scholarly journals Carnitine Serum Levels in Frail Older Subjects

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3887
Author(s):  
Giulia Malaguarnera ◽  
Vito Emanuele Catania ◽  
Claudia Bonfiglio ◽  
Gaetano Bertino ◽  
Enzo Vicari ◽  
...  
Keyword(s):  
Frail Elderly ◽  
Cognitive Activity ◽  
Free Carnitine ◽  
Favorable Effect ◽  
Elderly Subjects ◽  
Serum Concentrations ◽  
Frailty Status ◽  
Urine Concentrations ◽  
The Mean ◽  
Older Subjects

Frailty is an expression that reconciles and condenses loss of autonomy, both physical and cognitive decline and a wide spectrum of adverse outcomes due to aging. The decrease in physical and cognitive activity is associated with altered mitochondrial function, and energy loss and consequently morbidity and mortality. In this cross-sectional study, we evaluated the carnitine levels in frailty status. The mean serum concentrations of total carnitine (TC) were lower in frail elderly subjects than in prefrail ones (p = 0.0006), higher in frail vs. robust subjects (p < 0.0001), and higher in prefrail vs. robust subjects (p < 0.0001). The mean serum concentrations of free carnitine (FC) were lower in frail elderly subjects than in prefrail ones (p < 0.0001), lower in frail vs. robust subjects (p < 0.0001) and lower in prefrail vs. robust subjects (p = 0.0009). The mean serum concentrations of acylcarnitine (AC) were higher in frail elderly subjects than in prefrail ones (p = 0.054) and were higher in pre-frail vs. robust subjects (p = 0.0022). The mean urine concentrations of TC were lower in frail elderly subjects than in prefrail ones (p < 0.05) and lower in frail vs. robust subjects (p < 0.0001). The mean urine concentrations of free carnitine were lower in frail elderly vs. robust subjects (p < 0.05). The mean urine concentrations of acyl carnitines were lower in frail elderly subjects than those in both prefrail (p < 0.0001) and robust subjects (p < 0.0001). Conclusion: high levels of carnitine may have a favorable effect on the functional status and may treat the frailty status in older subjects.

CONJUGATION OF ANDROSTERONE IN YOUNG AND OLD SUBJECTS

1964 ◽  
Vol 46 (2) ◽  
pp. 170-178 ◽  
Author(s):  
Michael T. Ryan
Keyword(s):  
Large Dose ◽  
Elderly Subjects ◽  
Older Subjects

ABSTRACT In view of the decrease in excretion of total and individual 17-keto-steroids which occurs in elderly subjects, a comparison was made of the ability of the conjugating systems of young and old subjects to metabolize a moderately large dose of androsterone. Poor recoveries of administered androsterone, excreted into the urine, were observed in many of the older subjects and the change observed in the distribution of 17-ketosteroids between glucuronide and sulphate fractions seems to be related to level of steroid recovered in the urine rather than to age of the subjects.

scholarly journals Systolic blood pressure of dogs at hospital and domestic environment

2012 ◽  
Vol 42 (7) ◽  
pp. 1242-1248
Author(s):  
Frederico Aécio Carvalho Soares ◽  
Elisa Barp Neuwald ◽  
Verônica Santos Mombach ◽  
Ana Elize Ribeiro D'Avila ◽  
Francisco de Oliveira Conrado ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Doppler Ultrasonography ◽  
Serum Cortisol ◽  
Serum Concentrations ◽  
Pathological Conditions ◽  
Healthy Dogs ◽  
The Mean ◽  
Veterinary Hospital ◽  
At Home

The measurement of blood pressure (BP) is an important assessment of the cardiovascular system, being influenced by physical and pathological conditions. Certain situations of stress and anxiety during BP measurement can lead to elevated values in small animals, known in medicine as "white coat effect". The aim of this research was to compare systolic blood pressure (SBP) measurement using Doppler ultrasonography in 45 adult healthy dogs in two environments, at a veterinary hospital and at home. Comparison of heart rate, serum concentrations of cortisol and glucose intended to help the evaluation of the stress level of the animals. The mean of SBP at the veterinary hospital was 154.7mmHg and it was significantly (P<0.01) higher than at home (136.3mmHg). It was also observed that HR (mean=122.7bpm), and serum cortisol (median=4.5µg dL-1) and glucose (mean=95.9mg dL-1) concentrations were significantly higher (P<0.01) at the hospital, when compared with values obtained at home (109.6bpm; 1.5µg dL-1 and 85.5mg dL-1, respectively). In conclusion, the environment can influence SBP in dogs, due to factors related to stress.

scholarly journals Effects of medetomidine and atipamezole on serum glucose and cortisol levels in captive reindeer (Rangifer tarandus tarandus)

Rangifer ◽  
1999 ◽  
Vol 19 (2) ◽  
pp. 85 ◽  
Author(s):  
Jon M. Arnemo ◽  
Birgit Ranheim
Keyword(s):  
Rangifer Tarandus ◽  
Fold Increase ◽  
Serum Glucose ◽  
Serum Concentrations ◽  
Seasonal Differences ◽  
Blood Concentrations ◽  
Rangifer Tarandus Tarandus ◽  
Adrenoceptor Agonists ◽  
The Mean ◽  
Baseline Levels

<p>Serum concentrations of glucose and Cortisol were measured in five adult captive reindeer (Rangifer tarandus tarandus) at 24 h and 10 min before, and at 0.5, 1,2,4, 8, 12 and 24 h after, treatment with 60 p.g/kg of medetomidine i.v. followed by 300 jig/kg of atipamezole i.v. 60 min later. The experiments were performed in January and repeated in July-August. The animals were used as their own controls and treated with saline in July-August. The wash-out period between experiments in summer was 2 weeks or more. No obvious seasonal differences were observed. Mederomidine induced a 2.5-fold increase in glucose (mean &plusmn; standard error of the mean being 15.4 &plusmn; 0.6 mmol/1 at 1 h) and a 3.5-fold increase Cortisol (349 &plusmn; 28 nmol/1 at 0.5 h). Serum glucose reached control levels within 12 h, and Cortisol declined to baseline levels within 4 h after injection og medetomidine. The use of blood concentrations of glucose and Cortisol to assess nutritonal status, body condition and stress may be significantly biased in animals chemically immobilized with medetomidine or other alpha-2 adrenoceptor agonists.</p>

scholarly journals Circulating concentrations of insulin like growth factor-1 in female dogs with spontane-ous mammary tumours

2018 ◽  
Vol 74 (1) ◽  
pp. 6054-2018
Author(s):  
MAREK SZCZUBIAŁ ◽  
ROMAN DABROWSKI ◽  
WOJCIECH ŁOPUSZYŃSKI ◽  
MARIOLA BOCHNIARZ ◽  
MAGDALENA KRAWCZYK ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Cell Differentiation ◽  
Growth Factor ◽  
Healthy Controls ◽  
Serum Concentrations ◽  
Elisa Kit ◽  
Mammary Tumours ◽  
The Mean ◽  
Grade 3 ◽  
Mean Concentration

The aim of this study was the investigation of the circulating concentration of IGF-1 in female dogs with spontaneous mammary tumours. The study was performed on 34 female dogs undergoing surgery due to spontaneously occurring mammary gland tumours (24 malignant and 10 benign) and 10 clinically healthy fe-male dogs. The serum concentrations of IGF-1 were determined by specific ELISA Kit assay. The mean con-centrations of IGF-1 were significantly higher (P < 0.05) both in dogs with malignant (173.35 ± 120.45 ng/ml) and benign (130.58 ± 59.0 ng/ml) mammary tumours than in healthy controls (117.45±71.0 ng/ml). In the group of female dogs with mammary carcinomas, the mean concentration of IGF-1 gradually increased from 132.85 ± 65.64 ng/ml in dogs with grade 1 tumours to 317.74 ± 119.25 ng/ml in those with grade 3 tumours, and significant differences (P < 0.05) were found among dogs with various grade tumours. These findings suggest that circulating IGF-1 may play an important role in the pathogenesis of canine mammary tumour. Moreover, high IGF-1 levels may reflect tumour cell differentiation into a more aggressive phenotype. .

Vancomycin Serum Protein Binding Determination by Ultrafiltration

1988 ◽  
Vol 22 (4) ◽  
pp. 300-303 ◽  
Author(s):  
Bruce H. Ackerman ◽  
E. Howard Taylor ◽  
Keith M. Olsen ◽  
Wedad Abdel-Malak ◽  
Alexandras A. Pappas
Keyword(s):  
Protein Binding ◽  
Correlation Coefficient ◽  
Pharmacokinetic Study ◽  
Room Temperature ◽  
Total Serum ◽  
Serum Protein Binding ◽  
Serum Concentrations ◽  
Orthogonal Regression ◽  
The Mean ◽  
Serum Vancomycin

Sixty-two serum concentrations were obtained from 12 infected patients enrolled in a vancomycin pharmacokinetic study. Both unbound and total serum vancomycin concentrations were measured using ultrafiltration and a commercial fluorescent polarization immunoassay. Ultrafiltrates were obtained by centrifugation at 1000 × g for ten minutes at room temperature and their assay indicated a range in protein binding from 7.9 to 71 percent. The mean protein binding (mean ±SD) was 41.95 ± 14.15 percent. No measurable adsorption of vancomycin onto the ultrafiltration membrane was noted. Orthogonal regression of unbound versus total vancomycin concentrations was described by the equation y=0.597x-0.362 with a correlation coefficient of 0.948.

scholarly journals Evaluation of Plasma Amino Acid Levels in Preterm Infants and Their Potential Correlation with Retinopathy of Prematurity

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yasin Ozcan ◽  
Gumus Huseyin ◽  
Kenan Sonmez
Keyword(s):  
Amino Acids ◽  
Aspartic Acid ◽  
Preterm Infants ◽  
Retinopathy Of Prematurity ◽  
Glutamine Supplementation ◽  
Controlled Study ◽  
Serum Concentrations ◽  
Group A ◽  
The Mean ◽  
Group B

Aim. The aim of this study is to ascertain whether the level of circulating amino acids (aa) is associated with retinopathy of prematurity (ROP). Methods. This is a randomized controlled study of 55 infants born at gestational age (GA) ≤32 weeks or birth weight (BW) ≤1500 grams. Serum samples were obtained from two groups: Group A comprised of 26 preterm infants with ROP and Group B comprised of 29 preterm infants without ROP. Plasma aa levels were analyzed using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Correlation test and multivariate regression analysis were used to evaluate the relationship between plasma aa levels and variables. Results. The mean serum arginine and glutamine levels were significantly higher, but the mean lysine and aspartic acid levels were significantly lower in Group A, compared to Group B ( p = 0.04 , p = 0.002 , p = 0.029 , and p = 0.002 , respectively). In multivariate analysis, the mean arginine and lysine levels were significantly associated with the stage of the disease ( p = 0.03 and p = 0.01 , respectively). No significant differences were determined between the groups in terms of alanine, asparagine, valine, leucine, phenylalanine, tyrosine, serine, proline, citrulline, cysteine, ornithine, tryptophan, methionine, threonine, taurine, and isoleucine amino acids ( p > 0.05 , respectively). Conclusions. These results indicate a significant association between high arginine and glutamine, with low lysine and aspartic acid serum concentrations with ROP. Due to higher serum concentrations in ROP, extra arginine-glutamine supplementation in hyperoxic conditions may be unfavorable through pathways involving reactive oxygen, particularly in patients with ROP.

Geographic determinants of copper and molybdenum concentrations in serum at the end of the grazing season and associations with reproductive performance in beef cows from western Canada

2011 ◽  
Vol 91 (3) ◽  
pp. 423-431 ◽  
Author(s):  
Leanne Van De Weyer ◽  
Cheryl Waldner
Keyword(s):  
Reproductive Performance ◽  
Important Determinant ◽  
Beef Cows ◽  
Western Canada ◽  
Serum Concentrations ◽  
Soil Color ◽  
Grazing Season ◽  
Cu Deficiency ◽  
The Mean ◽  
Feed Samples

Van De Weyer, L. M. and Waldner, C. L. 2011. Geographic determinants of copper and molybdenum concentrations in serum at the end of the grazing season and associations with reproductive performance in beef cows from western Canada. Can. J. Anim. Sci. 91: 423–431. Serum concentrations of Cu and Mo were measured at the end of the summer grazing season in an observational field study of 783 breeding females from 66 cow-calf herds located in western Canada. The mean Cu concentration was 0.82 ppm (S, 0.30 ppm) and the mean Mo concentration was 0.056 ppm (S, 0.055 ppm). Serum Cu concentration differed across ecoregions (P=0.013). Serum Mo concentrations varied by ecoregion (P =0.002), soil type (P =0.011), soil color (P=0.018), and total precipitation during the growing season (P =0.004). Copper and Mo serum concentrations at the end of the grazing season were not associated with reproductive outcomes. Herd location is an important determinant of the risk of primary and secondary Cu deficiency and can inform the need for trace mineral testing of feed samples as well as supplementation.

Tissue and Serum Concentrations of Amoxycillin and Clavulanic Acid in Patients Having Reconstructive Vascular Surgery

1987 ◽  
Vol 15 (4) ◽  
pp. 205-211 ◽  
Author(s):  
J. J. Earnshaw ◽  
R. C. B. Slack ◽  
G. S. Makin ◽  
B. R. Hopkinson
Keyword(s):  
Vascular Surgery ◽  
Antibiotic Prophylaxis ◽  
Clavulanic Acid ◽  
Dose Schedule ◽  
Surgical Patients ◽  
Skin Closure ◽  
Serum Concentrations ◽  
Anaesthetic Induction ◽  
Tissue Concentrations ◽  
The Mean

Fifteen patients received amoxycillin/clavulanic acid combination intravenously at anaesthetic induction as part of a three-dose schedule of antibiotic prophylaxis for vascular surgery. After 30 min, the mean serum concentration of amoxycillin was 39.9 mg/l and clavulanic acid was 9.3 mg/1. Mean amoxycillin tissue concentrations in fat, 5.1 mg/l; vein, 7.5 mg/l; and artery, 4.8 mg/l, were lower than serum values. Mean clavulanic acid concentrations were: fat, 0.7 mg/l; vein, 1.2 mg/l; and artery, 1.6 mg/l. At the end of surgery, the serum amoxycillin level was always > 6 mg/l and clavulanic acid > 2 mg/l, which were both still within the therapeutic range. Concentrations in fat had declined by the end of the surgery ranging from 0.76 to 5.2 mg/l for amoxycillin and from 0.03 to 0.6 mg/l for clavulanic acid, there being almost none detected in four cases. Serum and tissue concentrations of both compounds 30 min after injection were sufficient to inhibit the growth of 97% of pathogenic organisms recovered from the skin of 135 vascular surgical patients. In a few cases tissue levels of the compounds were below inhibitory concentrations for conforms and anaerobes at the time of skin closure, although they were still effective against most Gram-positive organisms. Amoxycillin/clavulanic acid combination is suitable antibiotic prophylaxis for vascular surgery.

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