Napier ◽  
Christine S. Venter
Keyword(s):  
Social Sciences ◽  
South Africa ◽  
Zinc Deficiency ◽  
Informal Settlement ◽  
Serum Zinc ◽  
Primary School Children ◽  
World Health ◽  
Food Sources ◽  
Cross Sectional ◽  
The Mean

This cross-sectional study assessed the risk of zinc deficiency in randomly selected children, aged between 7 and 11 years, living in a poor, peri-urban informal settlement in South Africa. Dietary intake of 149 respondents was evaluated by 24-hour recall and quantitative food frequency questionnaires. Anthropometric and biochemical indices of a subset of 113 were determined. Descriptive statistics, analysis of variance and Pearson correlations were computed using the Statistical Package for Social Sciences, version 14.0. Anthropometric data were analysed using the World Health Organization Anthro plus version 1.0.2 statistical software. Dietary data were analysed with FoodFinder® version 3. The mean age of the children was 9.0±1.1 years. Few zinc-rich sources appeared in the diet that was predominantly plant-based. Mean dietary zinc intake was 4.6±2.2 mg/day. The mean value of serum zinc was 66.4±21.5 µg/dL, with 46% of the children having values less than the 70 µg/dL cut-off. The findings indicate a high risk of zinc deficiency and suboptimal zinc status for the majority of this study population of children, possibly as a result of low consumption of food sources with high bioavailability of zinc, which invariably is a direct consequence of poverty and food insecurity.OpsommingDie doel van hierdie dwarsdeursnitstudie was die bepaling van die risiko van ’n sinktekort in ’n ewekansige steekproef van 7 tot 11 jaar-oue kinders, woonagtig in ’n arm, voorstedelike informele woonbuurt in Suid Afrika. Dieetinnames van 149 respondente is geëvalueer deur 24-uur herroep en kwantitatiewe voedselfrekwensie vraelyste. Antropometriese en biochemiese indikatore van ’n kleiner steekproef van 113 is ook bepaal. Beskrywende statistiek, analise van variansie en Pearsonkorrelasies is bepaal deur die Statistical Package for Social Sciences, uitgawe 14.0. Antropometriese data is geanaliseer deur die statistiese program, Anthro plus, uitgawe 1.0.2, van die Wêreld Gesondheid Organisasie. Dieetdata is met behulp van FoodFinder® uitgawe 3 geanaliseer. Die gemiddelde ouderdom van die kinders was 9.0±1.1 jaar. Min sinkryke voedselbronne is in die hoofsaaklik plantryke dieet waargeneem. Die gemiddelde sinkinname was 4.6±2.2 mg/dag en die gemiddelde serumsinkwaarde was 66.4±21.5 µg/dL, met 46% van die kinders se waardes onder die 70 µg/dL afsnypunt. Die bevindings dui op ’n hoë risiko vir sinktekort en suboptimale sinkstatus vir die meerderheid van hierdie kinders, moontlik as gevolg van die swak inname van voedselbronne met hoë biobeskikbare sink, wat gewoonlik ’n direkte gevolg van armoede en huishoudelike voedsel insekuriteit is.

scholarly journals Nutritional status among children aged one to six years in tribal area

2020 ◽  
Vol 7 (7) ◽  
pp. 2715
Author(s):  
Palle Lokhnath Reddy ◽  
Aluka Anand Chand
Keyword(s):  
Nutritional Status ◽  
Normal Growth ◽  
Good Health ◽  
World Health ◽  
Microsoft Excel ◽  
Cross Sectional ◽  
Tribal Area ◽  
South Indian ◽  
Health Organization ◽  
Severe Degree

Background: Nutrition in children is considered as a major concern for good health and also for normal growth and development. The present study aimed to estimate the prevalence of malnutrition in 1 to 6 years children.Methods: This was a community based cross sectional carried out in a south Indian tribal area for a period of 5 years among 1020 children. The anthropometric measurements categorization among children was done using world health organization (WHO) guidelines. Data was analyzed using microsoft excel 2010.Results: Out of 1020 children, nutritional status based on underweight, stunting and wasting was 30.80%, 26.8% and 15.68% respectively. Severe degree of underweight, stunting and wasting was observed in 76.4%, 64.7% and 5.49% respectively.Conclusions: Under nutrition was significantly high in infants and it decreased with increasing in age and significantly higher number of female children were stunted and underweight compared to male children.

scholarly journals Copper and Copper/Zinc Ratio in a Series of Cystic Fibrosis Patients

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3344
Author(s):  
Marlene Fabiola Escobedo-Monge ◽  
Enrique Barrado ◽  
Carmen Alonso Vicente ◽  
María Antonieta Escobedo-Monge ◽  
María Carmen Torres-Hinojal ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Zinc Deficiency ◽  
Linear Regression Analysis ◽  
Bone Conduction ◽  
Serum Zinc ◽  
Abdominal Ultrasound ◽  
Serum Copper ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Copper Zinc

Cystic fibrosis (CF) patients require a stable and sufficient supply of micronutrients. Since copper is an essential micronutrient for human development, a cross-sectional study was carried out to investigate the serum copper levels, serum copper/zinc (Cu/Zn) ratios, and their relationship with nutritional indicators in a group of CF patients. Anthropometric, biochemical, and dietary measurements, an abdominal ultrasound, and respiratory and pancreatic tests were conducted. Seventeen CF patients were studied (10 females, 59%), 76.5% of whom were ∆F580. Their mean serum copper (113 ± 23 μg/dL) was normal, and there was only one teenager with hypocupremia (6%) and two children with hypercupremia (18%). A significant association between serum copper and zinc levels was discovered. The Cu/Zn ratio was higher than 1.00 for 94% of patients, which is an indicator of an inflammation status. There was no significant correlation between the serum copper concentrations and respiratory and pancreatic function, respiratory colonization, and the results of the abdominal ultrasound. Linear regression analysis showed that serum copper had a positive association with both the Z-score body mass index (BMI) and mean bone conduction speed (BCS). Therefore, since 94% of CF patients had a Cu/Zn ratio > 1.00, this factor must alert us to consider the risk of zinc deficiency and high inflammatory response. The measurement of serum zinc alone does not show one’s zinc status. However, the Cu/Zn ratio may be an indicator of zinc deficiency and the inflammatory status of CF patients.

scholarly journals The effect of dietary zinc deficiency on pancreatic γ-glutamyl hydrolase (EC3.4.22.12) activity and on the absorption of pteroylpolyglutamate in rats

1989 ◽  
Vol 62 (1) ◽  
pp. 185-193 ◽  
Author(s):  
Mary C. Canton ◽  
B. M. Cotter ◽  
F. M. Cremin ◽  
P. A. Morrissey
Keyword(s):  
Zinc Deficiency ◽  
Pancreatic Enzyme ◽  
Hydrolase Activity ◽  
Zn Deficiency ◽  
Human Beings ◽  
Dietary Zinc ◽  
Deficient Diet ◽  
Adequate Diet ◽  
Plasma Folate ◽  
Male Wistar Rats

The effect of dietary zinc deficiency on γ-glutamyl hydrolase (EC3.4.22.12) activity and on pteroylpolyglutamate absorption was investigated in rats. Enzyme activity was determined in pancreas and gut lumen washings. Pteroylpolyglutamate absorption was studied by determining the rise in plasma folate levels following pteroylpolyglutamate ingestion. Two experiments were performed; in each purified diets were given to three groups of immature male Wistar rats for approximately 2 weeks. One group was given a Zn-deficient dietad lib.(ZD), the second was pair-fed daily with this group on a Zn-adequate diet (PF) and the third was given the Zn-adequate dietad lib.(AL). In Expt 1, significantly reduced pancreatic γ-glutamyl hydrolase activity was observed in ZD rats. In Expt 2, pteroylpolyglutamate was administered on day 14 and in the 3 h period following pteroylpolyglutamate ingestion, lumen γ-glutamyl hydrolase activity and plasma folate levels were significantly lower in ZD rats. Pancreas is reported as the source of lumen γ-glutamyl hydrolase in rats. The results presented indicate that the pancreatic enzyme is Zn-sensitive. It was concluded that, as a result, γ-glutamyl hydrolase activity was reduced in the lumen of ZD rats. Consequently the hydrolysis and subsequent absorption of pteroylpolyglutamate was impaired in ZD rats, as indicated by the smaller rise in plasma folate levels that occurred following pteroylpolyglutamate ingestion. Results of this study concur with previous observations in human beings and rats that Zn deficiency has an adverse effect on folate metabolism.

Dietary Zinc Intake and Plasma Zinc Concentrations in Children with Short Stature and Failure to Thrive

2016 ◽  
Vol 69 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Nadine Yazbeck ◽  
Rima Hanna-Wakim ◽  
Rym El Rafei ◽  
Abir Barhoumi ◽  
Chantal Farra ◽  
...  
Keyword(s):  
Short Stature ◽  
Zinc Deficiency ◽  
Growth Parameters ◽  
Medical Center ◽  
Failure To Thrive ◽  
Plasma Zinc ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Significant Difference ◽  
Zinc Concentrations

Background: The burden of zinc deficiency on children includes an increased incidence of diarrhea, failure to thrive (FTT) and short stature. The aim of this study was to assess whether children with FTT and/or short stature have lower dietary zinc intake and plasma zinc concentrations compared to controls. Methods: A case-control study conducted at the American University of Beirut Medical Center included 161 subjects from 1 to 10 years of age. Results: Cases had a statistically significant lower energy intake (960.9 vs. 1,135.2 kcal for controls, p = 0.010), lower level of fat (30.3 vs. 36.5 g/day, p = 0.0043) and iron intake (7.4 vs. 9.1 mg/day, p = 0.034). There was no difference in zinc, copper, carbohydrate and protein intake between the 2 groups. The plasma zinc concentration did not differ between the cases and controls (97.4 vs. 98.2 μg/dl, p = 0.882). More cases had mild-to-moderate zinc deficiency when compared to controls with 10.3 vs. 3.6%, p = 0.095. Conclusion: Our study did not show statistically significant difference in dietary zinc intake and plasma zinc concentrations between children with FTT and/or short stature compared to healthy controls. A prospective study is planned to assess the effect of zinc supplementation on growth parameters in FTT children.

Changes in Serum Zinc Levels Associated with Giardiasis and Dietary Zinc Intake in Mice

2011 ◽  
Vol 145 (3) ◽  
pp. 396-402 ◽  
Author(s):  
Luis Quihui-Cota ◽  
Rosa Olivia Méndez Estrada ◽  
Humberto Astiazarán-García ◽  
Gloria Guadalupe Morales-Figueroa ◽  
Mario Jesús Moreno-Reyes ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Zinc Intake, Zinc Serum Levels, and Intelligence in School Children in Rural Areas

2021 ◽  
Vol 9 (E) ◽  
pp. 394-397
Author(s):  
Rostika Flora ◽  
Nur Alam Fajar ◽  
Fatmalina Febri ◽  
Indah Yuliana ◽  
Yuliarti Yuliarti ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
School Children ◽  
Significant Relationship ◽  
Rural Areas ◽  
Serum Zinc ◽  
Zinc Intake ◽  
Serum Zn ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

BACKGROUND: Children in rural areas are susceptible to zinc deficiency. Zinc deficiency in children can affect cognitive function in children. Zinc plays a role in cellular function and critical brain growth processes, including cell replication, DNA and RNA synthesis, and the release of neurotransmitters. AIM: This study aimed to analyze the condition of zinc deficiency and its relationship with the level of intelligence in children in rural areas. METHODS: The study design was cross-sectional, with a sample of 44 elementary school children aged 9–12 years taken randomly. Blood was drawn to measure serum Zn-levels, and serum Zn-levels were measured using Colorimetric Assay Kit (E-BC-K137). Zinc intake data were obtained from the food recall form, which was carried out 3 × 24 h. The level of intelligence is measured by the Culture Fair Intelligence Test method. The sample characteristics data obtained through a questionnaire. Furthermore, the data were analyzed using the Chi-square test. RESULTS: About 84.2% of children with insufficient zinc intake had low serum Zn-levels. There was a significant relationship between zinc intake and serum zinc levels (p = 0.026; PR = 4.293). Children with low serum zinc levels of 96.5% have intelligence levels below average. There was a significant relationship between serum zinc levels and intelligence level as well (p = 0.001; PR = 24,500). CONCLUSION: Zinc deficiency in children is characterized by low serum Zn-levels. Low serum Zn-level is caused by low zinc intake, thus children with low serum Zn-levels are at risk of having intelligence level below average. Therefore, health education about the importance of zinc intake in children should be given to parents, so that the incidence of zinc deficiency in children can be reduced.

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